Details of the Target

General Information of Target

Target ID LDTP10518
Target Name Leishmanolysin-like peptidase (LMLN)
Gene Name LMLN
Gene ID 89782
Synonyms
Leishmanolysin-like peptidase; EC 3.4.24.-; Invadolysin
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLGDTPRSEETLPKATPDSLE
PAGPSSPASVTVTVGDEGADTPVGATPLIGDESENLEGDGDLRGGRILLGHATKSFPSSP
SKGGSCPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAAAAGSEPPPATTSPEGQPKV
HRARKTMSKPGNGQPPVPEKRPPEIQHFRMSDDVHSLGKVTSDLAKRRKLNSGGGLSEEL
GSARRSGEVTLTKGDPGSLEEWETVVGDDFSLYYDSYSVDERVDSDSKSEVEALTEQLSE
EEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKAKKKWRKDSPWVKPSRKRR
KREPPRAKEPRGVNGVGSSGPSEYMEVPLGSLELPSEGTLSPNHAGVSNDTSSLETERGF
EELPLCSCRMEAPKIDRISERAGHKCMATESVDGELSGCNAAILKRETMRPSSRVALMVL
CETHRARMVKHHCCPGCGYFCTAGTFLECHPDFRVAHRFHKACVSQLNGMVFCPHCGEDA
SEAQEVTIPRGDGVTPPAGTAAPAPPPLSQDVPGRADTSQPSARMRGHGEPRRPPCDPLA
DTIDSSGPSLTLPNGGCLSAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQ
GELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRT
PLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNA
QDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNA
RCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFA
LQLNRKLRLGVGNRAIRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETS
TMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQA
CSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVR
EDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFS
SRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSRLARLDPHPELLP
ELGSLPPVNT
Target Bioclass
Enzyme
Family
Peptidase M8 family
Subcellular location
Cytoplasm
Function Metalloprotease.
Uniprot ID
Q96KR4
Ensemble ID
ENST00000330198.8
HGNC ID
HGNC:15991

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C441(1.06)  LDD1507  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C441(1.06)  LDD1507  [1]
 LDCM0259  AC14 HEK-293T C441(1.16)  LDD1512  [1]
 LDCM0276  AC17 HEK-293T C441(1.07)  LDD1515  [1]
 LDCM0282  AC22 HEK-293T C441(0.95)  LDD1521  [1]
 LDCM0285  AC25 HEK-293T C441(1.07)  LDD1524  [1]
 LDCM0291  AC30 HEK-293T C441(1.01)  LDD1530  [1]
 LDCM0294  AC33 HEK-293T C441(1.18)  LDD1533  [1]
 LDCM0299  AC38 HEK-293T C441(1.03)  LDD1538  [1]
 LDCM0303  AC41 HEK-293T C441(1.00)  LDD1542  [1]
 LDCM0308  AC46 HEK-293T C441(0.99)  LDD1547  [1]
 LDCM0311  AC49 HEK-293T C441(1.09)  LDD1550  [1]
 LDCM0317  AC54 HEK-293T C441(1.18)  LDD1556  [1]
 LDCM0320  AC57 HEK-293T C441(1.26)  LDD1559  [1]
 LDCM0323  AC6 HEK-293T C441(0.91)  LDD1562  [1]
 LDCM0326  AC62 HEK-293T C441(1.18)  LDD1565  [1]
 LDCM0356  AKOS034007680 HEK-293T C441(1.03)  LDD1570  [1]
 LDCM0368  CL10 HEK-293T C441(1.22)  LDD1572  [1]
 LDCM0404  CL17 HEK-293T C441(1.37)  LDD1608  [1]
 LDCM0410  CL22 HEK-293T C441(1.29)  LDD1614  [1]
 LDCM0417  CL29 HEK-293T C441(0.98)  LDD1621  [1]
 LDCM0423  CL34 HEK-293T C441(1.16)  LDD1627  [1]
 LDCM0431  CL41 HEK-293T C441(1.15)  LDD1635  [1]
 LDCM0436  CL46 HEK-293T C441(1.08)  LDD1640  [1]
 LDCM0440  CL5 HEK-293T C441(1.23)  LDD1644  [1]
 LDCM0444  CL53 HEK-293T C441(1.29)  LDD1647  [1]
 LDCM0449  CL58 HEK-293T C441(1.18)  LDD1652  [1]
 LDCM0457  CL65 HEK-293T C441(1.03)  LDD1660  [1]
 LDCM0463  CL70 HEK-293T C441(1.28)  LDD1666  [1]
 LDCM0470  CL77 HEK-293T C441(1.27)  LDD1673  [1]
 LDCM0476  CL82 HEK-293T C441(1.05)  LDD1679  [1]
 LDCM0483  CL89 HEK-293T C441(1.06)  LDD1686  [1]
 LDCM0489  CL94 HEK-293T C441(1.10)  LDD1692  [1]
 LDCM0022  KB02 A2058 C478(1.80)  LDD2253  [2]
 LDCM0023  KB03 A2058 C478(3.50)  LDD2670  [2]
 LDCM0024  KB05 COLO-679 C478(3.80)  LDD3139  [2]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840