Details of the Target

General Information of Target

Target ID LDTP10581
Target Name KICSTOR subunit 2 (KICS2)
Gene Name KICS2
Gene ID 144577
Synonyms
C12orf66; KICSTOR subunit 2; KICSTOR complex protein C12orf66
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNPPGSLEALDPNVDEHLSTQILAPSVHSDNSQERIQARRLRIAARLEARRREALGEYLD
GKKESEEDQSKSYKQKEESRLKLAKLLLCGTELVTNIQVAIDIREIHRRVEEEEIKRQRI
EKLENEVKTSQDKFDEITSKWEEGKQKRIPQELWEMLNTQQLHCAGLLEDKNKLISELQQ
ELKTKDDQYVKDLKKQSDDICLLLERMEEQVKNVMKTFREELYNIEKAFEVERQELLASN
KKKWEQALQAHNAKELEYLNNRMKKVEDYEKQLNRQRIWDCEEYNMIKIKLEQDVQILEQ
QLQQRKAIYQLNQEKLEYNLQVLKKRDEESTVIKSQQKRKINRLHDILNNLRSKYAKQIK
QFQEENQSLTSDYKRLVMQFKELQKAMRHFALIDDEKFWEIWLMNEEEAKDLIARAFDVD
RIIHTHHLGLPWAAPDFWFLNNVGPISQQPQKSATQIVEEMLMRSEEEEAEEAAAEPESY
LDLPKQISEKTTKRILMLLCDESGFLIESKLLSLLLPLEQNECYLLRLDAIFSALGIESE
DDLYKLVNFFLKYRAHRLSSSLQIKPCSQASMEKASMEETSTRSELELAEQTEMEGEKEE
SLVEGEKEEEEETPPSPWVIHPNDVLKILEAFVMGLKKPRDSRAPLRVQKNVRDNSKDSE
YWQALTTVIPSSKQNLWDALYTALEKYHLVLTQRAKLLLENSSLEQQNTELQALLQQYLN
SKINSELQVPPTQVLRVPTK
Target Bioclass
Other
Family
KICS2 family
Subcellular location
Lysosome membrane
Function
As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.
Uniprot ID
Q96MD2
Ensemble ID
ENST00000398055.8
HGNC ID
HGNC:26517

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C130(0.97)  LDD1508  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C130(0.97)  LDD1508  [1]
 LDCM0226  AC11 HEK-293T C195(0.86)  LDD1509  [1]
 LDCM0277  AC18 HEK-293T C130(0.93)  LDD1516  [1]
 LDCM0278  AC19 HEK-293T C195(0.69)  LDD1517  [1]
 LDCM0279  AC2 HEK-293T C130(0.83)  LDD1518  [1]
 LDCM0286  AC26 HEK-293T C130(0.97)  LDD1525  [1]
 LDCM0287  AC27 HEK-293T C195(0.91)  LDD1526  [1]
 LDCM0290  AC3 HEK-293T C195(1.16)  LDD1529  [1]
 LDCM0295  AC34 HEK-293T C130(0.83)  LDD1534  [1]
 LDCM0296  AC35 HEK-293T C195(0.92)  LDD1535  [1]
 LDCM0304  AC42 HEK-293T C130(0.98)  LDD1543  [1]
 LDCM0305  AC43 HEK-293T C195(0.89)  LDD1544  [1]
 LDCM0313  AC50 HEK-293T C130(0.98)  LDD1552  [1]
 LDCM0314  AC51 HEK-293T C195(0.95)  LDD1553  [1]
 LDCM0321  AC58 HEK-293T C130(0.93)  LDD1560  [1]
 LDCM0322  AC59 HEK-293T C195(0.89)  LDD1561  [1]
 LDCM0369  CL100 HEK-293T C130(1.00)  LDD1573  [1]
 LDCM0371  CL102 HEK-293T C195(1.18)  LDD1575  [1]
 LDCM0373  CL104 HEK-293T C130(0.87)  LDD1577  [1]
 LDCM0375  CL106 HEK-293T C195(0.99)  LDD1579  [1]
 LDCM0377  CL108 HEK-293T C130(1.29)  LDD1581  [1]
 LDCM0380  CL110 HEK-293T C195(0.94)  LDD1584  [1]
 LDCM0382  CL112 HEK-293T C130(1.08)  LDD1586  [1]
 LDCM0384  CL114 HEK-293T C195(1.09)  LDD1588  [1]
 LDCM0386  CL116 HEK-293T C130(1.11)  LDD1590  [1]
 LDCM0388  CL118 HEK-293T C195(0.96)  LDD1592  [1]
 LDCM0391  CL120 HEK-293T C130(1.43)  LDD1595  [1]
 LDCM0393  CL122 HEK-293T C195(1.20)  LDD1597  [1]
 LDCM0395  CL124 HEK-293T C130(0.82)  LDD1599  [1]
 LDCM0397  CL126 HEK-293T C195(1.03)  LDD1601  [1]
 LDCM0399  CL128 HEK-293T C130(1.11)  LDD1603  [1]
 LDCM0401  CL14 HEK-293T C195(1.02)  LDD1605  [1]
 LDCM0403  CL16 HEK-293T C130(1.00)  LDD1607  [1]
 LDCM0405  CL18 HEK-293T C130(0.91)  LDD1609  [1]
 LDCM0406  CL19 HEK-293T C195(0.93)  LDD1610  [1]
 LDCM0407  CL2 HEK-293T C195(1.07)  LDD1611  [1]
 LDCM0414  CL26 HEK-293T C195(1.18)  LDD1618  [1]
 LDCM0416  CL28 HEK-293T C130(1.19)  LDD1620  [1]
 LDCM0419  CL30 HEK-293T C130(0.92)  LDD1623  [1]
 LDCM0420  CL31 HEK-293T C195(0.87)  LDD1624  [1]
 LDCM0429  CL4 HEK-293T C130(0.96)  LDD1633  [1]
 LDCM0430  CL40 HEK-293T C130(1.01)  LDD1634  [1]
 LDCM0432  CL42 HEK-293T C130(0.86)  LDD1636  [1]
 LDCM0433  CL43 HEK-293T C195(0.88)  LDD1637  [1]
 LDCM0441  CL50 HEK-293T C195(1.14)  LDD1645  [1]
 LDCM0443  CL52 HEK-293T C130(1.30)  LDD1646  [1]
 LDCM0445  CL54 HEK-293T C130(0.83)  LDD1648  [1]
 LDCM0446  CL55 HEK-293T C195(0.90)  LDD1649  [1]
 LDCM0451  CL6 HEK-293T C130(0.87)  LDD1654  [1]
 LDCM0454  CL62 HEK-293T C195(1.28)  LDD1657  [1]
 LDCM0456  CL64 HEK-293T C130(1.03)  LDD1659  [1]
 LDCM0458  CL66 HEK-293T C130(1.16)  LDD1661  [1]
 LDCM0459  CL67 HEK-293T C195(0.92)  LDD1662  [1]
 LDCM0462  CL7 HEK-293T C195(0.88)  LDD1665  [1]
 LDCM0467  CL74 HEK-293T C195(1.04)  LDD1670  [1]
 LDCM0469  CL76 HEK-293T C130(1.23)  LDD1672  [1]
 LDCM0471  CL78 HEK-293T C130(1.01)  LDD1674  [1]
 LDCM0472  CL79 HEK-293T C195(0.96)  LDD1675  [1]
 LDCM0480  CL86 HEK-293T C195(1.08)  LDD1683  [1]
 LDCM0482  CL88 HEK-293T C130(1.05)  LDD1685  [1]
 LDCM0485  CL90 HEK-293T C130(0.77)  LDD1688  [1]
 LDCM0486  CL91 HEK-293T C195(0.84)  LDD1689  [1]
 LDCM0493  CL98 HEK-293T C195(1.11)  LDD1696  [1]
 LDCM0427  Fragment51 HEK-293T C195(1.22)  LDD1631  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402