Details of the Target

General Information of Target

Target ID LDTP10421
Target Name Cytochrome c oxidase assembly factor 8 (COA8)
Gene Name COA8
Gene ID 84334
Synonyms
APOP1; APOPT1; C14orf153; Cytochrome c oxidase assembly factor 8; COA8; Apoptogenic protein 1, mitochondrial; APOP-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGSLSSRVLRQPRPALAQQAQGARAGGSARRPDTGDDAAGHGFCYCAGSHKRKRSSGSFC
YCHPDSETDEDEEEGDEQQRLLNTPRRKKLKSTSKYIYQTLFLNGENSDIKICALGEEWS
LHKIYLCQSGYFSSMFSGSWKESSMNIIELEIPDQNIDVEALQVAFGSLYRDDVLIKPSR
VVAILAAACLLQLDGLIQQCGETMKETVNVKTVCGYYTSAGTYGLDSVKKKCLEWLLNNL
MTHQNVELFKELSINVMKQLIGSSNLFVMQVEMDIYTALKKWMFLQLVPSWNGSLKQLLT
ETDVWFSKQRKDFEGMAFLETEQGKPFVSVFRHLRLQYIISDLASARIIEQDAVVPSEWL
SSVYKQQWFAMLRAEQDSEVGPQEINKEELEGNSMRCGRKLAKDGEYCWRWTGFNFGFDL
LVTYTNRYIIFKRNTLNQPCSGSVSLQPRRSIAFRLRLASFDSSGKLICSRTTGYQILTL
EKDQEQVVMNLDSRLLIFPLYICCNFLYISPEKKN
Target Bioclass
Other
Family
COA8 family
Subcellular location
Mitochondrion inner membrane
Function Required for cytochrome c complex (COX) IV assembly and function Protects COX assembly from oxidation-induced degradation, COX being the terminal component of the mitochondrial respiratory chain.
Uniprot ID
Q96IL0
Ensemble ID
ENST00000674165.1
HGNC ID
HGNC:20492

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		C4(0.78)  LDD1702  [1]
DBIA
 Probe Info  		C65(1.07)  LDD1510  [2]
1d-yne
 Probe Info  		N.A.  LDD0356  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0237  AC12 HEK-293T C65(1.07)  LDD1510  [2]
 LDCM0280  AC20 HEK-293T C65(0.98)  LDD1519  [2]
 LDCM0288  AC28 HEK-293T C65(1.03)  LDD1527  [2]
 LDCM0297  AC36 HEK-293T C65(1.10)  LDD1536  [2]
 LDCM0301  AC4 HEK-293T C65(0.97)  LDD1540  [2]
 LDCM0306  AC44 HEK-293T C65(1.51)  LDD1545  [2]
 LDCM0315  AC52 HEK-293T C65(1.20)  LDD1554  [2]
 LDCM0324  AC60 HEK-293T C65(0.89)  LDD1563  [2]
 LDCM0367  CL1 HEK-293T C65(1.00)  LDD1571  [2]
 LDCM0370  CL101 HEK-293T C65(0.96)  LDD1574  [2]
 LDCM0374  CL105 HEK-293T C65(1.17)  LDD1578  [2]
 LDCM0378  CL109 HEK-293T C65(1.03)  LDD1582  [2]
 LDCM0383  CL113 HEK-293T C65(1.02)  LDD1587  [2]
 LDCM0387  CL117 HEK-293T C65(1.10)  LDD1591  [2]
 LDCM0392  CL121 HEK-293T C65(1.10)  LDD1596  [2]
 LDCM0396  CL125 HEK-293T C65(1.02)  LDD1600  [2]
 LDCM0400  CL13 HEK-293T C65(1.19)  LDD1604  [2]
 LDCM0408  CL20 HEK-293T C65(0.87)  LDD1612  [2]
 LDCM0413  CL25 HEK-293T C65(0.96)  LDD1617  [2]
 LDCM0421  CL32 HEK-293T C65(1.07)  LDD1625  [2]
 LDCM0426  CL37 HEK-293T C65(0.98)  LDD1630  [2]
 LDCM0434  CL44 HEK-293T C65(1.28)  LDD1638  [2]
 LDCM0439  CL49 HEK-293T C65(1.01)  LDD1643  [2]
 LDCM0447  CL56 HEK-293T C65(1.19)  LDD1650  [2]
 LDCM0453  CL61 HEK-293T C65(0.98)  LDD1656  [2]
 LDCM0460  CL68 HEK-293T C65(1.04)  LDD1663  [2]
 LDCM0466  CL73 HEK-293T C65(1.20)  LDD1669  [2]
 LDCM0473  CL8 HEK-293T C65(0.93)  LDD1676  [2]
 LDCM0474  CL80 HEK-293T C65(1.25)  LDD1677  [2]
 LDCM0479  CL85 HEK-293T C65(0.89)  LDD1682  [2]
 LDCM0487  CL92 HEK-293T C65(1.09)  LDD1690  [2]
 LDCM0492  CL97 HEK-293T C65(1.05)  LDD1695  [2]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C4(0.78)  LDD1702  [1]

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
3 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.