Details of the Target

General Information of Target

Target ID LDTP10366
Target Name Tectonic-2 (TCTN2)
Gene Name TCTN2
Gene ID 79867
Synonyms
C12orf38; TECT2; Tectonic-2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLRTSVLRLLGRTGASRLSLLEDFGPRYYSSGSLSAGDDACDVRAYFTTPIFYVNAAPHI
GHLYSALLADALCRHRRLRGPSTAATRFSTGTDEHGLKIQQAAATAGLAPTELCDRVSEQ
FQQLFQEAGISCTDFIRTTEARHRVAVQHFWGVLKSRGLLYKGVYEGWYCASDECFLPEA
KVTQQPGPSGDSFPVSLESGHPVSWTKEENYIFRLSQFRKPLQRWLRGNPQAITPEPFHH
VVLQWLDEELPDLSVSRRSSHLHWGIPVPGDDSQTIYVWLDALVNYLTVIGYPNAEFKSW
WPATSHIIGKDILKFHAIYWPAFLLGAGMSPPQRICVHSHWTVCGQKMSKSLGNVVDPRT
CLNRYTVDGFRYFLLRQGVPNWDCDYYDEKVVKLLNSELADALGGLLNRCTAKRINPSET
YPAFCTTCFPSEPGLVGPSVRAQAEDYALVSAVATLPKQVADHYDNFRIYKALEAVSSCV
RQTNGFVQRHAPWKLNWESPVDAPWLGTVLHVALECLRVFGTLLQPVTPSLADKLLSRLG
VSASERSLGELYFLPRFYGHPCPFEGRRLGPETGLLFPRLDQSRTWLVKAHRT
Target Bioclass
Other
Family
Tectonic family
Subcellular location
Membrane
Function
Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for hedgehog signaling transduction.
Uniprot ID
Q96GX1
Ensemble ID
ENST00000303372.7
HGNC ID
HGNC:25774

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DU145 SNV: p.V141L .
EFO21 SNV: p.D641G .
HCT15 SNV: p.T122I .
HEC1 SNV: p.P39H .
HEC1B SNV: p.P39H .
HT115 SNV: p.I386V; p.R508I .
HUH7 SNV: p.V298M .
IGR37 SNV: p.V379G .
IGR39 SNV: p.V379G .
JURKAT SNV: p.R12K .
KELLY SNV: p.D260A .
MV411 SNV: p.D331N .
NCIH82 SNV: p.T322P .
RKN SNV: p.L247F .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C202(1.65); C219(1.65)  LDD1093  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C202(1.65); C219(1.65)  LDD1093  [1]
 LDCM0276  AC17 PaTu 8988t C202(1.09); C219(1.09)  LDD1155  [1]
 LDCM0277  AC18 PaTu 8988t C202(1.08); C219(1.08)  LDD1156  [1]
 LDCM0278  AC19 PaTu 8988t C202(1.12); C219(1.12)  LDD1157  [1]
 LDCM0279  AC2 PaTu 8988t C202(1.12); C219(1.12)  LDD1158  [1]
 LDCM0280  AC20 PaTu 8988t C202(1.19); C219(1.19)  LDD1159  [1]
 LDCM0281  AC21 PaTu 8988t C202(0.87); C219(0.87)  LDD1160  [1]
 LDCM0282  AC22 PaTu 8988t C202(1.26); C219(1.26)  LDD1161  [1]
 LDCM0283  AC23 PaTu 8988t C202(1.31); C219(1.31)  LDD1162  [1]
 LDCM0284  AC24 PaTu 8988t C202(1.31); C219(1.31)  LDD1163  [1]
 LDCM0290  AC3 PaTu 8988t C202(1.12); C219(1.12)  LDD1169  [1]
 LDCM0301  AC4 PaTu 8988t C202(0.88); C219(0.88)  LDD1180  [1]
 LDCM0308  AC46 PaTu 8988t C202(1.43); C219(1.43)  LDD1187  [1]
 LDCM0309  AC47 PaTu 8988t C202(1.43); C219(1.43)  LDD1188  [1]
 LDCM0310  AC48 PaTu 8988t C202(1.46); C219(1.46)  LDD1189  [1]
 LDCM0311  AC49 PaTu 8988t C202(1.65); C219(1.65)  LDD1190  [1]
 LDCM0312  AC5 PaTu 8988t C202(1.33); C219(1.33)  LDD1191  [1]
 LDCM0313  AC50 PaTu 8988t C202(1.73); C219(1.73)  LDD1192  [1]
 LDCM0314  AC51 PaTu 8988t C202(0.76); C219(0.76)  LDD1193  [1]
 LDCM0315  AC52 PaTu 8988t C202(1.16); C219(1.16)  LDD1194  [1]
 LDCM0316  AC53 PaTu 8988t C202(1.80); C219(1.80)  LDD1195  [1]
 LDCM0317  AC54 PaTu 8988t C202(2.22); C219(2.22)  LDD1196  [1]
 LDCM0318  AC55 PaTu 8988t C202(1.32); C219(1.32)  LDD1197  [1]
 LDCM0319  AC56 PaTu 8988t C202(1.26); C219(1.26)  LDD1198  [1]
 LDCM0320  AC57 PaTu 8988t C202(1.33); C219(1.33)  LDD1199  [1]
 LDCM0321  AC58 PaTu 8988t C202(1.00); C219(1.00)  LDD1200  [1]
 LDCM0322  AC59 PaTu 8988t C202(0.99); C219(0.99)  LDD1201  [1]
 LDCM0324  AC60 PaTu 8988t C202(0.90); C219(0.90)  LDD1203  [1]
 LDCM0325  AC61 PaTu 8988t C202(1.10); C219(1.10)  LDD1204  [1]
 LDCM0326  AC62 PaTu 8988t C202(0.90); C219(0.90)  LDD1205  [1]
 LDCM0327  AC63 PaTu 8988t C202(0.97); C219(0.97)  LDD1206  [1]
 LDCM0328  AC64 PaTu 8988t C202(1.16); C219(1.16)  LDD1207  [1]
 LDCM0329  AC65 PaTu 8988t C202(1.38); C219(1.38)  LDD1208  [1]
 LDCM0330  AC66 PaTu 8988t C202(1.22); C219(1.22)  LDD1209  [1]
 LDCM0331  AC67 PaTu 8988t C202(1.37); C219(1.37)  LDD1210  [1]
 LDCM0332  AC68 PaTu 8988t C202(1.37); C219(1.37)  LDD1211  [1]
 LDCM0333  AC69 PaTu 8988t C202(1.12); C219(1.12)  LDD1212  [1]
 LDCM0335  AC70 PaTu 8988t C202(1.43); C219(1.43)  LDD1214  [1]
 LDCM0336  AC71 PaTu 8988t C202(1.36); C219(1.36)  LDD1215  [1]
 LDCM0337  AC72 PaTu 8988t C202(0.98); C219(0.98)  LDD1216  [1]
 LDCM0338  AC73 PaTu 8988t C202(1.15); C219(1.15)  LDD1217  [1]
 LDCM0339  AC74 PaTu 8988t C202(1.14); C219(1.14)  LDD1218  [1]
 LDCM0340  AC75 PaTu 8988t C202(1.68); C219(1.68)  LDD1219  [1]
 LDCM0341  AC76 PaTu 8988t C202(1.22); C219(1.22)  LDD1220  [1]
 LDCM0342  AC77 PaTu 8988t C202(1.04); C219(1.04)  LDD1221  [1]
 LDCM0343  AC78 PaTu 8988t C202(1.20); C219(1.20)  LDD1222  [1]
 LDCM0344  AC79 PaTu 8988t C202(1.55); C219(1.55)  LDD1223  [1]
 LDCM0346  AC80 PaTu 8988t C202(1.49); C219(1.49)  LDD1225  [1]
 LDCM0347  AC81 PaTu 8988t C202(1.10); C219(1.10)  LDD1226  [1]
 LDCM0348  AC82 PaTu 8988t C202(1.19); C219(1.19)  LDD1227  [1]
 LDCM0349  AC83 PaTu 8988t C202(1.18); C219(1.18)  LDD1228  [1]
 LDCM0350  AC84 PaTu 8988t C202(0.77); C219(0.77)  LDD1229  [1]
 LDCM0351  AC85 PaTu 8988t C202(0.91); C219(0.91)  LDD1230  [1]
 LDCM0352  AC86 PaTu 8988t C202(0.74); C219(0.74)  LDD1231  [1]
 LDCM0353  AC87 PaTu 8988t C202(1.09); C219(1.09)  LDD1232  [1]
 LDCM0354  AC88 PaTu 8988t C202(0.93); C219(0.93)  LDD1233  [1]
 LDCM0355  AC89 PaTu 8988t C202(1.00); C219(1.00)  LDD1234  [1]
 LDCM0357  AC90 PaTu 8988t C202(1.26); C219(1.26)  LDD1236  [1]
 LDCM0358  AC91 PaTu 8988t C202(0.85); C219(0.85)  LDD1237  [1]
 LDCM0359  AC92 PaTu 8988t C202(0.73); C219(0.73)  LDD1238  [1]
 LDCM0360  AC93 PaTu 8988t C202(0.99); C219(0.99)  LDD1239  [1]
 LDCM0361  AC94 PaTu 8988t C202(0.74); C219(0.74)  LDD1240  [1]
 LDCM0362  AC95 PaTu 8988t C202(0.85); C219(0.85)  LDD1241  [1]
 LDCM0363  AC96 PaTu 8988t C202(0.73); C219(0.73)  LDD1242  [1]
 LDCM0364  AC97 PaTu 8988t C202(0.92); C219(0.92)  LDD1243  [1]
 LDCM0369  CL100 PaTu 8988t C202(1.50); C219(1.50)  LDD1248  [1]
 LDCM0374  CL105 PaTu 8988t C202(0.91); C219(0.91)  LDD1253  [1]
 LDCM0375  CL106 PaTu 8988t C202(1.17); C219(1.17)  LDD1254  [1]
 LDCM0376  CL107 PaTu 8988t C202(0.91); C219(0.91)  LDD1255  [1]
 LDCM0377  CL108 PaTu 8988t C202(1.22); C219(1.22)  LDD1256  [1]
 LDCM0378  CL109 PaTu 8988t C202(1.09); C219(1.09)  LDD1257  [1]
 LDCM0380  CL110 PaTu 8988t C202(1.16); C219(1.16)  LDD1259  [1]
 LDCM0381  CL111 PaTu 8988t C202(1.17); C219(1.17)  LDD1260  [1]
 LDCM0392  CL121 PaTu 8988t C202(1.65); C219(1.65)  LDD1271  [1]
 LDCM0393  CL122 PaTu 8988t C202(1.21); C219(1.21)  LDD1272  [1]
 LDCM0394  CL123 PaTu 8988t C202(2.16); C219(2.16)  LDD1273  [1]
 LDCM0395  CL124 PaTu 8988t C202(1.84); C219(1.84)  LDD1274  [1]
 LDCM0396  CL125 PaTu 8988t C202(0.89); C219(0.89)  LDD1275  [1]
 LDCM0397  CL126 PaTu 8988t C202(1.37); C219(1.37)  LDD1276  [1]
 LDCM0398  CL127 PaTu 8988t C202(1.21); C219(1.21)  LDD1277  [1]
 LDCM0399  CL128 PaTu 8988t C202(1.17); C219(1.17)  LDD1278  [1]
 LDCM0403  CL16 PaTu 8988t C202(1.19); C219(1.19)  LDD1282  [1]
 LDCM0404  CL17 PaTu 8988t C202(1.56); C219(1.56)  LDD1283  [1]
 LDCM0405  CL18 PaTu 8988t C202(0.92); C219(0.92)  LDD1284  [1]
 LDCM0406  CL19 PaTu 8988t C202(1.46); C219(1.46)  LDD1285  [1]
 LDCM0408  CL20 PaTu 8988t C202(1.09); C219(1.09)  LDD1287  [1]
 LDCM0409  CL21 PaTu 8988t C202(1.04); C219(1.04)  LDD1288  [1]
 LDCM0410  CL22 PaTu 8988t C202(1.38); C219(1.38)  LDD1289  [1]
 LDCM0411  CL23 PaTu 8988t C202(1.25); C219(1.25)  LDD1290  [1]
 LDCM0412  CL24 PaTu 8988t C202(1.26); C219(1.26)  LDD1291  [1]
 LDCM0413  CL25 PaTu 8988t C202(1.31); C219(1.31)  LDD1292  [1]
 LDCM0414  CL26 PaTu 8988t C202(1.08); C219(1.08)  LDD1293  [1]
 LDCM0415  CL27 PaTu 8988t C202(1.18); C219(1.18)  LDD1294  [1]
 LDCM0416  CL28 PaTu 8988t C202(1.34); C219(1.34)  LDD1295  [1]
 LDCM0417  CL29 PaTu 8988t C202(1.14); C219(1.14)  LDD1296  [1]
 LDCM0419  CL30 PaTu 8988t C202(1.17); C219(1.17)  LDD1298  [1]
 LDCM0486  CL91 PaTu 8988t C202(1.14); C219(1.14)  LDD1365  [1]
 LDCM0487  CL92 PaTu 8988t C202(1.54); C219(1.54)  LDD1366  [1]
 LDCM0488  CL93 PaTu 8988t C202(4.61); C219(4.61)  LDD1367  [1]
 LDCM0489  CL94 PaTu 8988t C202(3.69); C219(3.69)  LDD1368  [1]
 LDCM0490  CL95 PaTu 8988t C202(1.76); C219(1.76)  LDD1369  [1]
 LDCM0491  CL96 PaTu 8988t C202(2.03); C219(2.03)  LDD1370  [1]
 LDCM0492  CL97 PaTu 8988t C202(1.84); C219(1.84)  LDD1371  [1]
 LDCM0493  CL98 PaTu 8988t C202(1.46); C219(1.46)  LDD1372  [1]
 LDCM0494  CL99 PaTu 8988t C202(2.34); C219(2.34)  LDD1373  [1]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.