Details of the Target
General Information of Target
| Target ID | LDTP09496 | |||||
|---|---|---|---|---|---|---|
| Target Name | Glucose-6-phosphate exchanger SLC37A2 (SLC37A2) | |||||
| Gene Name | SLC37A2 | |||||
| Gene ID | 219855 | |||||
| Synonyms |
Glucose-6-phosphate exchanger SLC37A2; Solute carrier family 37 member 2 |
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| 3D Structure | ||||||
| Sequence |
MRSSLAPGVWFFRAFSRDSWFRGLILLLTFLIYACYHMSRKPISIVKSRLHQNCSEQIKP
INDTHSLNDTMWCSWAPFDKDNYKELLGGVDNAFLIAYAIGMFISGVFGERLPLRYYLSA GMLLSGLFTSLFGLGYFWNIHELWYFVVIQVCNGLVQTTGWPSVVTCVGNWFGKGKRGFI MGIWNSHTSVGNILGSLIAGIWVNGQWGLSFIVPGIITAVMGVITFLFLIEHPEDVDCAP PQHHGEPAENQDNPEDPGNSPCSIRESGLETVAKCSKGPCEEPAAISFFGALRIPGVVEF SLCLLFAKLVSYTFLYWLPLYIANVAHFSAKEAGDLSTLFDVGGIIGGIVAGLVSDYTNG RATTCCVMLILAAPMMFLYNYIGQDGIASSIVMLIICGGLVNGPYALITTAVSADLGTHK SLKGNAKALSTVTAIIDGTGSIGAALGPLLAGLISPTGWNNVFYMLISADVLACLLLCRL VYKEILAWKVSLSRGSGYKEI |
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| Target Bioclass |
Transporter and channel
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| Family |
Major facilitator superfamily, Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family
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| Subcellular location |
Endoplasmic reticulum membrane
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| Function |
Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
STPyne Probe Info |
 |
K423(7.80) | LDD0277 | [1] | |
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ONAyne Probe Info |
 |
K274(9.09) | LDD0275 | [1] | |
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AHL-Pu-1 Probe Info |
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C280(2.21) | LDD0171 | [2] | |
Competitor(s) Related to This Target
References