Details of the Target

General Information of Target

Target ID LDTP10506
Target Name Histone H2A type 1-H (H2AC12)
Gene Name H2AC12
Gene ID 85235
Synonyms
HIST1H2AH; HIST1H2AI; Histone H2A type 1-H; H2A-clustered histone 12; Histone H2A/s
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSANTSMVTEFLLLGFSHLADLQGLLFSVFLTIYLLTVAGNFLIVVLVSTDAALQSPMYF
FLRTLSALEIGYTSVTVPLLLHHLLTGRRHISRSGCALQMFFFLFFGATECCLLAAMAYD
RYAAICEPLRYPLLLSHRVCLQLAGSAWACGVLVGLGHTPFIFSLPFCGPNTIPQFFCEI
QPVLQLVCGDTSLNELQIILATALLILCPFGLILGSYGRILVTIFRIPSVAGRRKAFSTC
SSHLIMVSLFYGTALFIYIRPKASYDPATDPLVSLFYAVVTPILNPIIYSLRNTEVKAAL
KRTIQKTVPMEI
Target Bioclass
Other
Family
Histone H2A family
Subcellular location
Nucleus
Function
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Uniprot ID
Q96KK5
Ensemble ID
ENST00000377459.3
HGNC ID
HGNC:13671

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AZ-9
 Probe Info  		E92(1.09)  LDD2208  [1]
TER-AC
 Probe Info  		N.A.  LDD0426  [2]
TPP-AC
 Probe Info  		N.A.  LDD0427  [2]

References

1 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
2 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.