General Information of Target

Target ID LDTP10544
Target Name Sialic acid-binding Ig-like lectin 10 (SIGLEC10)
Gene Name SIGLEC10
Gene ID 89790
Synonyms
SLG2; Sialic acid-binding Ig-like lectin 10; Siglec-10; Siglec-like protein 2
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MGTLPWLLAFFILGLQAWDTPTIVSRKEWGARPLACRALLTLPVAYIITDQLPGMQCQQQ
SVCSQMLRGLQSHSVYTIGWCDVAYNFLVGDDGRVYEGVGWNIQGLHTQGYNNISLGIAF
FGNKIGSSPSPAALSAAEGLISYAIQKGHLSPRYIQPLLLKEETCLDPQHPVMPRKVCPN
IIKRSAWEARETHCPKMNLPAKYVIIIHTAGTSCTVSTDCQTVVRNIQSFHMDTRNFCDI
GYHFLVGQDGGVYEGVGWHIQGSHTYGFNDIALGIAFIGYFVEKPPNAAALEAAQDLIQC
AVVEGYLTPNYLLMGHSDVVNILSPGQALYNIISTWPHFKH
Target Bioclass
Immunoglobulin
Family
Immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family
Subcellular location
Secreted; Cell membrane
Function
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, seems to act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Involved in negative regulation of B-cell antigen receptor signaling. The inhibition of B cell activation is dependent on PTPN6/SHP-1. In association with CD24 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. In association with CD24 may regulate the immune repsonse of natural killer (NK) cells. Plays a role in the control of autoimmunity. During initiation of adaptive immune responses by CD8-alpha(+) dendritic cells inhibits cross-presentation by impairing the formation of MHC class I-peptide complexes. The function seems to implicate recruitment of PTPN6/SHP-1, which dephosphorylates NCF1 of the NADPH oxidase complex consequently promoting phagosomal acidification.
Uniprot ID
Q96LC7
Ensemble ID
ENST00000339313.10
HGNC ID
HGNC:15620
ChEMBL ID
CHEMBL4303061

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HT115 SNV: p.F61C .
HUPT4 Deletion: p.V139Ter .
J82 SNV: p.S488N .
KATOIII SNV: p.P282T .
KMCH1 SNV: p.R414G .
LN229 Substitution: p.P311R .
LS180 SNV: p.R320C .
MELHO Substitution: p.Q281P .
NCIH1155 SNV: p.G157E .
REH SNV: p.T65A .
RT112 Substitution: p.P311R .
SNGM SNV: p.A184V .
SW403 SNV: p.G500W .
ZR751 Substitution: p.P311R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info 
C101(0.44)  LDD2182  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0625  F8 Ramos C101(0.49)  LDD2187  [1]
 LDCM0572  Fragment10 Ramos C101(0.55)  LDD2189  [1]
 LDCM0573  Fragment11 Ramos C101(1.57)  LDD2190  [1]
 LDCM0574  Fragment12 Ramos C101(0.67)  LDD2191  [1]
 LDCM0575  Fragment13 Ramos C101(0.99)  LDD2192  [1]
 LDCM0576  Fragment14 Ramos C101(1.43)  LDD2193  [1]
 LDCM0579  Fragment20 Ramos C101(0.58)  LDD2194  [1]
 LDCM0580  Fragment21 Ramos C101(0.88)  LDD2195  [1]
 LDCM0582  Fragment23 Ramos C101(0.44)  LDD2196  [1]
 LDCM0578  Fragment27 Ramos C101(0.82)  LDD2197  [1]
 LDCM0586  Fragment28 Ramos C101(0.32)  LDD2198  [1]
 LDCM0588  Fragment30 Ramos C101(1.10)  LDD2199  [1]
 LDCM0589  Fragment31 Ramos C101(1.13)  LDD2200  [1]
 LDCM0590  Fragment32 Ramos C101(0.42)  LDD2201  [1]
 LDCM0468  Fragment33 Ramos C101(0.78)  LDD2202  [1]
 LDCM0596  Fragment38 Ramos C101(1.03)  LDD2203  [1]
 LDCM0566  Fragment4 Ramos C101(0.86)  LDD2184  [1]
 LDCM0610  Fragment52 Ramos C101(1.48)  LDD2204  [1]
 LDCM0614  Fragment56 Ramos C101(2.44)  LDD2205  [1]
 LDCM0569  Fragment7 Ramos C101(0.63)  LDD2186  [1]
 LDCM0571  Fragment9 Ramos C101(0.54)  LDD2188  [1]
 LDCM0022  KB02 Ramos C101(0.44)  LDD2182  [1]
 LDCM0023  KB03 Ramos C101(0.74)  LDD2183  [1]
 LDCM0024  KB05 Ramos C101(0.52)  LDD2185  [1]

References

1 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578