Details of the Target

General Information of Target

Target ID LDTP10342
Target Name Neurotrophin receptor-interacting factor homolog (ZNF274)
Gene Name ZNF274
Gene ID 10782
Synonyms
ZKSCAN19; Neurotrophin receptor-interacting factor homolog; Zinc finger protein 274; Zinc finger protein HFB101; Zinc finger protein with KRAB and SCAN domains 19; Zinc finger protein zfp2; Zf2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDGPVAEHAKQEPFHVVTPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMA
KKGCRHLVCSSGGNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTGKVW
DEANLRAQELAKRDGWENVPPFDHPLIWKGHASLVQELKAVLRTPPGALVLAVGGGGLLA
GVVAGLLEVGWQHVPIIAMETHGAHCFNAAITAGKLVTLPDITSVAKSLGAKTVAARALE
CMQVCKIHSEVVEDTEAVSAVQQLLDDERMLVEPACGAALAAIYSGLLRRLQAEGCLPPS
LTSVVVIVCGGNNINSRELQALKTHLGQV
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Cytoplasm
Function
Probable transcription repressor. Specifically binds to the 3'-end of zinc-finger coding genes and recruiting chromatin-modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression. The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions.
Uniprot ID
Q96GC6
Ensemble ID
ENST00000345813.7
HGNC ID
HGNC:13068

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO320 SNV: p.G305A .
MCC13 SNV: p.P100S .
MDAMB453 SNV: p.H605R .
MOLT4 SNV: p.V536M .
SNU423 SNV: p.Q191R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C361(1.12)  LDD1509  [1]
Acrolein
 Probe Info  		N.A.  LDD0217  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0226  AC11 HEK-293T C361(1.12)  LDD1509  [1]
 LDCM0270  AC15 HEK-293T C361(1.08)  LDD1513  [1]
 LDCM0278  AC19 HEK-293T C361(1.01)  LDD1517  [1]
 LDCM0283  AC23 HEK-293T C361(0.95)  LDD1522  [1]
 LDCM0287  AC27 HEK-293T C361(1.04)  LDD1526  [1]
 LDCM0290  AC3 HEK-293T C361(0.77)  LDD1529  [1]
 LDCM0292  AC31 HEK-293T C361(0.84)  LDD1531  [1]
 LDCM0296  AC35 HEK-293T C361(0.92)  LDD1535  [1]
 LDCM0300  AC39 HEK-293T C361(1.23)  LDD1539  [1]
 LDCM0305  AC43 HEK-293T C361(0.85)  LDD1544  [1]
 LDCM0309  AC47 HEK-293T C361(0.93)  LDD1548  [1]
 LDCM0314  AC51 HEK-293T C361(1.03)  LDD1553  [1]
 LDCM0318  AC55 HEK-293T C361(0.92)  LDD1557  [1]
 LDCM0322  AC59 HEK-293T C361(1.02)  LDD1561  [1]
 LDCM0327  AC63 HEK-293T C361(0.95)  LDD1566  [1]
 LDCM0334  AC7 HEK-293T C361(0.91)  LDD1568  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [2]
 LDCM0371  CL102 HEK-293T C361(0.90)  LDD1575  [1]
 LDCM0375  CL106 HEK-293T C361(0.86)  LDD1579  [1]
 LDCM0379  CL11 HEK-293T C361(1.16)  LDD1583  [1]
 LDCM0380  CL110 HEK-293T C361(0.82)  LDD1584  [1]
 LDCM0384  CL114 HEK-293T C361(0.88)  LDD1588  [1]
 LDCM0388  CL118 HEK-293T C361(0.93)  LDD1592  [1]
 LDCM0393  CL122 HEK-293T C361(0.99)  LDD1597  [1]
 LDCM0397  CL126 HEK-293T C361(0.85)  LDD1601  [1]
 LDCM0401  CL14 HEK-293T C361(0.72)  LDD1605  [1]
 LDCM0406  CL19 HEK-293T C361(1.05)  LDD1610  [1]
 LDCM0407  CL2 HEK-293T C361(1.02)  LDD1611  [1]
 LDCM0411  CL23 HEK-293T C361(1.17)  LDD1615  [1]
 LDCM0414  CL26 HEK-293T C361(0.96)  LDD1618  [1]
 LDCM0420  CL31 HEK-293T C361(1.11)  LDD1624  [1]
 LDCM0424  CL35 HEK-293T C361(1.03)  LDD1628  [1]
 LDCM0433  CL43 HEK-293T C361(0.92)  LDD1637  [1]
 LDCM0437  CL47 HEK-293T C361(0.94)  LDD1641  [1]
 LDCM0441  CL50 HEK-293T C361(0.64)  LDD1645  [1]
 LDCM0446  CL55 HEK-293T C361(0.97)  LDD1649  [1]
 LDCM0450  CL59 HEK-293T C361(0.82)  LDD1653  [1]
 LDCM0454  CL62 HEK-293T C361(0.89)  LDD1657  [1]
 LDCM0459  CL67 HEK-293T C361(0.83)  LDD1662  [1]
 LDCM0462  CL7 HEK-293T C361(1.21)  LDD1665  [1]
 LDCM0464  CL71 HEK-293T C361(1.00)  LDD1667  [1]
 LDCM0467  CL74 HEK-293T C361(0.76)  LDD1670  [1]
 LDCM0472  CL79 HEK-293T C361(0.89)  LDD1675  [1]
 LDCM0477  CL83 HEK-293T C361(1.03)  LDD1680  [1]
 LDCM0480  CL86 HEK-293T C361(0.88)  LDD1683  [1]
 LDCM0486  CL91 HEK-293T C361(1.08)  LDD1689  [1]
 LDCM0490  CL95 HEK-293T C361(0.86)  LDD1693  [1]
 LDCM0493  CL98 HEK-293T C361(1.24)  LDD1696  [1]
 LDCM0427  Fragment51 HEK-293T C361(1.01)  LDD1631  [1]
 LDCM0109  NEM HeLa N.A.  LDD0224  [2]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.