Details of the Target

General Information of Target

Target ID LDTP09402
Target Name Rhophilin-1 (RHPN1)
Gene Name RHPN1
Gene ID 114822
Synonyms
KIAA1929; Rhophilin-1; GTP-Rho-binding protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MILEERPDGAGAGEESPRLQGCDSLTQIQCGQLQSRRAQIHQQIDKELQMRTGAENLYRA
TSNNRVRETVALELSYVNSNLQLLKEELEELSGGVDPGRHGSEAVTVPMIPLGLKETKEL
DWSTPLKELISVHFGEDGASYEAEIRELEALRQAMRTPSRNESGLELLTAYYNQLCFLDA
RFLTPARSLGLFFHWYDSLTGVPAQQRALAFEKGSVLFNIGALHTQIGARQDRSCTEGAR
RAMEAFQRAAGAFSLLRENFSHAPSPDMSAASLCALEQLMMAQAQECVFEGLSPPASMAP
QDCLAQLRLAQEAAQVAAEYRLVHRTMAQPPVHDYVPVSWTALVHVKAEYFRSLAHYHVA
MALCDGSPATEGELPTHEQVFLQPPTSSKPRGPVLPQELEERRQLGKAHLKRAILGQEEA
LRLHALCRVLREVDLLRAVISQTLQRSLAKYAELDREDDFCEAAEAPDIQPKTHQKPEAR
MPRLSQGKGPDIFHRLGPLSVFSAKNRWRLVGPVHLTRGEGGFGLTLRGDSPVLIAAVIP
GSQAAAAGLKEGDYIVSVNGQPCRWWRHAEVVTELKAAGEAGASLQVVSLLPSSRLPSLG
DRRPVLLGPRGLLRSQREHGCKTPASTWASPRPLLNWSRKAQQGKTGGCPQPCAPVKPAP
PSSLKHPGWP
Target Bioclass
Other
Family
RHPN family
Function Has no enzymatic activity. May serve as a target for Rho, and interact with some cytoskeletal component upon Rho binding or relay a Rho signal to other molecules.
Uniprot ID
Q8TCX5
Ensemble ID
ENST00000289013.11
HGNC ID
HGNC:19973

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C22(0.88); C30(0.88)  LDD0078  [1]
NAIA_5
 Probe Info  		C235(0.00); C461(0.00)  LDD2224  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0216  AC100 PaTu 8988t C22(0.91); C30(0.91)  LDD1095  [1]
 LDCM0217  AC101 PaTu 8988t C22(1.03); C30(1.03)  LDD1096  [1]
 LDCM0218  AC102 PaTu 8988t C22(1.15); C30(1.15)  LDD1097  [1]
 LDCM0219  AC103 PaTu 8988t C22(1.46); C30(1.46)  LDD1098  [1]
 LDCM0220  AC104 PaTu 8988t C22(0.84); C30(0.84)  LDD1099  [1]
 LDCM0221  AC105 PaTu 8988t C22(0.83); C30(0.83)  LDD1100  [1]
 LDCM0222  AC106 PaTu 8988t C22(1.20); C30(1.20)  LDD1101  [1]
 LDCM0223  AC107 PaTu 8988t C22(0.97); C30(0.97)  LDD1102  [1]
 LDCM0224  AC108 PaTu 8988t C22(1.23); C30(1.23)  LDD1103  [1]
 LDCM0225  AC109 PaTu 8988t C22(1.61); C30(1.61)  LDD1104  [1]
 LDCM0227  AC110 PaTu 8988t C22(1.28); C30(1.28)  LDD1106  [1]
 LDCM0228  AC111 PaTu 8988t C22(1.55); C30(1.55)  LDD1107  [1]
 LDCM0229  AC112 PaTu 8988t C22(1.16); C30(1.16)  LDD1108  [1]
 LDCM0230  AC113 PaTu 8988t C22(0.80); C30(0.80)  LDD1109  [1]
 LDCM0231  AC114 PaTu 8988t C22(1.02); C30(1.02)  LDD1110  [1]
 LDCM0232  AC115 PaTu 8988t C22(0.74); C30(0.74)  LDD1111  [1]
 LDCM0233  AC116 PaTu 8988t C22(0.97); C30(0.97)  LDD1112  [1]
 LDCM0234  AC117 PaTu 8988t C22(0.91); C30(0.91)  LDD1113  [1]
 LDCM0235  AC118 PaTu 8988t C22(0.92); C30(0.92)  LDD1114  [1]
 LDCM0236  AC119 PaTu 8988t C22(1.00); C30(1.00)  LDD1115  [1]
 LDCM0238  AC120 PaTu 8988t C22(1.13); C30(1.13)  LDD1117  [1]
 LDCM0239  AC121 PaTu 8988t C22(1.16); C30(1.16)  LDD1118  [1]
 LDCM0240  AC122 PaTu 8988t C22(0.86); C30(0.86)  LDD1119  [1]
 LDCM0241  AC123 PaTu 8988t C22(0.84); C30(0.84)  LDD1120  [1]
 LDCM0242  AC124 PaTu 8988t C22(1.28); C30(1.28)  LDD1121  [1]
 LDCM0243  AC125 PaTu 8988t C22(0.93); C30(0.93)  LDD1122  [1]
 LDCM0244  AC126 PaTu 8988t C22(0.72); C30(0.72)  LDD1123  [1]
 LDCM0245  AC127 PaTu 8988t C22(1.34); C30(1.34)  LDD1124  [1]
 LDCM0276  AC17 PaTu 8988t C22(1.16); C30(1.16)  LDD1155  [1]
 LDCM0277  AC18 PaTu 8988t C22(1.27); C30(1.27)  LDD1156  [1]
 LDCM0278  AC19 PaTu 8988t C22(0.92); C30(0.92)  LDD1157  [1]
 LDCM0280  AC20 PaTu 8988t C22(1.13); C30(1.13)  LDD1159  [1]
 LDCM0281  AC21 PaTu 8988t C22(0.84); C30(0.84)  LDD1160  [1]
 LDCM0282  AC22 PaTu 8988t C22(0.90); C30(0.90)  LDD1161  [1]
 LDCM0283  AC23 PaTu 8988t C22(1.19); C30(1.19)  LDD1162  [1]
 LDCM0284  AC24 PaTu 8988t C22(1.33); C30(1.33)  LDD1163  [1]
 LDCM0332  AC68 PaTu 8988t C22(0.85); C30(0.85)  LDD1211  [1]
 LDCM0333  AC69 PaTu 8988t C22(1.12); C30(1.12)  LDD1212  [1]
 LDCM0335  AC70 PaTu 8988t C22(0.73); C30(0.73)  LDD1214  [1]
 LDCM0336  AC71 PaTu 8988t C22(0.82); C30(0.82)  LDD1215  [1]
 LDCM0337  AC72 PaTu 8988t C22(0.73); C30(0.73)  LDD1216  [1]
 LDCM0338  AC73 PaTu 8988t C22(0.92); C30(0.92)  LDD1217  [1]
 LDCM0339  AC74 PaTu 8988t C22(0.94); C30(0.94)  LDD1218  [1]
 LDCM0340  AC75 PaTu 8988t C22(1.14); C30(1.14)  LDD1219  [1]
 LDCM0341  AC76 PaTu 8988t C22(0.91); C30(0.91)  LDD1220  [1]
 LDCM0342  AC77 PaTu 8988t C22(0.82); C30(0.82)  LDD1221  [1]
 LDCM0343  AC78 PaTu 8988t C22(0.90); C30(0.90)  LDD1222  [1]
 LDCM0344  AC79 PaTu 8988t C22(0.73); C30(0.73)  LDD1223  [1]
 LDCM0346  AC80 PaTu 8988t C22(0.80); C30(0.80)  LDD1225  [1]
 LDCM0347  AC81 PaTu 8988t C22(1.00); C30(1.00)  LDD1226  [1]
 LDCM0348  AC82 PaTu 8988t C22(1.03); C30(1.03)  LDD1227  [1]
 LDCM0349  AC83 PaTu 8988t C22(0.87); C30(0.87)  LDD1228  [1]
 LDCM0350  AC84 PaTu 8988t C22(0.90); C30(0.90)  LDD1229  [1]
 LDCM0351  AC85 PaTu 8988t C22(1.02); C30(1.02)  LDD1230  [1]
 LDCM0352  AC86 PaTu 8988t C22(0.93); C30(0.93)  LDD1231  [1]
 LDCM0353  AC87 PaTu 8988t C22(0.89); C30(0.89)  LDD1232  [1]
 LDCM0354  AC88 PaTu 8988t C22(0.94); C30(0.94)  LDD1233  [1]
 LDCM0355  AC89 PaTu 8988t C22(1.00); C30(1.00)  LDD1234  [1]
 LDCM0357  AC90 PaTu 8988t C22(0.82); C30(0.82)  LDD1236  [1]
 LDCM0358  AC91 PaTu 8988t C22(0.82); C30(0.82)  LDD1237  [1]
 LDCM0359  AC92 PaTu 8988t C22(0.86); C30(0.86)  LDD1238  [1]
 LDCM0360  AC93 PaTu 8988t C22(0.73); C30(0.73)  LDD1239  [1]
 LDCM0361  AC94 PaTu 8988t C22(0.90); C30(0.90)  LDD1240  [1]
 LDCM0362  AC95 PaTu 8988t C22(0.89); C30(0.89)  LDD1241  [1]
 LDCM0363  AC96 PaTu 8988t C22(0.72); C30(0.72)  LDD1242  [1]
 LDCM0364  AC97 PaTu 8988t C22(0.92); C30(0.92)  LDD1243  [1]
 LDCM0365  AC98 PaTu 8988t C22(1.11); C30(1.11)  LDD1244  [1]
 LDCM0366  AC99 PaTu 8988t C22(1.05); C30(1.05)  LDD1245  [1]
 LDCM0020  ARS-1620 HCC44 C22(0.88); C30(0.88)  LDD0078  [1]
 LDCM0374  CL105 PaTu 8988t C22(1.09); C30(1.09)  LDD1253  [1]
 LDCM0375  CL106 PaTu 8988t C22(1.35); C30(1.35)  LDD1254  [1]
 LDCM0376  CL107 PaTu 8988t C22(0.85); C30(0.85)  LDD1255  [1]
 LDCM0377  CL108 PaTu 8988t C22(1.39); C30(1.39)  LDD1256  [1]
 LDCM0378  CL109 PaTu 8988t C22(1.34); C30(1.34)  LDD1257  [1]
 LDCM0380  CL110 PaTu 8988t C22(2.11); C30(2.11)  LDD1259  [1]
 LDCM0381  CL111 PaTu 8988t C22(1.57); C30(1.57)  LDD1260  [1]
 LDCM0453  CL61 PaTu 8988t C22(1.17); C30(1.17)  LDD1332  [1]
 LDCM0454  CL62 PaTu 8988t C22(0.87); C30(0.87)  LDD1333  [1]
 LDCM0455  CL63 PaTu 8988t C22(0.91); C30(0.91)  LDD1334  [1]
 LDCM0456  CL64 PaTu 8988t C22(1.31); C30(1.31)  LDD1335  [1]
 LDCM0457  CL65 PaTu 8988t C22(1.10); C30(1.10)  LDD1336  [1]
 LDCM0458  CL66 PaTu 8988t C22(0.91); C30(0.91)  LDD1337  [1]
 LDCM0459  CL67 PaTu 8988t C22(1.25); C30(1.25)  LDD1338  [1]
 LDCM0460  CL68 PaTu 8988t C22(2.30); C30(2.30)  LDD1339  [1]
 LDCM0461  CL69 PaTu 8988t C22(1.89); C30(1.89)  LDD1340  [1]
 LDCM0463  CL70 PaTu 8988t C22(1.24); C30(1.24)  LDD1342  [1]
 LDCM0464  CL71 PaTu 8988t C22(1.24); C30(1.24)  LDD1343  [1]
 LDCM0465  CL72 PaTu 8988t C22(0.72); C30(0.72)  LDD1344  [1]
 LDCM0466  CL73 PaTu 8988t C22(2.11); C30(2.11)  LDD1345  [1]
 LDCM0467  CL74 PaTu 8988t C22(1.38); C30(1.38)  LDD1346  [1]
 LDCM0468  Fragment33 PaTu 8988t C22(1.21); C30(1.21)  LDD1347  [1]
 LDCM0021  THZ1 HCT 116 C22(0.84); C30(0.84)  LDD2173  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Peroxisomal ATPase PEX1 (PEX1) AAA ATPase family O43933
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Leucine zipper putative tumor suppressor 1 (LZTS1) LZTS family Q9Y250
Wolframin (WFS1) . O76024
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
G-protein coupled receptor-associated sorting protein 2 (GPRASP2) GPRASP family Q96D09
Other
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Progranulin (GRN) Granulin family P28799
Glial fibrillary acidic protein (GFAP) Intermediate filament family P14136
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Neurofilament light polypeptide (NEFL) Intermediate filament family P07196
Prelamin-A/C (LMNA) Intermediate filament family P02545
Microtubule-associated tumor suppressor candidate 2 (MTUS2) MTUS1 family Q5JR59
Centrosomal protein of 70 kDa (CEP70) . Q8NHQ1
Huntingtin-associated protein 1 (HAP1) . P54257
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264