Details of the Target

General Information of Target

Target ID LDTP09736
Target Name Septin-1 (SEPTIN1)
Gene Name SEPTIN1
Gene ID 1731
Synonyms
DIFF6; PNUTL3; SEPT1; Septin-1; LARP; Peanut-like protein 3; Serologically defined breast cancer antigen NY-BR-24
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAGGVMDKEYVGFAALPNQLHRKSVKKGFDFTLMVAGESGLGKSTLINSLFLTNLYEDRQ
VPEASARLTQTLAIERRGVEIEEGGVKVKLTLVDTPGFGDSVDCSDCWLPVVKFIEEQFE
QYLRDESGLNRKNIQDSRVHCCLYFISPFGRGLRPLDVAFLRAVHEKVNIIPVIGKADAL
MPQETQALKQKIRDQLKEEEIHIYQFPECDSDEDEDFKRQDAEMKESIPFAVVGSCEVVR
DGGNRPVRGRRYSWGTVEVENPHHCDFLNLRRMLVQTHLQDLKEVTHDLLYEGYRARCLQ
SLARPGARDRASRSKLSRQSATEIPLPMLPLADTEKLIREKDEELRRMQEMLEKMQAQMQ
QSQAQGEQSDAL
Target Bioclass
Enzyme
Family
TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily, Septin GTPase family
Subcellular location
Cytoplasm
Function Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). {, }.
Uniprot ID
Q8WYJ6
Ensemble ID
ENST00000321367.8
HGNC ID
HGNC:2879

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K349(20.00)  LDD2219  [1]
DBIA
 Probe Info  		C260(11.60)  LDD0209  [2]
IA-alkyne
 Probe Info  		C236(0.00); C298(0.00)  LDD0166  [3]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [4]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [4]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-2
 Probe Info  		N.A.  LDD0139  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0625  F8 Ramos C298(0.99)  LDD2187  [6]
 LDCM0572  Fragment10 Ramos C298(1.03)  LDD2189  [6]
 LDCM0573  Fragment11 Ramos C298(0.12); C265(2.15)  LDD2190  [6]
 LDCM0574  Fragment12 Ramos C298(1.68)  LDD2191  [6]
 LDCM0575  Fragment13 Ramos C298(1.24)  LDD2192  [6]
 LDCM0576  Fragment14 Ramos C298(0.95); C265(0.62)  LDD2193  [6]
 LDCM0579  Fragment20 Ramos C298(1.73)  LDD2194  [6]
 LDCM0580  Fragment21 Ramos C298(1.12)  LDD2195  [6]
 LDCM0582  Fragment23 Ramos C298(1.37)  LDD2196  [6]
 LDCM0578  Fragment27 Ramos C298(1.04)  LDD2197  [6]
 LDCM0586  Fragment28 Ramos C298(0.79); C265(7.43)  LDD2198  [6]
 LDCM0588  Fragment30 Ramos C298(1.74)  LDD2199  [6]
 LDCM0589  Fragment31 Ramos C298(1.19)  LDD2200  [6]
 LDCM0590  Fragment32 Ramos C298(1.06)  LDD2201  [6]
 LDCM0468  Fragment33 Ramos C298(1.71)  LDD2202  [6]
 LDCM0596  Fragment38 Ramos C298(1.28)  LDD2203  [6]
 LDCM0566  Fragment4 Ramos C298(0.83); C265(2.37)  LDD2184  [6]
 LDCM0610  Fragment52 Ramos C298(1.64)  LDD2204  [6]
 LDCM0614  Fragment56 Ramos C298(1.56)  LDD2205  [6]
 LDCM0569  Fragment7 Ramos C298(0.52); C265(0.84)  LDD2186  [6]
 LDCM0571  Fragment9 Ramos C298(1.08)  LDD2188  [6]
 LDCM0022  KB02 T cell C99, C102(5.33); C260(12.92)  LDD1707  [7]
 LDCM0023  KB03 Jurkat C260(11.60)  LDD0209  [2]
 LDCM0024  KB05 NALM-6 C231(1.27)  LDD3339  [8]
 LDCM0131  RA190 MM1.R C293(1.36)  LDD0304  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
NIF3-like protein 1 (NIF3L1) GTP cyclohydrolase I type 2/NIF3 family Q9GZT8
Aurora kinase B (AURKB) Ser/Thr protein kinase family Q96GD4
Neuronal-specific septin-3 (SEPTIN3) Septin GTPase family Q9UH03
Septin-1 (SEPTIN1) Septin GTPase family Q8WYJ6
Septin-11 (SEPTIN11) Septin GTPase family Q9NVA2
Septin-12 (SEPTIN12) Septin GTPase family Q8IYM1
Septin-5 (SEPTIN5) Septin GTPase family Q99719
Septin-6 (SEPTIN6) Septin GTPase family Q14141
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Syntenin-1 (SDCBP) . O00560
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Large ribosomal subunit protein bL12m (MRPL12) Bacterial ribosomal protein bL12 family P52815
DNA damage-inducible transcript 4-like protein (DDIT4L) DDIT4 family Q96D03
Golgi reassembly-stacking protein 2 (GORASP2) GORASP family Q9H8Y8
PIH1 domain-containing protein 1 (PIH1D1) PIH1 family Q9NWS0
Testis-expressed protein 11 (TEX11) SPO22 family Q8IYF3
DnaJ homolog subfamily B member 13 (DNAJB13) . P59910
Heat shock factor 2-binding protein (HSF2BP) . O75031
PRKCA-binding protein (PICK1) . Q9NRD5

References

1 Global profiling of lysine reactivity and ligandability in the human proteome. Nat Chem. 2017 Dec;9(12):1181-1190. doi: 10.1038/nchem.2826. Epub 2017 Jul 31.
2 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
5 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
6 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
7 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
9 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.