Details of the Target

General Information of Target

Target ID LDTP10302
Target Name Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 (LINGO1)
Gene Name LINGO1
Gene ID 84894
Synonyms
LERN1; LRRN6A; Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1; Leucine-rich repeat and immunoglobulin domain-containing protein 1; Leucine-rich repeat neuronal protein 1; Leucine-rich repeat neuronal protein 6A
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MANETQKVGAIHFPFPFTPYSIQEDFMAELYRVLEAGKIGIFESPTGTGKSLSLICGALS
WLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQK
KEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLET
GPEAERLEQLESGEEELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQLA
QFVHEVKKSPFGKDVRLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEKKKGAE
EEKPKRRRQEKQAACPFYNHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSRLAIP
AAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAHNLIDTITGMHSVEVSGSQLCQAHS
QLLQYVERYGKRLKAKNLMYLKQILYLLEKFVAVLGGNIKQNPNTQSLSQTGTELKTIND
FLFQSQIDNINLFKVQRYCEKSMISRKLFGFTERYGAVFSSREQPKLAGFQQFLQSLQPR
TTEALAAPADESQASTLRPASPLMHIQGFLAALTTANQDGRVILSRQGSLSQSTLKFLLL
NPAVHFAQVVKECRAVVIAGGTMQPVSDFRQQLLACAGVEAERVVEFSCGHVIPPDNILP
LVICSGISNQPLEFTFQKRELPQMMDEVGRILCNLCGVVPGGVVCFFPSYEYLRQVHAHW
EKGGLLGRLAARKKIFQEPKSAHQVEQVLLAYSRCIQACGQERGQVTGALLLSVVGGKMS
EGINFSDNLGRCVVMVGMPFPNIRSAELQEKMAYLDQTLSPRPGTPREGSGGEPVHEGRQ
PVHRQGHQAPEGFCQRSAPGPAICPAPCPGQAAGLDPSPCGGQSYLWPRHCCCAEVSPGE
VGLFLMGNHTTAWRRALPLSCPLETVFVVGVVCGDPVTKVKPRRRVWSPECCQDPGTGVS
SRRRKWGNPE
Target Type
Clinical trial
Target Bioclass
Immunoglobulin
Subcellular location
Cell membrane
Function
Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination. Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development.
TTD ID
T05643
Uniprot ID
Q96FE5
DrugMap ID
TTZYQ80
Ensemble ID
ENST00000355300.7
HGNC ID
HGNC:21205
ChEMBL ID
CHEMBL3712965

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CHL1 SNV: p.A455P .
CORL88 SNV: p.Y288F .
HCT15 SNV: p.P112T .
HT115 SNV: p.V219A .
JURKAT SNV: p.G37C; p.L78P .
NCIH2172 SNV: p.H440Y .
NCIH358 SNV: p.A455P .
SKNAS SNV: p.R515L .
SUPT1 SNV: p.T266M .
SW1271 SNV: p.L97M .
SW1783 SNV: p.R473Q .
TOV21G SNV: p.G320V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C57(2.06)  LDD3427  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0270  AC15 HEK-293T C421(1.03)  LDD1513  [2]
 LDCM0283  AC23 HEK-293T C421(0.96)  LDD1522  [2]
 LDCM0292  AC31 HEK-293T C421(0.97)  LDD1531  [2]
 LDCM0300  AC39 HEK-293T C421(0.92)  LDD1539  [2]
 LDCM0309  AC47 HEK-293T C421(1.01)  LDD1548  [2]
 LDCM0318  AC55 HEK-293T C421(1.06)  LDD1557  [2]
 LDCM0327  AC63 HEK-293T C421(1.16)  LDD1566  [2]
 LDCM0334  AC7 HEK-293T C421(0.99)  LDD1568  [2]
 LDCM0379  CL11 HEK-293T C421(1.14)  LDD1583  [2]
 LDCM0411  CL23 HEK-293T C421(1.10)  LDD1615  [2]
 LDCM0424  CL35 HEK-293T C421(1.04)  LDD1628  [2]
 LDCM0437  CL47 HEK-293T C421(0.98)  LDD1641  [2]
 LDCM0450  CL59 HEK-293T C421(1.01)  LDD1653  [2]
 LDCM0464  CL71 HEK-293T C421(1.12)  LDD1667  [2]
 LDCM0477  CL83 HEK-293T C421(0.97)  LDD1680  [2]
 LDCM0490  CL95 HEK-293T C421(0.92)  LDD1693  [2]
 LDCM0022  KB02 Hs 936.T C57(1.66)  LDD2363  [1]
 LDCM0023  KB03 Hs 936.T C57(1.80)  LDD2780  [1]
 LDCM0024  KB05 SK-MEL-28 C57(2.06)  LDD3427  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402