Details of the Target

General Information of Target

Target ID LDTP10224
Target Name BPI fold-containing family A member 2 (BPIFA2)
Gene Name BPIFA2
Gene ID 140683
Synonyms
C20orf70; SPLUNC2; BPI fold-containing family A member 2; Parotid secretory protein; PSP; Short palate, lung and nasal epithelium carcinoma-associated protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEGLSDVASFATKLKNTLIQYHSIEEDKWRVAKKTKDVTVWRKPSEEFNGYLYKAQGVID
DLVYSIIDHIRPGPCRLDWDSLMTSLDILENFEENCCVMRYTTAGQLWNIISPREFVDFS
YTVGYKEGLLSCGISLDWDEKRPEFVRGYNHPCGWFCVPLKDNPNQSLLTGYIQTDLRGM
IPQSAVDTAMASTLTNFYGDLRKAL
Target Bioclass
Other
Family
BPI/LBP/Plunc superfamily, Plunc family
Subcellular location
Secreted
Function Has strong antibacterial activity against P. aeruginosa.
Uniprot ID
Q96DR5
Ensemble ID
ENST00000253362.6
HGNC ID
HGNC:16203

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C217(1.18)  LDD2182  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0625  F8 Ramos C217(0.62)  LDD2187  [1]
 LDCM0572  Fragment10 Ramos C217(0.75)  LDD2189  [1]
 LDCM0573  Fragment11 Ramos C217(0.59)  LDD2190  [1]
 LDCM0574  Fragment12 Ramos C217(1.10)  LDD2191  [1]
 LDCM0575  Fragment13 Ramos C217(0.71)  LDD2192  [1]
 LDCM0576  Fragment14 Ramos C217(1.38)  LDD2193  [1]
 LDCM0579  Fragment20 Ramos C217(0.95)  LDD2194  [1]
 LDCM0580  Fragment21 Ramos C217(0.87)  LDD2195  [1]
 LDCM0582  Fragment23 Ramos C217(0.78)  LDD2196  [1]
 LDCM0578  Fragment27 Ramos C217(0.71)  LDD2197  [1]
 LDCM0586  Fragment28 Ramos C217(0.59)  LDD2198  [1]
 LDCM0588  Fragment30 Ramos C217(1.02)  LDD2199  [1]
 LDCM0589  Fragment31 Ramos C217(0.71)  LDD2200  [1]
 LDCM0590  Fragment32 Ramos C217(1.15)  LDD2201  [1]
 LDCM0468  Fragment33 Ramos C217(0.99)  LDD2202  [1]
 LDCM0596  Fragment38 Ramos C217(0.76)  LDD2203  [1]
 LDCM0566  Fragment4 Ramos C217(1.14)  LDD2184  [1]
 LDCM0610  Fragment52 Ramos C217(0.62)  LDD2204  [1]
 LDCM0614  Fragment56 Ramos C217(0.56)  LDD2205  [1]
 LDCM0569  Fragment7 Ramos C217(1.54)  LDD2186  [1]
 LDCM0571  Fragment9 Ramos C217(1.04)  LDD2188  [1]
 LDCM0022  KB02 Ramos C217(1.18)  LDD2182  [1]
 LDCM0023  KB03 Ramos C217(2.98)  LDD2183  [1]
 LDCM0024  KB05 Ramos C217(2.33)  LDD2185  [1]

References

1 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578