Details of the Target

General Information of Target

Target ID LDTP10259
Target Name Arylsulfatase G (ARSG)
Gene Name ARSG
Gene ID 22901
Synonyms
KIAA1001; Arylsulfatase G; ASG; EC 3.1.6.1; N-sulfoglucosamine-3-sulfatase; EC 3.1.6.15
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGARLSRRRLPADPSLALDALPPELLVQVLSHVPPRSLVTRCRPVCRAWRDIVDGPTVWL
LQLARDRSAEGRALYAVAQRCLPSNEDKEEFPLCALARYCLRAPFGRNLIFNSCGEQGFR
GWEVEHGGNGWAIEKNLTPVPGAPSQTCFVTSFEWCSKRQLVDLVMEGVWQELLDSAQIE
ICVADWWGARENCGCVYQLRVRLLDVYEKEVVKFSASPDPVLQWTERGCRQVSHVFTNFG
KGIRYVSFEQYGRDVSSWVGHYGALVTHSSVRVRIRLS
Target Bioclass
Enzyme
Family
Sulfatase family
Subcellular location
Lysosome
Function
Displays arylsulfatase activity at acidic pH towards artificial substrates, such as p-nitrocatechol sulfate and also, but with a lower activity towards p-nitrophenyl sulfate and 4-methylumbelliferyl sulfate. Catalyzes the hydrolysis of the 3-sulfate groups of the N-sulfo-D-glucosamine 3-O-sulfate units of heparin.
Uniprot ID
Q96EG1
Ensemble ID
ENST00000448504.6
HGNC ID
HGNC:24102
ChEMBL ID
CHEMBL2189124

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C310(1.00)  LDD1512  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0259  AC14 HEK-293T C310(1.00)  LDD1512  [1]
 LDCM0282  AC22 HEK-293T C310(1.16)  LDD1521  [1]
 LDCM0291  AC30 HEK-293T C310(0.98)  LDD1530  [1]
 LDCM0299  AC38 HEK-293T C310(0.98)  LDD1538  [1]
 LDCM0308  AC46 HEK-293T C310(0.92)  LDD1547  [1]
 LDCM0317  AC54 HEK-293T C310(0.93)  LDD1556  [1]
 LDCM0323  AC6 HEK-293T C310(1.02)  LDD1562  [1]
 LDCM0326  AC62 HEK-293T C310(0.79)  LDD1565  [1]
 LDCM0368  CL10 HEK-293T C310(1.29)  LDD1572  [1]
 LDCM0410  CL22 HEK-293T C310(1.83)  LDD1614  [1]
 LDCM0423  CL34 HEK-293T C310(1.05)  LDD1627  [1]
 LDCM0436  CL46 HEK-293T C310(1.31)  LDD1640  [1]
 LDCM0449  CL58 HEK-293T C310(1.30)  LDD1652  [1]
 LDCM0463  CL70 HEK-293T C310(1.23)  LDD1666  [1]
 LDCM0476  CL82 HEK-293T C310(1.20)  LDD1679  [1]
 LDCM0489  CL94 HEK-293T C310(1.04)  LDD1692  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402