Details of the Target
General Information of Target
| Target ID | LDTP09689 | |||||
|---|---|---|---|---|---|---|
| Target Name | Secretogranin-3 (SCG3) | |||||
| Gene Name | SCG3 | |||||
| Gene ID | 29106 | |||||
| Synonyms |
Secretogranin-3; Secretogranin III; SgIII |
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| 3D Structure | ||||||
| Sequence |
MGFLGTGTWILVLVLPIQAFPKPGGSQDKSLHNRELSAERPLNEQIAEAEEDKIKKTYPP
ENKPGQSNYSFVDNLNLLKAITEKEKIEKERQSIRSSPLDNKLNVEDVDSTKNRKLIDDY DSTKSGLDHKFQDDPDGLHQLDGTPLTAEDIVHKIAARIYEENDRAVFDKIVSKLLNLGL ITESQAHTLEDEVAEVLQKLISKEANNYEEDPNKPTSWTENQAGKIPEKVTPMAAIQDGL AKGENDETVSNTLTLTNGLERRTKTYSEDNFEELQYFPNFYALLKSIDSEKEAKEKETLI TIMKTLIDFVKMMVKYGTISPEEGVSYLENLDEMIALQTKNKLEKNATDNISKLFPAPSE KSHEETDSTKEEAAKMEKEYGSLKDSTKDDNSNPGGKTDEPKGKTEAYLEAIRKNIEWLK KHDKKGNKEDYDLSKMRDFINKQADAYVEKGILDKEEAEAIKRIYSSL |
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| Target Type |
Literature-reported
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| Target Bioclass |
Other
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| Subcellular location |
Cytoplasmic vesicle, secretory vesicle
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| Function |
Member of the granin protein family that regulates the biogenesis of secretory granules. Acts as a sorting receptor for intragranular proteins including chromogranin A/CHGA. May also play a role in angiogenesis. Promotes endothelial proliferation, migration and tube formation through MEK/ERK signaling pathway.
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| TTD ID | ||||||
| Uniprot ID | ||||||
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Target Site Mutations in Different Cell Lines
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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FBPP2 Probe Info |
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3,620.23 | LDD0318 | [1] | |
The Interaction Atlas With This Target