Details of the Target

General Information of Target

Target ID LDTP09307
Target Name LIM domain only protein 3 (LMO3)
Gene Name LMO3
Gene ID 55885
Synonyms
RBTN3; RBTNL2; RHOM3; LIM domain only protein 3; LMO-3; Neuronal-specific transcription factor DAT1; Rhombotin-3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLSVQPDTKPKGCAGCNRKIKDRYLLKALDKYWHEDCLKCACCDCRLGEVGSTLYTKANL
ILCRRDYLRLFGVTGNCAACSKLIPAFEMVMRAKDNVYHLDCFACQLCNQRFCVGDKFFL
KNNMILCQTDYEEGLMKEGYAPQVR
Target Bioclass
Other
Uniprot ID
Q8TAP4
Ensemble ID
ENST00000261169.10
HGNC ID
HGNC:6643

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C81(1.01)  LDD3358  [1]
IA-alkyne
 Probe Info  		C113(0.76)  LDD2182  [2]
N1
 Probe Info  		M89(0.00); M91(0.00)  LDD0245  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0625  F8 Ramos C113(1.22)  LDD2187  [2]
 LDCM0572  Fragment10 Ramos C113(0.58)  LDD2189  [2]
 LDCM0574  Fragment12 Ramos C113(0.50)  LDD2191  [2]
 LDCM0576  Fragment14 Ramos C113(0.53)  LDD2193  [2]
 LDCM0579  Fragment20 Ramos C113(0.53)  LDD2194  [2]
 LDCM0580  Fragment21 Ramos C113(0.68)  LDD2195  [2]
 LDCM0582  Fragment23 Ramos C113(0.73)  LDD2196  [2]
 LDCM0578  Fragment27 Ramos C113(1.18)  LDD2197  [2]
 LDCM0586  Fragment28 Ramos C113(0.81)  LDD2198  [2]
 LDCM0588  Fragment30 Ramos C113(0.68)  LDD2199  [2]
 LDCM0589  Fragment31 Ramos C113(0.78)  LDD2200  [2]
 LDCM0590  Fragment32 Ramos C113(0.56)  LDD2201  [2]
 LDCM0468  Fragment33 Ramos C113(0.40)  LDD2202  [2]
 LDCM0596  Fragment38 Ramos C113(0.64)  LDD2203  [2]
 LDCM0566  Fragment4 Ramos C113(0.70)  LDD2184  [2]
 LDCM0610  Fragment52 Ramos C113(0.60)  LDD2204  [2]
 LDCM0614  Fragment56 Ramos C113(0.69)  LDD2205  [2]
 LDCM0569  Fragment7 Ramos C113(0.90)  LDD2186  [2]
 LDCM0571  Fragment9 Ramos C113(0.34)  LDD2188  [2]
 LDCM0022  KB02 Ramos C113(0.76)  LDD2182  [2]
 LDCM0023  KB03 Ramos C113(0.81)  LDD2183  [2]
 LDCM0024  KB05 NCI-H2291 C81(1.01)  LDD3358  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 29 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
5-hydroxymethyl-dUMP N-hydrolase (DNPH1) 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 family O43598
Replication factor C subunit 5 (RFC5) Activator 1 small subunits family P40937
Bile acid-CoA:amino acid N-acyltransferase (BAAT) C/M/P thioester hydrolase family Q14032
Pantetheine hydrolase VNN2 (VNN2) BTD/VNN family O95498
Thiopurine S-methyltransferase (TPMT) TPMT family P51580
NADH dehydrogenase flavoprotein 1, mitochondrial (NDUFV1) Complex I 51 kDa subunit family P49821
NADH dehydrogenase 1 alpha subcomplex subunit 5 (NDUFA5) Complex I NDUFA5 subunit family Q16718
DNA polymerase iota (POLI) DNA polymerase type-Y family Q9UNA4
NIF3-like protein 1 (NIF3L1) GTP cyclohydrolase I type 2/NIF3 family Q9GZT8
Lipoyl amidotransferase LIPT1, mitochondrial (LIPT1) LplA family Q9Y234
Thiol S-methyltransferase TMT1A (TMT1A) Methyltransferase superfamily Q9H8H3
NADPH-dependent diflavin oxidoreductase 1 (NDOR1) NADPH-dependent diflavin oxidoreductase NDOR1 family; Flavodoxin family; Flavoprotein pyridine nucleotide cytochrome reductase family Q9UHB4
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
Cathepsin O (CTSO) Peptidase C1 family P43234
Ubiquitin carboxyl-terminal hydrolase 38 (USP38) Peptidase C19 family Q8NB14
Ubiquitin thioesterase ZRANB1 (ZRANB1) Peptidase C64 family Q9UGI0
Carboxypeptidase N catalytic chain (CPN1) Peptidase M14 family P15169
E3 SUMO-protein ligase PIAS3 (PIAS3) PIAS family Q9Y6X2
Tribbles homolog 3 (TRIB3) CAMK Ser/Thr protein kinase family Q96RU7
Mitogen-activated protein kinase 11 (MAPK11) CMGC Ser/Thr protein kinase family Q15759
Mitogen-activated protein kinase kinase kinase 9 (MAP3K9) STE Ser/Thr protein kinase family P80192
E3 ubiquitin-protein ligase TRIM23 (TRIM23) Arf family P36406
Rho-related BTB domain-containing protein 1 (RHOBTB1) Rho family O94844
Acyl-coenzyme A thioesterase 13 (ACOT13) Thioesterase PaaI family Q9NPJ3
Septin-6 (SEPTIN6) Septin GTPase family Q14141
Tuftelin (TUFT1) Tuftelin family Q9NNX1
E3 ubiquitin-protein ligase RNF114 (RNF114) . Q9Y508
Tripartite motif-containing protein 54 (TRIM54) . Q9BYV2
Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase (PIP4P1) . Q86T03
Transporter and channel
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
PAT complex subunit CCDC47 (CCDC47) CCDC47 family Q96A33
Succinate dehydrogenase cytochrome b560 subunit, mitochondrial (SDHC) Cytochrome b560 family Q99643
Leucine zipper putative tumor suppressor 1 (LZTS1) LZTS family Q9Y250
Protein shisa-6 (SHISA6) Shisa family Q6ZSJ9
Sorting nexin-10 (SNX10) Sorting nexin family Q9Y5X0
Sorting nexin-33 (SNX33) Sorting nexin family Q8WV41
Vesicle-associated membrane protein 3 (VAMP3) Synaptobrevin family Q15836
Transmembrane protein 176B (TMEM176B) TMEM176 family Q3YBM2
AP-4 complex accessory subunit Tepsin (TEPSIN) . Q96N21
Calcium and integrin-binding protein 1 (CIB1) . Q99828
Stromal interaction molecule 1 (STIM1) . Q13586
Transcription factor
Click To Hide/Show 32 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-B13 (HOXB13) Abd-B homeobox family Q92826
Homeobox protein Hox-C4 (HOXC4) Antp homeobox family P09017
Transcription factor AP-2-beta (TFAP2B) AP-2 family Q92481
Zinc finger protein 143 (ZNF143) GLI C2H2-type zinc-finger protein family P52747
G-protein coupled receptor-associated sorting protein 2 (GPRASP2) GPRASP family Q96D09
DNA-binding protein Ikaros (IKZF1) Ikaros C2H2-type zinc-finger protein family Q13422
Zinc finger and BTB domain-containing protein 43 (ZBTB43) Krueppel C2H2-type zinc-finger protein family O43298
Zinc finger and SCAN domain-containing protein 9 (ZSCAN9) Krueppel C2H2-type zinc-finger protein family O15535
Zinc finger imprinted 3 (ZIM3) Krueppel C2H2-type zinc-finger protein family Q96PE6
Zinc finger protein 526 (ZNF526) Krueppel C2H2-type zinc-finger protein family Q8TF50
Zinc finger protein 587 (ZNF587) Krueppel C2H2-type zinc-finger protein family Q96SQ5
Zinc finger protein 620 (ZNF620) Krueppel C2H2-type zinc-finger protein family Q6ZNG0
Zinc finger protein 84 (ZNF84) Krueppel C2H2-type zinc-finger protein family P51523
Zinc finger protein with KRAB and SCAN domains 8 (ZKSCAN8) Krueppel C2H2-type zinc-finger protein family Q15776
NF-kappa-B inhibitor delta (NFKBID) NF-kappa-B inhibitor family Q8NI38
POU domain, class 6, transcription factor 2 (POU6F2) POU transcription factor family P78424
Krueppel-like factor 12 (KLF12) Sp1 C2H2-type zinc-finger protein family Q9Y4X4
Transcription factor Sp4 (SP4) Sp1 C2H2-type zinc-finger protein family Q02446
THAP domain-containing protein 1 (THAP1) THAP1 family Q9NVV9
Class E basic helix-loop-helix protein 40 (BHLHE40) . O14503
DNA-binding protein inhibitor ID-2 (ID2) . Q02363
Glucocorticoid modulatory element-binding protein 2 (GMEB2) . Q9UKD1
Golgin-45 (BLZF1) . Q9H2G9
Homeobox-containing protein 1 (HMBOX1) . Q6NT76
LIM/homeobox protein Lhx5 (LHX5) . Q9H2C1
Myeloid cell nuclear differentiation antigen (MNDA) . P41218
Myogenin (MYOG) . P15173
Transcription factor 4 (TCF4) . P15884
Transcription factor SOX-10 (SOX10) . P56693
Transcriptional regulator QRICH1 (QRICH1) . Q2TAL8
Zinc finger and BTB domain-containing protein 8B (ZBTB8B) . Q8NAP8
Zinc finger MYM-type protein 3 (ZMYM3) . Q14202
GPCR
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
D(1A) dopamine receptor (DRD1) G-protein coupled receptor 1 family P21728
Probable G-protein coupled receptor 160 (GPR160) G-protein coupled receptor 1 family Q9UJ42
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amphoterin-induced protein 1 (AMIGO1) AMIGO family Q86WK6
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Interleukin-3 receptor subunit alpha (IL3RA) Type I cytokine receptor family P26951
Other
Click To Hide/Show 75 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Angiomotin-like protein 2 (AMOTL2) Angiomotin family Q9Y2J4
Ankyrin repeat and SOCS box protein 1 (ASB1) Ankyrin SOCS box (ASB) family Q9Y576
Apoptosis-stimulating of p53 protein 1 (PPP1R13B) ASPP family Q96KQ4
B melanoma antigen 1 (BAGE) BAGE family Q13072
Protein BANP (BANP) BANP/SMAR1 family Q8N9N5
Coiled-coil domain-containing protein 90B, mitochondrial (CCDC90B) CCDC90 family Q9GZT6
Centrosomal protein of 76 kDa (CEP76) CEP76 family Q8TAP6
Protein chibby homolog 2 (CBY2) Chibby family Q8NA61
Reticulocalbin-1 (RCN1) CREC family Q15293
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Dexamethasone-induced protein (DEXI) DEXI family O95424
Eukaryotic translation initiation factor 3 subunit E (EIF3E) EIF-3 subunit E family P60228
Protein pelota homolog (PELO) Eukaryotic release factor 1 family Q9BRX2
Large ribosomal subunit protein eL33 (RPL35A) Eukaryotic ribosomal protein eL33 family P18077
Protein FAM131C (FAM131C) FAM131 family Q96AQ9
Fascin-2 (FSCN2) Fascin family O14926
Guanine nucleotide-binding protein subunit alpha-14 (GNA14) G-alpha family O95837
Centromere protein V (CENPV) Gfa family Q7Z7K6
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Golgin subfamily A member 6-like protein 9 (GOLGA6L9) GOLGA6 family A6NEM1
HCLS1-associated protein X-1 (HAX1) HAX1 family O00165
Histone H4 (H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16) Histone H4 family P62805
Immunoglobulin-binding protein 1 (IGBP1) IGBP1/TAP42 family P78318
Protein INCA1 (INCA1) INCA family Q0VD86
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cuticular Ha8 (KRT38) Intermediate filament family O76015
Mitochondrial assembly of ribosomal large subunit protein 1 (MALSU1) Iojap/RsfS family Q96EH3
Keratin-associated protein 3-1 (KRTAP3-1) KRTAP type 3 family Q9BYR8
LIM domain-binding protein 2 (LDB2) LDB family O43679
Leucine zipper putative tumor suppressor 2 (LZTS2) LZTS2 family Q9BRK4
Mitotic spindle assembly checkpoint protein MAD1 (MAD1L1) MAD1 family Q9Y6D9
Methyl-CpG-binding domain protein 3-like 1 (MBD3L1) MBD3L family Q8WWY6
MICOS complex subunit MIC19 (CHCHD3) MICOS complex subunit Mic19 family Q9NX63
Myozenin-3 (MYOZ3) Myozenin family Q8TDC0
NUT family member 1 (NUTM1) NUT family Q86Y26
Leupaxin (LPXN) Paxillin family O60711
Paraneoplastic antigen Ma1 (PNMA1) PNMA family Q8ND90
Prefoldin subunit 3 (VBP1) Prefoldin subunit alpha family P61758
SLAIN motif-containing protein 1 (SLAIN1) SLAIN motif-containing family Q8ND83
Heat shock protein beta-2 (HSPB2) Small heat shock protein (HSP20) family Q16082
Lumican (LUM) Small leucine-rich proteoglycan (SLRP) family P51884
SNW domain-containing protein 1 (SNW1) SNW family Q13573
Pre-mRNA-splicing factor SPF27 (BCAS2) SPF27 family O75934
Synaptogyrin-3 (SYNGR3) Synaptogyrin family O43761
T-complex protein 10A homolog 1 (TCP10L) TCP10 family Q8TDR4
Transmembrane protein 121 (TMEM121) TMEM121 family Q9BTD3
Transmembrane protein 54 (TMEM54) TMEM54 family Q969K7
Translin-associated protein X (TSNAX) Translin family Q99598
tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 (TRMT6) TRM6/GCD10 family Q9UJA5
Macrophage immunometabolism regulator (MACIR) UNC119-binding protein family Q96GV9
UPF0547 protein C16orf87 (C16orf87) UPF0547 family Q6PH81
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 (ACAP1) . Q15027
Arginine vasopressin-induced protein 1 (AVPI1) . Q5T686
BEN domain-containing protein 5 (BEND5) . Q7L4P6
BTB/POZ domain-containing protein KCTD1 (KCTD1) . Q719H9
BTB/POZ domain-containing protein KCTD17 (KCTD17) . Q8N5Z5
Chromodomain Y-like protein 2 (CDYL2) . Q8N8U2
Doublecortin domain-containing protein 2 (DCDC2) . Q9UHG0
Filamin-binding LIM protein 1 (FBLIM1) . Q8WUP2
Heterogeneous nuclear ribonucleoprotein F (HNRNPF) . P52597
Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) . P31943
Insulin-like growth factor-binding protein 3 (IGFBP3) . P17936
KN motif and ankyrin repeat domain-containing protein 2 (KANK2) . Q63ZY3
Melanoma-associated antigen H1 (MAGEH1) . Q9H213
PRKCA-binding protein (PICK1) . Q9NRD5
Programmed cell death protein 2 (PDCD2) . Q16342
RCC1-like G exchanging factor-like protein (RCC1L) . Q96I51
Regulating synaptic membrane exocytosis protein 3 (RIMS3) . Q9UJD0
Rho guanine nucleotide exchange factor 9 (ARHGEF9) . O43307
Sterile alpha motif domain-containing protein 3 (SAMD3) . Q8N6K7
Tax1-binding protein 1 (TAX1BP1) . Q86VP1
Vimentin-type intermediate filament-associated coiled-coil protein (VMAC) . Q2NL98
Vitamin K-dependent protein S (PROS1) . P07225
Zinc finger FYVE domain-containing protein 21 (ZFYVE21) . Q9BQ24
Zinc finger protein 346 (ZNF346) . Q9UL40

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.