Details of the Target
General Information of Target
| Target ID | LDTP09842 | |||||
|---|---|---|---|---|---|---|
| Target Name | Neurogranin (NRGN) |
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| Gene Name | NRGN | |||||
| Gene ID | 4900 | |||||
| Synonyms |
Neurogranin; Ng; RC3) [Cleaved into: NEUG(55-78)] |
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| 3D Structure | ||||||
| Sequence |
MAAGLRKRGRSGSAAQAEGLCKQWLQRAWQERRLLLREPRYTLLVAACLCLAEVGITFWV
IHRVAYTEIDWKAYMAEVEGVINGTYDYTQLQGDTGPLVYPAGFVYIFMGLYYATSRGTD IRMAQNIFAVLYLATLLLVFLIYHQTCKVPPFVFFFMCCASYRVHSIFVLRLFNDPVAMV LLFLSINLLLAQRWGWGCCFFSLAVSVKMNVLLFAPGLLFLLLTQFGFRGALPKLGICAG LQVVLGLPFLLENPSGYLSRSFDLGRQFLFHWTVNWRFLPEALFLHRAFHLALLTAHLTL LLLFALCRWHRTGESILSLLRDPSKRKVPPQPLTPNQIVSTLFTSNFIGICFSRSLHYQF YVWYFHTLPYLLWAMPARWLTHLLRLLVLGLIELSWNTYPSTSCSSAALHICHAVILLQL WLGPQPFPKSTQHSKKAH |
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| Target Bioclass |
Other
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| Family |
Neurogranin family
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| Function | Acts as a 'third messenger' substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium. | |||||
| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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C-Sul Probe Info |
 |
7.18 | LDD0066 | [1] | |
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STPyne Probe Info |
 |
K54(1.42) | LDD0277 | [2] | |
References