Details of the Target

General Information of Target

Target ID LDTP10483
Target Name Protocadherin-16 (DCHS1)
Gene Name DCHS1
Gene ID 8642
Synonyms
CDH19; CDH25; FIB1; KIAA1773; PCDH16; Protocadherin-16; Cadherin-19; Cadherin-25; Fibroblast cadherin-1; Protein dachsous homolog 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRRCRWAALALGLLRLCLAQANFAPHFFDNGVGSTNGNMALFSLPEDTPVGSHVYTLNGT
DPEGDPISYHISFDPSTRSVFSVDPTFGNITLVEELDREREDEIEAIISISDGLNLVAEK
VVILVTDANDEAPRFIQEPYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLHSP
FAVDRHSGVLRLQAGATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQ
DMAPVFVGTPYYGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGNDGAFEINETSG
AISITQSPAQLQREVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQ
NRFELSMNEHPPQGEILRGLKITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVT
IIVENSAAIDFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVAR
IPENAPGGSSVVAVTAVDPDTGPWGEVKYSTYGTGADLFLIHPSTGLIYTQPWASLDAEA
TARYNFYVKAEDMEGKYSVAEVFITLLDVNDHPPQFGKSVQKKTMVLGTPVKIEAIDEDA
EEPNNLVDYSITHAEPANVFDINSHTGEIWLKNSIRSLDALHNITPGRDCLWSLEVQAKD
RGSPSFSTTALLKIDITDAETLSRSPMAAFLIQTKDNPMKAVGVLAGTMATVVAITVLIS
TATFWRNKKSNKVLPMRRVLRKRPSPAPRTIRIEWLKSKSTKAATKFMLKEKPPNENCNN
NSPESSLLPRAPALPPPPSVAPSTGAAQWTVPTVSGSLTPQPTQPPPKPKTMGSPVQSTL
ISELKQKFEKKSVHNKAYF
Target Bioclass
Other
Subcellular location
Cell membrane
Function
Calcium-dependent cell-adhesion protein. Mediates functions in neuroprogenitor cell proliferation and differentiation. In the heart, has a critical role for proper morphogenesis of the mitral valve, acting in the regulation of cell migration involved in valve formation.
Uniprot ID
Q96JQ0
Ensemble ID
ENST00000299441.5
HGNC ID
HGNC:13681

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C639(1.83)  LDD3340  [1]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-2
 Probe Info  		N.A.  LDD0138  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0259  AC14 HEK-293T C2667(0.88)  LDD1512  [3]
 LDCM0282  AC22 HEK-293T C2667(1.03)  LDD1521  [3]
 LDCM0291  AC30 HEK-293T C2667(0.97)  LDD1530  [3]
 LDCM0299  AC38 HEK-293T C2667(0.93)  LDD1538  [3]
 LDCM0308  AC46 HEK-293T C2667(0.98)  LDD1547  [3]
 LDCM0317  AC54 HEK-293T C2667(1.05)  LDD1556  [3]
 LDCM0323  AC6 HEK-293T C2667(0.94)  LDD1562  [3]
 LDCM0326  AC62 HEK-293T C2667(0.93)  LDD1565  [3]
 LDCM0368  CL10 HEK-293T C2667(1.02)  LDD1572  [3]
 LDCM0410  CL22 HEK-293T C2667(0.92)  LDD1614  [3]
 LDCM0423  CL34 HEK-293T C2667(0.89)  LDD1627  [3]
 LDCM0436  CL46 HEK-293T C2667(0.88)  LDD1640  [3]
 LDCM0449  CL58 HEK-293T C2667(0.88)  LDD1652  [3]
 LDCM0463  CL70 HEK-293T C2667(0.85)  LDD1666  [3]
 LDCM0476  CL82 HEK-293T C2667(0.93)  LDD1679  [3]
 LDCM0489  CL94 HEK-293T C2667(0.85)  LDD1692  [3]
 LDCM0022  KB02 A673 C3193(1.49)  LDD2261  [1]
 LDCM0023  KB03 42-MG-BA C3193(1.87)  LDD2661  [1]
 LDCM0024  KB05 NB1 C639(1.83)  LDD3340  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402