Details of the Target

General Information of Target

Target ID LDTP09506
Target Name Sushi, nidogen and EGF-like domain-containing protein 1 (SNED1)
Gene Name SNED1
Gene ID 25992
Synonyms
Sushi, nidogen and EGF-like domain-containing protein 1; Insulin-responsive sequence DNA-binding protein 1; IRE-BP1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRHGVAWALLVAAALGLGARGVRGAVALADFYPFGAERGDAVTPKQDDGGSGLRPLSVPF
PFFGAEHSGLYVNNNGIISFLKEVSQFTPVAFPIAKDRCVVAAFWADVDNRRAGDVYYRE
ATDPAMLRRATEDVRHYFPELLDFNATWVFVATWYRVTFFGGSSSSPVNTFQTVLITDGK
LSFTIFNYESIVWTTGTHASSGGNATGLGGIAAQAGFNAGDGQRYFSIPGSRTADMAEVE
TTTNVGVPGRWAFRIDDAQVRVGGCGHTTSVCLALRPCLNGGKCIDDCVTGNPSYTCSCL
SGFTGRRCHLDVNECASQPCQNGGTCTHGINSFRCQCPAGFGGPTCETAQSPCDTKECQH
GGQCQVENGSAVCVCQAGYTGAACEMDVDDCSPDPCLNGGSCVDLVGNYTCLCAEPFKGL
RCETGDHPVPDACLSAPCHNGGTCVDADQGYVCECPEGFMGLDCRERVPDDCECRNGGRC
LGANTTLCQCPLGFFGLLCEFEITAMPCNMNTQCPDGGYCMEHGGSYLCVCHTDHNASHS
LPSPCDSDPCFNGGSCDAHDDSYTCECPRGFHGKHCEKARPHLCSSGPCRNGGTCKEAGG
EYHCSCPYRFTGRHCEIGKPDSCASGPCHNGGTCFHYIGKYKCDCPPGFSGRHCEIAPSP
CFRSPCVNGGTCEDRDTDFFCHCQAGYMGRRCQAEVDCGPPEEVKHATLRFNGTRLGAVA
LYACDRGYSLSAPSRIRVCQPHGVWSEPPQCLEIDECRSQPCLHGGSCQDRVAGYLCLCS
TGYEGAHCELERDECRAHPCRNGGSCRNLPGAYVCRCPAGFVGVHCETEVDACDSSPCQH
GGRCESGGGAYLCVCPESFFGYHCETVSDPCFSSPCGGRGYCLASNGSHSCTCKVGYTGE
DCAKELFPPTALKMERVEESGVSISWNPPNGPAARQMLDGYAVTYVSSDGSYRRTDFVDR
TRSSHQLQALAAGRAYNISVFSVKRNSNNKNDISRPAVLLARTRPRPVEGFEVTNVTAST
ISVQWALHRIRHATVSGVRVSIRHPEALRDQATDVDRSVDRFTFRALLPGKRYTIQLTTL
SGLRGEEHPTESLATAPTHVWTRPLPPANLTAARVTATSAHVVWDAPTPGSLLEAYVINV
TTSQSTKSRYVPNGKLASYTVRDLLPGRRYQLSVIAVQSTELGPQHSEPAHLYIITSPRD
GADRRWHQGGHHPRVLKNRPPPARLPELRLLNDHSAPETPTQPPRFSELVDGRGRVSARF
GGSPSKAATVRSQPTASAQLENMEEAPKRVSLALQLPEHGSKDIGNVPGNCSENPCQNGG
TCVPGADAHSCDCGPGFKGRRCELACIKVSRPCTRLFSETKAFPVWEGGVCHHVYKRVYR
VHQDICFKESCESTSLKKTPNRKQSKSQTLEKS
Target Bioclass
Other
Subcellular location
Secreted, extracellular space, extracellular matrix
Uniprot ID
Q8TER0
Ensemble ID
ENST00000310397.13
HGNC ID
HGNC:24696

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
8305C SNV: p.A975V .
AN3CA SNV: p.N1139D .
CCK81 SNV: p.V247M .
CCLP1 SNV: p.D404V .
COLO320 SNV: p.Y941Ter .
COLO792 SNV: p.S586L .
HEC1 SNV: p.G743S .
HEC1B SNV: p.G743S .
IPC298 SNV: p.Y527S .
Ishikawa (Heraklio) 02 ER Insertion: p.R879PfsTer61 .
L428 SNV: p.P428L .
LNCaP clone FGC Deletion: p.F860del .
MEWO SNV: p.R276P .
MFE319 Insertion: p.T1239NfsTer60 .
NALM6 SNV: p.V1008M .
NCIH1155 SNV: p.V814I; p.H1212N; p.C1316Y .
OCUG1 SNV: p.K1217N .
PC3 Substitution: p.Q1242P .
RH30 SNV: p.R1219S .
RL SNV: p.T296P .
SKMM2 SNV: p.V719G .
SNU1 SNV: p.P1007H .
SUIT2 SNV: p.R916T .
WM2664 Insertion: p.H582TfsTer35 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C-Sul
 Probe Info  		7.10  LDD0066  [1]
BTD
 Probe Info  		C788(1.07)  LDD2089  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C788(1.07)  LDD2089  [2]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C278(0.92); C615(0.47)  LDD2120  [2]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C788(1.37)  LDD2148  [2]

References

1 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761