Details of the Target
General Information of Target
| Target ID | LDTP10168 | |||||
|---|---|---|---|---|---|---|
| Target Name | Inactive rhomboid protein 1 (RHBDF1) | |||||
| Gene Name | RHBDF1 | |||||
| Gene ID | 64285 | |||||
| Synonyms |
C16orf8; DIST1; IRHOM1; Inactive rhomboid protein 1; iRhom1; Epidermal growth factor receptor-related protein; Rhomboid 5 homolog 1; Rhomboid family member 1; p100hRho |
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| 3D Structure | ||||||
| Sequence |
MAALTLRGVRELLKRVDLATVPRRHRYKKKWAATEPKFPAVRLALQNFDMTYSVQFGDLW
PSIRVSLLSEQKYGALVNNFAAWDHVSAKLEQLSAKDFVNEAISHWELQSEGGQSAAPSP ASWACSPNLRCFTFDRGDISRFPPARPGSLGVMEYYLMDAASLLPVLALGLQPGDIVLDL CAAPGGKTLALLQTGCCRNLAANDLSPSRIARLQKILHSYVPEEIRDGNQVRVTSWDGRK WGELEGDTYDRVLVDVPCTTDRHSLHEEENNIFKRSRKKERQILPVLQVQLLAAGLLATK PGGHVVYSTCSLSHLQNEYVVQGAIELLANQYSIQVQVEDLTHFRRVFMDTFCFFSSCQV GELVIPNLMANFGPMYFCKMRRLT |
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| Target Bioclass |
Enzyme
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| Family |
Peptidase S54 family
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| Subcellular location |
Endoplasmic reticulum membrane
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| Function |
Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
AHL-Pu-1 Probe Info |
 |
C148(3.12) | LDD0171 | [1] | |
|
IPM Probe Info |
 |
C478(0.97) | LDD1701 | [2] | |
|
NAIA_4 Probe Info |
 |
N.A. | LDD2226 | [3] | |
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NAIA_5 Probe Info |
 |
N.A. | LDD2224 | [3] | |
|
Phosphinate-6 Probe Info |
 |
N.A. | LDD0018 | [4] | |
Competitor(s) Related to This Target
References