Details of the Target

General Information of Target

Target ID LDTP10175
Target Name Zinc finger protein 653 (ZNF653)
Gene Name ZNF653
Gene ID 115950
Synonyms
ZIP67; Zinc finger protein 653; 67 kDa zinc finger protein; Zinc finger protein Zip67
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNSAAGFSHLDRRERVLKLGESFEKQPRCAFHTVRYDFKPASIDTSSEGYLEVGEGEQVT
ITLPNIEGSTPPVTVFKGSKKPYLKECILIINHDTGECRLEKLSSNITVKKTRVEGSSKI
QYRKEQQQQQMWNSARTPNLVKHSPSEDKMSPASPIDDIERELKAEASLMDQMSSCDSSS
DSKSSSSSSSEDSSSDSEDEDCKSSTSDTGNCVSGHPTMTQYRIPDIDASHNRFRDNSGL
LMNTLRNDLQLSESGSDSDD
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function Transcriptional repressor. May repress NR5A1, PPARG, NR1H3, NR4A2, ESR1 and NR3C1 transcriptional activity.
Uniprot ID
Q96CK0
Ensemble ID
ENST00000293771.10
HGNC ID
HGNC:25196

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C396(1.13)  LDD1509  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0226  AC11 HEK-293T C396(1.13)  LDD1509  [1]
 LDCM0270  AC15 HEK-293T C396(1.11)  LDD1513  [1]
 LDCM0278  AC19 HEK-293T C396(1.34)  LDD1517  [1]
 LDCM0281  AC21 HEK-293T C396(0.89)  LDD1520  [1]
 LDCM0283  AC23 HEK-293T C396(0.99)  LDD1522  [1]
 LDCM0287  AC27 HEK-293T C396(1.04)  LDD1526  [1]
 LDCM0289  AC29 HEK-293T C396(0.95)  LDD1528  [1]
 LDCM0290  AC3 HEK-293T C396(1.12)  LDD1529  [1]
 LDCM0292  AC31 HEK-293T C396(1.06)  LDD1531  [1]
 LDCM0296  AC35 HEK-293T C396(1.15)  LDD1535  [1]
 LDCM0298  AC37 HEK-293T C396(0.92)  LDD1537  [1]
 LDCM0300  AC39 HEK-293T C396(1.07)  LDD1539  [1]
 LDCM0305  AC43 HEK-293T C396(1.13)  LDD1544  [1]
 LDCM0307  AC45 HEK-293T C396(0.98)  LDD1546  [1]
 LDCM0309  AC47 HEK-293T C396(1.10)  LDD1548  [1]
 LDCM0312  AC5 HEK-293T C396(0.91)  LDD1551  [1]
 LDCM0314  AC51 HEK-293T C396(1.30)  LDD1553  [1]
 LDCM0316  AC53 HEK-293T C396(0.97)  LDD1555  [1]
 LDCM0318  AC55 HEK-293T C396(1.13)  LDD1557  [1]
 LDCM0322  AC59 HEK-293T C396(1.06)  LDD1561  [1]
 LDCM0325  AC61 HEK-293T C396(0.92)  LDD1564  [1]
 LDCM0327  AC63 HEK-293T C396(1.10)  LDD1566  [1]
 LDCM0334  AC7 HEK-293T C396(1.10)  LDD1568  [1]
 LDCM0248  AKOS034007472 HEK-293T C396(0.95)  LDD1511  [1]
 LDCM0379  CL11 HEK-293T C396(0.92)  LDD1583  [1]
 LDCM0406  CL19 HEK-293T C396(1.08)  LDD1610  [1]
 LDCM0409  CL21 HEK-293T C396(1.32)  LDD1613  [1]
 LDCM0411  CL23 HEK-293T C396(0.91)  LDD1615  [1]
 LDCM0420  CL31 HEK-293T C396(1.02)  LDD1624  [1]
 LDCM0422  CL33 HEK-293T C396(0.32)  LDD1626  [1]
 LDCM0424  CL35 HEK-293T C396(0.90)  LDD1628  [1]
 LDCM0433  CL43 HEK-293T C396(0.94)  LDD1637  [1]
 LDCM0435  CL45 HEK-293T C396(1.32)  LDD1639  [1]
 LDCM0437  CL47 HEK-293T C396(0.90)  LDD1641  [1]
 LDCM0446  CL55 HEK-293T C396(1.12)  LDD1649  [1]
 LDCM0448  CL57 HEK-293T C396(1.23)  LDD1651  [1]
 LDCM0450  CL59 HEK-293T C396(0.88)  LDD1653  [1]
 LDCM0459  CL67 HEK-293T C396(1.04)  LDD1662  [1]
 LDCM0461  CL69 HEK-293T C396(1.27)  LDD1664  [1]
 LDCM0462  CL7 HEK-293T C396(1.15)  LDD1665  [1]
 LDCM0464  CL71 HEK-293T C396(0.91)  LDD1667  [1]
 LDCM0472  CL79 HEK-293T C396(0.95)  LDD1675  [1]
 LDCM0475  CL81 HEK-293T C396(1.32)  LDD1678  [1]
 LDCM0477  CL83 HEK-293T C396(0.86)  LDD1680  [1]
 LDCM0484  CL9 HEK-293T C396(1.23)  LDD1687  [1]
 LDCM0486  CL91 HEK-293T C396(0.93)  LDD1689  [1]
 LDCM0488  CL93 HEK-293T C396(1.32)  LDD1691  [1]
 LDCM0490  CL95 HEK-293T C396(0.87)  LDD1693  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402