Details of the Target

General Information of Target

Target ID LDTP10625
Target Name Outer dynein arm-docking complex subunit 4 (ODAD4)
Gene Name ODAD4
Gene ID 83538
Synonyms
TTC25; Outer dynein arm-docking complex subunit 4; Tetratricopeptide repeat protein 25; TPR repeat protein 25
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNKLNFHNNRVMQDRRSVCIFLPNDESLNIIINVKILCHQLLVQVCDLLRLKDCHLFGLS
VIQNNEHVYMELSQKLYKYCPKEWKKEASKVRQYEVTWGIDQFGPPMIIHFRVQYYVENG
RLISDRAARYYYYWHLRKQVLHSQCVLREEAYFLLAAFALQADLGNFKRNKHYGKYFEPE
AYFPSWVVSKRGKDYILKHIPNMHKDQFALTASEAHLKYIKEAVRLDDVAVHYYRLYKDK
REIEASLTLGLTMRGIQIFQNLDEEKQLLYDFPWTNVGKLVFVGKKFEILPDGLPSARKL
IYYTGCPMRSRHLLQLLSNSHRLYMNLQPVLRHIRKLEENEEKKQYRESYISDNLDLDMD
QLEKRSRASGSSAGSMKHKRLSRHSTASHSSSHTSGIEADTKPRDTGPEDSYSSSAIHRK
LKTCSSMTSHGSSHTSGVESGGKDRLEEDLQDDEIEMLVDDPRDLEQMNEESLEVSPDMC
IYITEDMLMSRKLNGHSGLIVKEIGSSTSSSSETVVKLRGQSTDSLPQTICRKPKTSTDR
HSLSLDDIRLYQKDFLRIAGLCQDTAQSYTFGCGHELDEEGLYCNSCLAQQCINIQDAFP
VKRTSKYFSLDLTHDEVPEFVV
Target Bioclass
Other
Subcellular location
Cytoplasm, cytoskeleton, cilium axoneme
Function
Component of the outer dynein arm-docking complex (ODA-DC) that mediates outer dynein arms (ODA) binding onto the doublet microtubule. Plays an essential role for the assembly of ODA-DC and for the docking of ODA in ciliary axoneme.
Uniprot ID
Q96NG3
Ensemble ID
ENST00000377540.6
HGNC ID
HGNC:25280

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAMA1 SNV: p.G509E .
COLO792 SNV: p.G95E .
HCT116 SNV: p.G604D .
HCT15 SNV: p.Q445H .
IGR1 Substitution: p.G642N .
LNCaP clone FGC SNV: p.A603T .
MOLT4 SNV: p.L74I; p.P356L .
NCIH1155 SNV: p.S324N .
RL952 SNV: p.G420D .
SKES1 SNV: p.Q538H .
SNGM SNV: p.S76I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C26(2.05)  LDD3331  [1]
N1
 Probe Info  		N.A.  LDD0245  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C26(0.90)  LDD1507  [3]
 LDCM0215  AC10 HEK-293T C26(0.98)  LDD1508  [3]
 LDCM0276  AC17 HEK-293T C26(1.09)  LDD1515  [3]
 LDCM0277  AC18 HEK-293T C26(0.79)  LDD1516  [3]
 LDCM0279  AC2 HEK-293T C26(0.98)  LDD1518  [3]
 LDCM0281  AC21 HEK-293T C26(0.92)  LDD1520  [3]
 LDCM0285  AC25 HEK-293T C26(0.98)  LDD1524  [3]
 LDCM0286  AC26 HEK-293T C26(0.87)  LDD1525  [3]
 LDCM0289  AC29 HEK-293T C26(0.97)  LDD1528  [3]
 LDCM0294  AC33 HEK-293T C26(1.12)  LDD1533  [3]
 LDCM0295  AC34 HEK-293T C26(1.06)  LDD1534  [3]
 LDCM0298  AC37 HEK-293T C26(1.05)  LDD1537  [3]
 LDCM0303  AC41 HEK-293T C26(1.09)  LDD1542  [3]
 LDCM0304  AC42 HEK-293T C26(0.85)  LDD1543  [3]
 LDCM0307  AC45 HEK-293T C26(1.07)  LDD1546  [3]
 LDCM0311  AC49 HEK-293T C26(0.99)  LDD1550  [3]
 LDCM0312  AC5 HEK-293T C26(0.99)  LDD1551  [3]
 LDCM0313  AC50 HEK-293T C26(0.72)  LDD1552  [3]
 LDCM0316  AC53 HEK-293T C26(0.98)  LDD1555  [3]
 LDCM0320  AC57 HEK-293T C26(1.06)  LDD1559  [3]
 LDCM0321  AC58 HEK-293T C26(0.96)  LDD1560  [3]
 LDCM0325  AC61 HEK-293T C26(0.94)  LDD1564  [3]
 LDCM0248  AKOS034007472 HEK-293T C26(1.22)  LDD1511  [3]
 LDCM0356  AKOS034007680 HEK-293T C26(1.16)  LDD1570  [3]
 LDCM0369  CL100 HEK-293T C26(1.04)  LDD1573  [3]
 LDCM0373  CL104 HEK-293T C26(1.30)  LDD1577  [3]
 LDCM0377  CL108 HEK-293T C26(0.92)  LDD1581  [3]
 LDCM0382  CL112 HEK-293T C26(1.01)  LDD1586  [3]
 LDCM0386  CL116 HEK-293T C26(1.11)  LDD1590  [3]
 LDCM0391  CL120 HEK-293T C26(1.18)  LDD1595  [3]
 LDCM0395  CL124 HEK-293T C26(1.07)  LDD1599  [3]
 LDCM0399  CL128 HEK-293T C26(1.09)  LDD1603  [3]
 LDCM0403  CL16 HEK-293T C26(1.20)  LDD1607  [3]
 LDCM0404  CL17 HEK-293T C26(0.96)  LDD1608  [3]
 LDCM0405  CL18 HEK-293T C26(0.79)  LDD1609  [3]
 LDCM0409  CL21 HEK-293T C26(0.94)  LDD1613  [3]
 LDCM0416  CL28 HEK-293T C26(0.97)  LDD1620  [3]
 LDCM0417  CL29 HEK-293T C26(0.88)  LDD1621  [3]
 LDCM0419  CL30 HEK-293T C26(0.89)  LDD1623  [3]
 LDCM0422  CL33 HEK-293T C26(0.99)  LDD1626  [3]
 LDCM0429  CL4 HEK-293T C26(1.21)  LDD1633  [3]
 LDCM0430  CL40 HEK-293T C26(0.96)  LDD1634  [3]
 LDCM0431  CL41 HEK-293T C26(1.07)  LDD1635  [3]
 LDCM0432  CL42 HEK-293T C26(1.01)  LDD1636  [3]
 LDCM0435  CL45 HEK-293T C26(0.93)  LDD1639  [3]
 LDCM0440  CL5 HEK-293T C26(1.20)  LDD1644  [3]
 LDCM0443  CL52 HEK-293T C26(0.96)  LDD1646  [3]
 LDCM0444  CL53 HEK-293T C26(0.85)  LDD1647  [3]
 LDCM0445  CL54 HEK-293T C26(0.79)  LDD1648  [3]
 LDCM0448  CL57 HEK-293T C26(0.78)  LDD1651  [3]
 LDCM0451  CL6 HEK-293T C26(1.15)  LDD1654  [3]
 LDCM0456  CL64 HEK-293T C26(1.47)  LDD1659  [3]
 LDCM0457  CL65 HEK-293T C26(1.13)  LDD1660  [3]
 LDCM0458  CL66 HEK-293T C26(0.85)  LDD1661  [3]
 LDCM0461  CL69 HEK-293T C26(1.05)  LDD1664  [3]
 LDCM0469  CL76 HEK-293T C26(1.12)  LDD1672  [3]
 LDCM0470  CL77 HEK-293T C26(1.19)  LDD1673  [3]
 LDCM0471  CL78 HEK-293T C26(0.97)  LDD1674  [3]
 LDCM0475  CL81 HEK-293T C26(1.08)  LDD1678  [3]
 LDCM0482  CL88 HEK-293T C26(0.96)  LDD1685  [3]
 LDCM0483  CL89 HEK-293T C26(1.24)  LDD1686  [3]
 LDCM0484  CL9 HEK-293T C26(1.07)  LDD1687  [3]
 LDCM0485  CL90 HEK-293T C26(0.77)  LDD1688  [3]
 LDCM0488  CL93 HEK-293T C26(0.96)  LDD1691  [3]
 LDCM0022  KB02 A101D C26(1.73)  LDD2250  [1]
 LDCM0023  KB03 A101D C26(2.15)  LDD2667  [1]
 LDCM0024  KB05 MKN-1 C26(2.05)  LDD3331  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable E3 ubiquitin-protein ligase makorin-3 (MKRN3) . Q13064
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein MOX-2 (MEOX2) . P50222
Myogenin (MYOG) . P15173
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Coiled-coil domain-containing protein 85B (CCDC85B) CCDC85 family Q15834
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Centrosomal protein of 70 kDa (CEP70) . Q8NHQ1

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402