Details of the Target

General Information of Target

Target ID LDTP09981
Target Name Protein Wnt-2b (WNT2B)
Gene Name WNT2B
Gene ID 7482
Synonyms
WNT13; Protein Wnt-2b; Protein Wnt-13
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MARMNRPAPVEVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATYDTTLVEK
EGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKFREEPGCCIAVHCVAGLGRAPVLVALALI
EGGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRLRFKDSNGHRNNCCIQ
Target Bioclass
Other
Family
Wnt family
Subcellular location
Secreted, extracellular space, extracellular matrix
Function Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway. Plays a redundant role in embryonic lung development.
Uniprot ID
Q93097
Ensemble ID
ENST00000369684.5
HGNC ID
HGNC:12781

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AU565 SNV: p.S26L .
HCT116 SNV: p.M132I .
HEC1 SNV: p.R266W .
HEC1B SNV: p.R266W .
KMCH1 SNV: p.D178E .
LS123 SNV: p.N191T .
NCIH1155 SNV: p.A321T .
RVH421 SNV: p.R115H .
SNU308 SNV: p.R94C .
SUPT1 SNV: p.R266W .
SW1990 SNV: p.R197H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C107(0.93)  LDD1573  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0369  CL100 HEK-293T C107(0.93)  LDD1573  [1]
 LDCM0373  CL104 HEK-293T C107(1.00)  LDD1577  [1]
 LDCM0377  CL108 HEK-293T C107(1.03)  LDD1581  [1]
 LDCM0382  CL112 HEK-293T C107(1.03)  LDD1586  [1]
 LDCM0386  CL116 HEK-293T C107(1.05)  LDD1590  [1]
 LDCM0391  CL120 HEK-293T C107(1.08)  LDD1595  [1]
 LDCM0395  CL124 HEK-293T C107(1.10)  LDD1599  [1]
 LDCM0399  CL128 HEK-293T C107(1.08)  LDD1603  [1]
 LDCM0403  CL16 HEK-293T C107(1.12)  LDD1607  [1]
 LDCM0416  CL28 HEK-293T C107(0.97)  LDD1620  [1]
 LDCM0429  CL4 HEK-293T C107(1.00)  LDD1633  [1]
 LDCM0430  CL40 HEK-293T C107(0.86)  LDD1634  [1]
 LDCM0443  CL52 HEK-293T C107(1.19)  LDD1646  [1]
 LDCM0456  CL64 HEK-293T C107(1.06)  LDD1659  [1]
 LDCM0469  CL76 HEK-293T C107(0.98)  LDD1672  [1]
 LDCM0482  CL88 HEK-293T C107(0.91)  LDD1685  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402