Details of the Target

General Information of Target

Target ID LDTP09714
Target Name Myosin-IIIb (MYO3B)
Gene Name MYO3B
Gene ID 140469
Synonyms
Myosin-IIIb; EC 2.7.11.1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKHLYGLFHYNPMMLGLESLPDPTDTWEIIETIGKGTYGKVYKVTNKRDGSLAAVKILDP
VSDMDEEIEAEYNILQFLPNHPNVVKFYGMFYKADHCVGGQLWLVLELCNGGSVTELVKG
LLRCGQRLDEAMISYILYGALLGLQHLHNNRIIHRDVKGNNILLTTEGGVKLVDFGVSAQ
LTSTRLRRNTSVGTPFWMAPEVIACEQQYDSSYDARCDVWSLGITAIELGDGDPPLFDMH
PVKTLFKIPRNPPPTLLHPEKWCEEFNHFISQCLIKDFERRPSVTHLLDHPFIKGVHGKV
LFLQKQLAKVLQDQKHQNPVAKTRHERMHTRRPYHVEDAEKYCLEDDLVNLEVLDEDTII
HQLQKRYADLLIYTYVGDILIALNPFQNLSIYSPQFSRLYHGVKRASNPPHIFASADAAY
QCMVTLSKDQCIVISGESGSGKTESAHLIVQHLTFLGKANNQTLREKILQVNSLVEAFGN
SCTAINDNSSRFGKYLEMMFTPTGVVMGARISEYLLEKSRVIKQAAREKNFHIFYYIYAG
LHHQKKLSDFRLPEEKPPRYIADETGRVMHDITSKESYRRQFEAIQHCFRIIGFTDKEVH
SVYRILAGILNIGNIEFAAISSQHQTDKSEVPNAEALQNAASVLCISPEELQEALTSHCV
VTRGETIIRANTVDRAADVRDAMSKALYGRLFSWIVNRINTLLQPDENICSAGGGMNVGI
LDIFGFENFQRNSFEQLCINIANEQIQYYFNQHVFALEQMEYQNEGIDAVPVEYEDNRPL
LDMFLQKPLGLLALLDEESRFPQATDQTLVDKFEDNLRCKYFWRPKGVELCFGIQHYAGK
VLYDASGVLEKNRDTLPADVVVVLRTSENKLLQQLFSIPLTKTGNLAQTRARITVASSSL
PPHFSAGKAKVDTLEVIRHPEETTNMKRQTVASYFRYSLMDLLSKMVVGQPHFVRCIKPN
DDREALQFSRERVLAQLRSTGILETVSIRRQGYSHRILFEEFVKRYYYLAFTAHQTPLAS
KESCVAILEKSRLDHWVLGKTKVFLKYYHVEQLNLLLREVIGRVVVLQAYTKGWLGARRY
KRVREKREKGAIAIQSAWRGYDARRKFKKISNRRNESAAHNQAGDTSNQSSGPHSPVAAG
TRGSAEVQDCSEPGDHKVLRGSVHRRSHSQAESNNGRTQTSSNSPAVTEKNGHSQAQSSP
KGCDIFAGHANKHSVSGTDLLSSRICHPAPDQQGLSLWGAPQKPGSENGLAQKHRTPRRR
CQQPKMLSSPEDTMYYNQLNGTLEYQGSKRKPRKLGQIKVLDGEDEYYKSLSPVDCIPEE
NNSAHPSFFSSSSKGDSFAQH
Target Bioclass
Enzyme
Family
TRAFAC class myosin-kinesin ATPase superfamily, Myosin family; Protein kinase superfamily, STE Ser/Thr protein kinase family
Subcellular location
Cytoplasm, cytoskeleton
Function
Probable actin-based motor with a protein kinase activity. Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern. Involved in the elongation of actin in stereocilia tips by transporting the actin regulatory factor ESPN to the plus ends of actin filaments.
Uniprot ID
Q8WXR4
Ensemble ID
ENST00000317935.10
HGNC ID
HGNC:15576
ChEMBL ID
CHEMBL5654

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
42MGBA SNV: p.L287V .
786O SNV: p.A1324V .
CCK81 Deletion: p.H411TfsTer38
Substitution: p.V1037A		 .
CHL1 SNV: p.S1182N .
DEL SNV: p.A712E .
IGROV1 SNV: p.I609T .
Ishikawa (Heraklio) 02 ER Deletion: p.N1191MfsTer45 .
KPNYN SNV: p.T182I .
LS180 SNV: p.D815E .
MFE296 Deletion: p.S1330LfsTer102 .
MFE319 SNV: p.S1020N .
MIAPACA2 SNV: p.L637S .
MV411 SNV: p.G377V .
NCIH2286 SNV: p.A321S; p.N743S .
RH30 SNV: p.T166I .
RPMI8226 SNV: p.Y774H .
SNGM SNV: p.M760L .
SNU1 SNV: p.Q1015Ter .
TE4 SNV: p.Y843F .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C1212(3.00)  LDD3387  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0237  AC12 HEK-293T C431(0.95)  LDD1510  [2]
 LDCM0280  AC20 HEK-293T C431(1.05)  LDD1519  [2]
 LDCM0288  AC28 HEK-293T C431(1.23)  LDD1527  [2]
 LDCM0297  AC36 HEK-293T C431(1.35)  LDD1536  [2]
 LDCM0301  AC4 HEK-293T C431(1.08)  LDD1540  [2]
 LDCM0306  AC44 HEK-293T C431(1.41)  LDD1545  [2]
 LDCM0315  AC52 HEK-293T C431(1.24)  LDD1554  [2]
 LDCM0324  AC60 HEK-293T C431(0.97)  LDD1563  [2]
 LDCM0372  CL103 HEK-293T C431(1.19)  LDD1576  [2]
 LDCM0376  CL107 HEK-293T C431(1.00)  LDD1580  [2]
 LDCM0381  CL111 HEK-293T C431(0.95)  LDD1585  [2]
 LDCM0385  CL115 HEK-293T C431(1.12)  LDD1589  [2]
 LDCM0389  CL119 HEK-293T C431(1.14)  LDD1593  [2]
 LDCM0394  CL123 HEK-293T C431(1.09)  LDD1598  [2]
 LDCM0398  CL127 HEK-293T C431(0.99)  LDD1602  [2]
 LDCM0402  CL15 HEK-293T C431(1.07)  LDD1606  [2]
 LDCM0408  CL20 HEK-293T C431(1.32)  LDD1612  [2]
 LDCM0415  CL27 HEK-293T C431(0.95)  LDD1619  [2]
 LDCM0418  CL3 HEK-293T C431(1.22)  LDD1622  [2]
 LDCM0421  CL32 HEK-293T C431(1.16)  LDD1625  [2]
 LDCM0428  CL39 HEK-293T C431(1.18)  LDD1632  [2]
 LDCM0434  CL44 HEK-293T C431(1.27)  LDD1638  [2]
 LDCM0447  CL56 HEK-293T C431(1.32)  LDD1650  [2]
 LDCM0455  CL63 HEK-293T C431(1.15)  LDD1658  [2]
 LDCM0460  CL68 HEK-293T C431(1.15)  LDD1663  [2]
 LDCM0473  CL8 HEK-293T C431(1.18)  LDD1676  [2]
 LDCM0474  CL80 HEK-293T C431(1.27)  LDD1677  [2]
 LDCM0481  CL87 HEK-293T C431(1.17)  LDD1684  [2]
 LDCM0487  CL92 HEK-293T C431(1.31)  LDD1690  [2]
 LDCM0494  CL99 HEK-293T C431(0.99)  LDD1697  [2]
 LDCM0495  E2913 HEK-293T C431(1.05)  LDD1698  [2]
 LDCM0468  Fragment33 HEK-293T C431(1.01)  LDD1671  [2]
 LDCM0022  KB02 A2780 C1212(1.31)  LDD2254  [1]
 LDCM0023  KB03 A2780 C1212(1.60)  LDD2671  [1]
 LDCM0024  KB05 OVKATE C1212(3.00)  LDD3387  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402