Details of the Target

General Information of Target

Target ID LDTP09289
Target Name Protocadherin-19 (PCDH19)
Gene Name PCDH19
Gene ID 57526
Synonyms
KIAA1313; Protocadherin-19
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MESLLLPVLLLLAILWTQAAALINLKYSVEEEQRAGTVIANVAKDAREAGFALDPRQASA
FRVVSNSAPHLVDINPSSGLLVTKQKIDRDLLCRQSPKCIISLEVMSSSMEICVIKVEIK
DLNDNAPSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTPNELFGLEIKT
RGDGSRFAELVVEKSLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTDSNDNNPVFSE
STYAVSVPENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSGLVTV
TGALDYEEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPVINLLSVNSELVEVSE
SAPPGYVIALVRVSDRDSGLNGRVQCRLLGNVPFRLQEYESFSTILVDGRLDREQHDQYN
LTIQARDGGVPMLQSAKSFTVLITDENDNHPHFSKPYYQVIVQENNTPGAYLLSVSARDP
DLGLNGSVSYQIVPSQVRDMPVFTYVSINPNSGDIYALRSFNHEQTKAFEFKVLAKDGGL
PSLQSNATVRVIILDVNDNTPVITAPPLINGTAEVYIPRNSGIGYLVTVVKAEDYDEGEN
GRVTYDMTEGDRGFFEIDQVNGEVRTTRTFGESSKSSYELIVVAHDHGKTSLSASALVLI
YLSPALDAQESMGSVNLSLIFIIALGSIAGILFVTMIFVAIKCKRDNKEIRTYNCSNCLT
ITCLLGCFIKGQNSKCLHCISVSPISEEQDKKTEEKVSLRGKRIAEYSYGHQKKSSKKKK
ISKNDIRLVPRDVEETDKMNVVSCSSLTSSLNYFDYHQQTLPLGCRRSESTFLNVENQNT
RNTSANHIYHHSFNSQGPQQPDLIINGVPLPETENYSFDSNYVNSRAHLIKSSSTFKDLE
GNSLKDSGHEESDQTDSEHDVQRSLYCDTAVNDVLNTSVTSMGSQMPDHDQNEGFHCREE
CRILGHSDRCWMPRNPMPIRSKSPEHVRNIIALSIEATAADVEAYDDCGPTKRTFATFGK
DVSDHPAEERPTLKGKRTVDVTICSPKVNSVIREAGNGCEAISPVTSPLHLKSSLPTKPS
VSYTIALAPPARDLEQYVNNVNNGPTRPSEAEPRGADSEKVMHEVSPILKEGRNKESPGV
KRLKDIVL
Target Bioclass
Other
Subcellular location
Cell membrane
Function Calcium-dependent cell-adhesion protein.
Uniprot ID
Q8TAB3
Ensemble ID
ENST00000255531.8
HGNC ID
HGNC:14270

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA Deletion: p.P364RfsTer4 .
CCK81 Deletion: p.P364RfsTer4 .
COLO792 SNV: p.G954R; p.W971Ter .
DU145 SNV: p.P393A; p.Q860H .
HCC1143 SNV: p.D596V .
HCC15 SNV: p.W971C .
HCT15 SNV: p.A517V .
HT115 SNV: p.I764L .
Ishikawa (Heraklio) 02 ER Deletion: p.P364RfsTer4 .
J82 SNV: p.R579H .
KMCH1 SNV: p.N171K .
LS180 SNV: p.A21T .
MCC13 SNV: p.R47Q .
MCC26 SNV: p.H956Y .
NCIH1155 SNV: p.R383C .
NCIH1703 SNV: p.E1028D .
NCIH446 SNV: p.H851Q .
OVK18 SNV: p.V29I; p.R56Q .
RKO Deletion: p.P364RfsTer4 .
RL952 SNV: p.A46V .
RPMI8226 SNV: p.G867A .
SKMEL28 SNV: p.Y661Ter .
SKOV3 SNV: p.W16R .
SUPT1 SNV: p.R89H .
TOV21G Deletion: p.P364RfsTer4 .
WM2664 Insertion: p.E530RfsTer41 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C997(1.63)  LDD3310  [1]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C330(0.91)  LDD1507  [3]
 LDCM0215  AC10 HEK-293T C1044(0.85)  LDD1508  [3]
 LDCM0276  AC17 HEK-293T C330(0.96)  LDD1515  [3]
 LDCM0277  AC18 HEK-293T C1044(0.77)  LDD1516  [3]
 LDCM0279  AC2 HEK-293T C1044(0.91)  LDD1518  [3]
 LDCM0285  AC25 HEK-293T C330(0.96)  LDD1524  [3]
 LDCM0286  AC26 HEK-293T C1044(1.05)  LDD1525  [3]
 LDCM0294  AC33 HEK-293T C330(1.12)  LDD1533  [3]
 LDCM0295  AC34 HEK-293T C1044(1.13)  LDD1534  [3]
 LDCM0303  AC41 HEK-293T C330(1.00)  LDD1542  [3]
 LDCM0304  AC42 HEK-293T C1044(1.04)  LDD1543  [3]
 LDCM0311  AC49 HEK-293T C330(0.92)  LDD1550  [3]
 LDCM0313  AC50 HEK-293T C1044(0.74)  LDD1552  [3]
 LDCM0320  AC57 HEK-293T C330(0.93)  LDD1559  [3]
 LDCM0321  AC58 HEK-293T C1044(0.97)  LDD1560  [3]
 LDCM0356  AKOS034007680 HEK-293T C330(1.11)  LDD1570  [3]
 LDCM0369  CL100 HEK-293T C825(0.84)  LDD1573  [3]
 LDCM0373  CL104 HEK-293T C825(1.11)  LDD1577  [3]
 LDCM0377  CL108 HEK-293T C825(1.02)  LDD1581  [3]
 LDCM0382  CL112 HEK-293T C825(0.77)  LDD1586  [3]
 LDCM0386  CL116 HEK-293T C825(0.79)  LDD1590  [3]
 LDCM0391  CL120 HEK-293T C825(0.85)  LDD1595  [3]
 LDCM0395  CL124 HEK-293T C825(0.83)  LDD1599  [3]
 LDCM0399  CL128 HEK-293T C825(0.96)  LDD1603  [3]
 LDCM0403  CL16 HEK-293T C825(0.94)  LDD1607  [3]
 LDCM0404  CL17 HEK-293T C330(0.99)  LDD1608  [3]
 LDCM0405  CL18 HEK-293T C1044(0.78)  LDD1609  [3]
 LDCM0416  CL28 HEK-293T C825(0.83)  LDD1620  [3]
 LDCM0417  CL29 HEK-293T C330(1.07)  LDD1621  [3]
 LDCM0419  CL30 HEK-293T C1044(0.91)  LDD1623  [3]
 LDCM0429  CL4 HEK-293T C825(1.20)  LDD1633  [3]
 LDCM0430  CL40 HEK-293T C825(0.74)  LDD1634  [3]
 LDCM0431  CL41 HEK-293T C330(0.98)  LDD1635  [3]
 LDCM0432  CL42 HEK-293T C1044(0.69)  LDD1636  [3]
 LDCM0440  CL5 HEK-293T C330(0.98)  LDD1644  [3]
 LDCM0443  CL52 HEK-293T C825(0.86)  LDD1646  [3]
 LDCM0444  CL53 HEK-293T C330(0.94)  LDD1647  [3]
 LDCM0445  CL54 HEK-293T C1044(0.84)  LDD1648  [3]
 LDCM0451  CL6 HEK-293T C1044(0.77)  LDD1654  [3]
 LDCM0456  CL64 HEK-293T C825(1.37)  LDD1659  [3]
 LDCM0457  CL65 HEK-293T C330(1.01)  LDD1660  [3]
 LDCM0458  CL66 HEK-293T C1044(0.85)  LDD1661  [3]
 LDCM0469  CL76 HEK-293T C825(1.02)  LDD1672  [3]
 LDCM0470  CL77 HEK-293T C330(0.96)  LDD1673  [3]
 LDCM0471  CL78 HEK-293T C1044(0.87)  LDD1674  [3]
 LDCM0482  CL88 HEK-293T C825(1.12)  LDD1685  [3]
 LDCM0483  CL89 HEK-293T C330(0.99)  LDD1686  [3]
 LDCM0485  CL90 HEK-293T C1044(0.71)  LDD1688  [3]
 LDCM0022  KB02 CHL1 C997(1.60)  LDD2475  [1]
 LDCM0023  KB03 CHL1 C997(1.56)  LDD2892  [1]
 LDCM0024  KB05 COLO792 C997(1.63)  LDD3310  [1]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Calcium . DB01373

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402