Details of the Target

General Information of Target

Target ID LDTP09532
Target Name Monocarboxylate transporter 10 (SLC16A10)
Gene Name SLC16A10
Gene ID 117247
Synonyms
MCT10; TAT1; Monocarboxylate transporter 10; MCT 10; Aromatic amino acid transporter 1; Solute carrier family 16 member 10; T-type amino acid transporter 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVLSQEEPDSARGTSEAQPLGPAPTGAAPPPGPGPSDSPEAAVEKVEVELAGPATAEPHE
PPEPPEGGWGWLVMLAAMWCNGSVFGIQNACGVLFVSMLETFGSKDDDKMVFKTAWVGSL
SMGMIFFCCPIVSVFTDLFGCRKTAVVGAAVGFVGLMSSSFVSSIEPLYLTYGIIFACGC
SFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTILLPLLLRVLIDSVGLFYTLRVLCIF
MFVLFLAGFTYRPLATSTKDKESGGSGSSLFSRKKFSPPKKIFNFAIFKVTAYAVWAVGI
PLALFGYFVPYVHLMKHVNERFQDEKNKEVVLMCIGVTSGVGRLLFGRIADYVPGVKKVY
LQVLSFFFIGLMSMMIPLCSIFGALIAVCLIMGLFDGCFISIMAPIAFELVGAQDVSQAI
GFLLGFMSIPMTVGPPIAGLLRDKLGSYDVAFYLAGVPPLIGGAVLCFIPWIHSKKQREI
SKTTGKEKMEKMLENQNSLLSSSSGMFKKESDSII
Target Bioclass
Transporter and channel
Family
Major facilitator superfamily, Monocarboxylate porter (TC 2.A.1.13) family
Subcellular location
Cell membrane
Function
Sodium- and proton-independent thyroid hormones and aromatic acids transporter. Mediates both uptake and efflux of 3,5,3'-triiodothyronine (T3) and 3,5,3',5'-tetraiodothyronine (T4) with high affinity, suggesting a role in the homeostasis of thyroid hormone levels. Responsible for low affinity bidirectional transport of the aromatic amino acids, such as phenylalanine, tyrosine, tryptophan and L-3,4-dihydroxyphenylalanine (L-dopa). Plays an important role in homeostasis of aromatic amino acids.
Uniprot ID
Q8TF71
Ensemble ID
ENST00000368851.10
HGNC ID
HGNC:17027

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C334(1.07)  LDD1507  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C334(1.07)  LDD1507  [1]
 LDCM0215  AC10 HEK-293T C334(1.08)  LDD1508  [1]
 LDCM0226  AC11 HEK-293T C334(1.05)  LDD1509  [1]
 LDCM0270  AC15 HEK-293T C334(1.05)  LDD1513  [1]
 LDCM0276  AC17 HEK-293T C334(0.97)  LDD1515  [1]
 LDCM0277  AC18 HEK-293T C334(0.99)  LDD1516  [1]
 LDCM0278  AC19 HEK-293T C334(0.89)  LDD1517  [1]
 LDCM0279  AC2 HEK-293T C334(1.08)  LDD1518  [1]
 LDCM0281  AC21 HEK-293T C334(1.04)  LDD1520  [1]
 LDCM0283  AC23 HEK-293T C334(0.99)  LDD1522  [1]
 LDCM0285  AC25 HEK-293T C334(1.03)  LDD1524  [1]
 LDCM0286  AC26 HEK-293T C334(0.99)  LDD1525  [1]
 LDCM0287  AC27 HEK-293T C334(1.15)  LDD1526  [1]
 LDCM0289  AC29 HEK-293T C334(0.90)  LDD1528  [1]
 LDCM0290  AC3 HEK-293T C334(1.11)  LDD1529  [1]
 LDCM0292  AC31 HEK-293T C334(0.97)  LDD1531  [1]
 LDCM0294  AC33 HEK-293T C334(1.02)  LDD1533  [1]
 LDCM0295  AC34 HEK-293T C334(1.03)  LDD1534  [1]
 LDCM0296  AC35 HEK-293T C334(0.95)  LDD1535  [1]
 LDCM0298  AC37 HEK-293T C334(0.90)  LDD1537  [1]
 LDCM0300  AC39 HEK-293T C334(0.84)  LDD1539  [1]
 LDCM0303  AC41 HEK-293T C334(1.02)  LDD1542  [1]
 LDCM0304  AC42 HEK-293T C334(1.09)  LDD1543  [1]
 LDCM0305  AC43 HEK-293T C334(1.07)  LDD1544  [1]
 LDCM0307  AC45 HEK-293T C334(0.88)  LDD1546  [1]
 LDCM0309  AC47 HEK-293T C334(0.98)  LDD1548  [1]
 LDCM0311  AC49 HEK-293T C334(0.97)  LDD1550  [1]
 LDCM0312  AC5 HEK-293T C334(0.89)  LDD1551  [1]
 LDCM0313  AC50 HEK-293T C334(1.10)  LDD1552  [1]
 LDCM0314  AC51 HEK-293T C334(1.07)  LDD1553  [1]
 LDCM0316  AC53 HEK-293T C334(0.95)  LDD1555  [1]
 LDCM0318  AC55 HEK-293T C334(1.04)  LDD1557  [1]
 LDCM0320  AC57 HEK-293T C334(1.01)  LDD1559  [1]
 LDCM0321  AC58 HEK-293T C334(1.07)  LDD1560  [1]
 LDCM0322  AC59 HEK-293T C334(1.15)  LDD1561  [1]
 LDCM0325  AC61 HEK-293T C334(1.02)  LDD1564  [1]
 LDCM0327  AC63 HEK-293T C334(0.99)  LDD1566  [1]
 LDCM0334  AC7 HEK-293T C334(0.94)  LDD1568  [1]
 LDCM0248  AKOS034007472 HEK-293T C334(0.94)  LDD1511  [1]
 LDCM0356  AKOS034007680 HEK-293T C334(0.97)  LDD1570  [1]
 LDCM0379  CL11 HEK-293T C334(0.81)  LDD1583  [1]
 LDCM0404  CL17 HEK-293T C334(0.98)  LDD1608  [1]
 LDCM0405  CL18 HEK-293T C334(1.04)  LDD1609  [1]
 LDCM0406  CL19 HEK-293T C334(1.05)  LDD1610  [1]
 LDCM0409  CL21 HEK-293T C334(0.85)  LDD1613  [1]
 LDCM0411  CL23 HEK-293T C334(0.90)  LDD1615  [1]
 LDCM0417  CL29 HEK-293T C334(0.88)  LDD1621  [1]
 LDCM0419  CL30 HEK-293T C334(0.83)  LDD1623  [1]
 LDCM0420  CL31 HEK-293T C334(0.89)  LDD1624  [1]
 LDCM0422  CL33 HEK-293T C334(0.92)  LDD1626  [1]
 LDCM0424  CL35 HEK-293T C334(1.09)  LDD1628  [1]
 LDCM0431  CL41 HEK-293T C334(0.85)  LDD1635  [1]
 LDCM0432  CL42 HEK-293T C334(0.90)  LDD1636  [1]
 LDCM0433  CL43 HEK-293T C334(0.99)  LDD1637  [1]
 LDCM0435  CL45 HEK-293T C334(0.89)  LDD1639  [1]
 LDCM0437  CL47 HEK-293T C334(0.89)  LDD1641  [1]
 LDCM0440  CL5 HEK-293T C334(1.14)  LDD1644  [1]
 LDCM0444  CL53 HEK-293T C334(0.92)  LDD1647  [1]
 LDCM0445  CL54 HEK-293T C334(0.85)  LDD1648  [1]
 LDCM0446  CL55 HEK-293T C334(0.93)  LDD1649  [1]
 LDCM0448  CL57 HEK-293T C334(0.97)  LDD1651  [1]
 LDCM0450  CL59 HEK-293T C334(1.00)  LDD1653  [1]
 LDCM0451  CL6 HEK-293T C334(1.12)  LDD1654  [1]
 LDCM0457  CL65 HEK-293T C334(0.98)  LDD1660  [1]
 LDCM0458  CL66 HEK-293T C334(0.99)  LDD1661  [1]
 LDCM0459  CL67 HEK-293T C334(0.84)  LDD1662  [1]
 LDCM0461  CL69 HEK-293T C334(0.85)  LDD1664  [1]
 LDCM0462  CL7 HEK-293T C334(1.09)  LDD1665  [1]
 LDCM0464  CL71 HEK-293T C334(0.97)  LDD1667  [1]
 LDCM0470  CL77 HEK-293T C334(1.02)  LDD1673  [1]
 LDCM0471  CL78 HEK-293T C334(1.01)  LDD1674  [1]
 LDCM0472  CL79 HEK-293T C334(1.12)  LDD1675  [1]
 LDCM0475  CL81 HEK-293T C334(0.87)  LDD1678  [1]
 LDCM0477  CL83 HEK-293T C334(1.03)  LDD1680  [1]
 LDCM0483  CL89 HEK-293T C334(1.02)  LDD1686  [1]
 LDCM0484  CL9 HEK-293T C334(0.94)  LDD1687  [1]
 LDCM0485  CL90 HEK-293T C334(1.02)  LDD1688  [1]
 LDCM0486  CL91 HEK-293T C334(1.02)  LDD1689  [1]
 LDCM0488  CL93 HEK-293T C334(0.99)  LDD1691  [1]
 LDCM0490  CL95 HEK-293T C334(0.87)  LDD1693  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402