Details of the Target

General Information of Target

Target ID LDTP10427
Target Name Zinc finger BED domain-containing protein 3 (ZBED3)
Gene Name ZBED3
Gene ID 84327
Synonyms
Zinc finger BED domain-containing protein 3; Axin-interacting protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPTALCPRVLAPKESEEPRKMRSPPGENPSPQGELPSPESSRRLFRRFRYQEAAGPREAL
QRLWDLCGGWLRPERHTKEQILELLVLEQFLAILPREIQSWVRAQEPESGEQAVAAVEAL
EREPGRPWQWLKHCEDPVVIDDGDSPLDQEQEQLPVEPHSDLAKNQDAQPITLAQCLGLP
SRPPSQLSGDPVLQDAFLLQEENVRDTQQVTTLQLPPSRVSPFKDMILCFSEEDWSLLDP
AQTGFYGEFIIGEDYGVSMPPNDLAAQPDLSQGEENEPRVPELQDLQGKEVPQVSYLDSP
SLQPFQVEERRKREELQVPEFQACPQTVVPQNTYPAGGNPRSLENSLDEEVTIEIVLSSS
GDEDSQHGPYCTEELGSPTEKQRSLPASHRSSTEAGGEVQTSKKSYVCPNCGKIFRWRVN
FIRHLRSRREQEKPHECSVCGELFSDSEDLDGHLESHEAQKPYRCGACGKSFRLNSHLLS
HRRIHLQPDRLQPVEKREQAASEDADKGPKEPLENGKAKLSFQCCECGKAFQRHDHLARH
RSHFHLKDKARPFQCRYCVKSFTQNYDLLRHERLHMKRRSKQALNSY
Target Bioclass
Transcription factor
Subcellular location
Cytoplasm
Function
Acts as a positive regulator in the activation of the canonical Wnt/beta-catenin signaling pathway by stabilizing cytoplasmic beta-catenin. Involved in transcription activation of Wnt target gene expression. Plays a role in symmetric division of blastomeres in the early stages of embryogenesis via regulation of mitotic spindle central positioning and organization of the F-actin filament network. Plays a role in regulating the distribution of cellular organelles, via modulation of cytoskeletal dynamics and cytoplasmic lattice formation.
Uniprot ID
Q96IU2
Ensemble ID
ENST00000255198.3
HGNC ID
HGNC:20711

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C227(0.94)  LDD1492  [1]
IPM
 Probe Info  		N.A.  LDD0025  [2]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [2]
TFBX
 Probe Info  		N.A.  LDD0027  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C26(1.39)  LDD1508  [1]
 LDCM0237  AC12 HEK-293T C26(1.25)  LDD1510  [1]
 LDCM0277  AC18 HEK-293T C26(1.06)  LDD1516  [1]
 LDCM0279  AC2 HEK-293T C26(0.99)  LDD1518  [1]
 LDCM0280  AC20 HEK-293T C26(0.87)  LDD1519  [1]
 LDCM0286  AC26 HEK-293T C26(0.92)  LDD1525  [1]
 LDCM0288  AC28 HEK-293T C26(1.41)  LDD1527  [1]
 LDCM0295  AC34 HEK-293T C26(1.01)  LDD1534  [1]
 LDCM0297  AC36 HEK-293T C26(1.09)  LDD1536  [1]
 LDCM0301  AC4 HEK-293T C26(1.17)  LDD1540  [1]
 LDCM0304  AC42 HEK-293T C26(0.99)  LDD1543  [1]
 LDCM0306  AC44 HEK-293T C26(1.50)  LDD1545  [1]
 LDCM0313  AC50 HEK-293T C26(0.95)  LDD1552  [1]
 LDCM0315  AC52 HEK-293T C26(1.19)  LDD1554  [1]
 LDCM0321  AC58 HEK-293T C26(1.17)  LDD1560  [1]
 LDCM0324  AC60 HEK-293T C26(0.89)  LDD1563  [1]
 LDCM0405  CL18 HEK-293T C26(1.27)  LDD1609  [1]
 LDCM0408  CL20 HEK-293T C26(0.93)  LDD1612  [1]
 LDCM0419  CL30 HEK-293T C26(0.75)  LDD1623  [1]
 LDCM0421  CL32 HEK-293T C26(0.90)  LDD1625  [1]
 LDCM0432  CL42 HEK-293T C26(0.93)  LDD1636  [1]
 LDCM0434  CL44 HEK-293T C26(1.28)  LDD1638  [1]
 LDCM0445  CL54 HEK-293T C26(0.63)  LDD1648  [1]
 LDCM0447  CL56 HEK-293T C26(0.71)  LDD1650  [1]
 LDCM0451  CL6 HEK-293T C26(1.14)  LDD1654  [1]
 LDCM0458  CL66 HEK-293T C26(0.92)  LDD1661  [1]
 LDCM0460  CL68 HEK-293T C26(1.34)  LDD1663  [1]
 LDCM0471  CL78 HEK-293T C26(1.31)  LDD1674  [1]
 LDCM0473  CL8 HEK-293T C26(1.14)  LDD1676  [1]
 LDCM0474  CL80 HEK-293T C26(1.13)  LDD1677  [1]
 LDCM0485  CL90 HEK-293T C26(0.82)  LDD1688  [1]
 LDCM0487  CL92 HEK-293T C26(0.93)  LDD1690  [1]
 LDCM0022  KB02 HEK-293T C227(0.94)  LDD1492  [1]
 LDCM0023  KB03 HEK-293T C227(1.01)  LDD1497  [1]
 LDCM0024  KB05 HEK-293T C227(0.87)  LDD1502  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255