Details of the Target

General Information of Target

Target ID LDTP09724
Target Name VPS10 domain-containing receptor SorCS1 (SORCS1)
Gene Name SORCS1
Gene ID 114815
Synonyms
SORCS; VPS10 domain-containing receptor SorCS1; hSorCS
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGKVGAGGGSQARLSALLAGAGLLILCAPGVCGGGSCCPSPHPSSAPRSASTPRGFSHQG
RPGRAPATPLPLVVRPLFSVAPGDRALSLERARGTGASMAVAARSGRRRRSGADQEKAER
GEGASRSPRGVLRDGGQQEPGTRERDPDKATRFRMEELRLTSTTFALTGDSAHNQAMVHW
SGHNSSVILILTKLYDYNLGSITESSLWRSTDYGTTYEKLNDKVGLKTILSYLYVCPTNK
RKIMLLTDPEIESSLLISSDEGATYQKYRLNFYIQSLLFHPKQEDWILAYSQDQKLYSSA
EFGRRWQLIQEGVVPNRFYWSVMGSNKEPDLVHLEARTVDGHSHYLTCRMQNCTEANRNQ
PFPGYIDPDSLIVQDHYVFVQLTSGGRPHYYVSYRRNAFAQMKLPKYALPKDMHVISTDE
NQVFAAVQEWNQNDTYNLYISDTRGVYFTLALENVQSSRGPEGNIMIDLYEVAGIKGMFL
ANKKIDNQVKTFITYNKGRDWRLLQAPDTDLRGDPVHCLLPYCSLHLHLKVSENPYTSGI
IASKDTAPSIIVASGNIGSELSDTDISMFVSSDAGNTWRQIFEEEHSVLYLDQGGVLVAM
KHTSLPIRHLWLSFDEGRSWSKYSFTSIPLFVDGVLGEPGEETLIMTVFGHFSHRSEWQL
VKVDYKSIFDRRCAEEDYRPWQLHSQGEACIMGAKRIYKKRKSERKCMQGKYAGAMESEP
CVCTEADFDCDYGYERHSNGQCLPAFWFNPSSLSKDCSLGQSYLNSTGYRKVVSNNCTDG
VREQYTAKPQKCPGKAPRGLRIVTADGKLTAEQGHNVTLMVQLEEGDVQRTLIQVDFGDG
IAVSYVNLSSMEDGIKHVYQNVGIFRVTVQVDNSLGSDSAVLYLHVTCPLEHVHLSLPFV
TTKNKEVNATAVLWPSQVGTLTYVWWYGNNTEPLITLEGSISFRFTSEGMNTITVQVSAG
NAILQDTKTIAVYEEFRSLRLSFSPNLDDYNPDIPEWRRDIGRVIKKSLVEATGVPGQHI
LVAVLPGLPTTAELFVLPYQDPAGENKRSTDDLEQISELLIHTLNQNSVHFELKPGVRVL
VHAAHLTAAPLVDLTPTHSGSAMLMLLSVVFVGLAVFVIYKFKRRVALPSPPSPSTQPGD
SSLRLQRARHATPPSTPKRGSAGAQYAI
Target Bioclass
Transporter and channel
Family
VPS10-related sortilin family, SORCS subfamily
Subcellular location
Membrane
Uniprot ID
Q8WY21
Ensemble ID
ENST00000263054.11
HGNC ID
HGNC:16697

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL62 SNV: p.Q283L .
CCSW1 SNV: p.E704K .
COLO678 SNV: p.A124V .
EFO27 SNV: p.E301Ter .
EGI1 SNV: p.A726T .
ETK1 SNV: p.F669S .
HCC1187 SNV: p.K223N .
HCC15 Deletion: p.P29RfsTer45 .
HCT116 Deletion: p.L800CfsTer3 .
HT SNV: p.H1085L .
JHH4 SNV: p.L167M .
JHH7 SNV: p.Q432Ter .
KYSE30 SNV: p.G949R .
LNCaP clone FGC SNV: p.L438I
Substitution: p.Y927C		 .
MEWO Substitution: p.G474K DBIA    Probe Info 
MFE319 SNV: p.R129L .
MOLT4 SNV: p.D514Y .
NALM6 Deletion: p.R129GfsTer4 .
NCIH1048 SNV: p.R75C .
NCIH2286 SNV: p.D664Y .
NCIH446 SNV: p.L764I .
OVK18 SNV: p.G55S .
PC9 SNV: p.R696M .
RAMOS SNV: p.D1041G .
RKO SNV: p.A426V .
SNGM SNV: p.R91L .
SNU449 SNV: p.G385R .
SNU5 SNV: p.K219T .
SW1271 SNV: p.P639A; p.E717V; p.P1096Q .
SW837 SNV: p.A1043D .
TE11 SNV: p.L612F .
WM1552C SNV: p.G83W .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		3.30  LDD0318  [1]
DBIA
 Probe Info  		C236(3.56)  LDD3404  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C236(0.96)  LDD1508  [3]
 LDCM0226  AC11 HEK-293T C236(0.96)  LDD1509  [3]
 LDCM0277  AC18 HEK-293T C236(0.97)  LDD1516  [3]
 LDCM0278  AC19 HEK-293T C236(0.93)  LDD1517  [3]
 LDCM0279  AC2 HEK-293T C236(0.94)  LDD1518  [3]
 LDCM0286  AC26 HEK-293T C236(1.07)  LDD1525  [3]
 LDCM0287  AC27 HEK-293T C236(0.91)  LDD1526  [3]
 LDCM0290  AC3 HEK-293T C236(1.03)  LDD1529  [3]
 LDCM0295  AC34 HEK-293T C236(1.03)  LDD1534  [3]
 LDCM0296  AC35 HEK-293T C236(1.02)  LDD1535  [3]
 LDCM0304  AC42 HEK-293T C236(1.07)  LDD1543  [3]
 LDCM0305  AC43 HEK-293T C236(0.99)  LDD1544  [3]
 LDCM0313  AC50 HEK-293T C236(0.89)  LDD1552  [3]
 LDCM0314  AC51 HEK-293T C236(0.99)  LDD1553  [3]
 LDCM0321  AC58 HEK-293T C236(0.97)  LDD1560  [3]
 LDCM0322  AC59 HEK-293T C236(1.02)  LDD1561  [3]
 LDCM0405  CL18 HEK-293T C236(1.07)  LDD1609  [3]
 LDCM0406  CL19 HEK-293T C236(0.98)  LDD1610  [3]
 LDCM0419  CL30 HEK-293T C236(0.96)  LDD1623  [3]
 LDCM0420  CL31 HEK-293T C236(0.98)  LDD1624  [3]
 LDCM0432  CL42 HEK-293T C236(0.95)  LDD1636  [3]
 LDCM0433  CL43 HEK-293T C236(0.93)  LDD1637  [3]
 LDCM0445  CL54 HEK-293T C236(1.09)  LDD1648  [3]
 LDCM0446  CL55 HEK-293T C236(0.99)  LDD1649  [3]
 LDCM0451  CL6 HEK-293T C236(1.01)  LDD1654  [3]
 LDCM0458  CL66 HEK-293T C236(1.16)  LDD1661  [3]
 LDCM0459  CL67 HEK-293T C236(0.92)  LDD1662  [3]
 LDCM0462  CL7 HEK-293T C236(1.02)  LDD1665  [3]
 LDCM0471  CL78 HEK-293T C236(1.08)  LDD1674  [3]
 LDCM0472  CL79 HEK-293T C236(0.87)  LDD1675  [3]
 LDCM0485  CL90 HEK-293T C236(1.22)  LDD1688  [3]
 LDCM0486  CL91 HEK-293T C236(0.95)  LDD1689  [3]
 LDCM0022  KB02 A2058 C348(1.87)  LDD2253  [2]
 LDCM0023  KB03 A2058 C236(3.84); C348(2.15)  LDD2670  [2]
 LDCM0024  KB05 SJRH30 C236(3.56)  LDD3404  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sortilin (SORT1) VPS10-related sortilin family Q99523

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402