Details of the Target

General Information of Target

Target ID LDTP09178
Target Name Exophilin-5 (EXPH5)
Gene Name EXPH5
Gene ID 23086
Synonyms
KIAA0624; SLAC2B; Exophilin-5; Synaptotagmin-like protein homolog lacking C2 domains b; SlaC2-b; Slp homolog lacking C2 domains b
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTKVPPAFDFSFLNDEEARKILQVLERNEELQRAEKDRISKLQKTKRDIRWLQGVTGEWF
EEIQRKKFCNETDVSQMLKQPLTYRLSKEMAKNDPIELPTSRSKNVTNQKKPTPFSSRMS
FRSSFASLFSFRKSGKETSKLPSLGQKGCDGHAGPPMPVRGAAVQAKIYNSPLENHLVDS
TFVPKPAVMREESGMPPPWDASLLENEFFQVLDDLDSKLAQEQSASSVNTRTPLNYGSRT
QFGHFYSSGNRHGNITERHKKHYNETSNMSIYDILRPGTPREGFKTFSPRTSTIYDMYRT
REPRVFKEDYVQKNTFGSTSLCFDSRQRSALPATGHFTARSLHFPATTQSKSGFIPPRHQ
QSPKRTPLSSIIWNRSDSSRDRENQEEFLRAPSPMEIDPADKYVYPRGFQENKRYESYHS
QNVYQRVSLNAPMENAMSPDTFENSENMPFYHQSNTFTRSFFSNTFGRSGEQRRFGQGPF
WGQEKGHSFWSDFHRSRKSFSSSDRDFEMISMEANSVSAIHGHNVSSEHWESFSSGYGTD
VSRGQEEPHPWQFDFQRSTLDSMVVSHGNETQLTPHFGTPNVCSMTGSSYHVKSSELVSQ
QDSSPVEVHINKEASSFGIAQTLASSFKTSFSQISDDRRNPQSPNLQNPTVTLQKIFPNK
PASHPMRSHTEVTVTSSNSVDSLPLAKSQPNILVTEVNNEKDLNESISEEDKQLSKMDQT
NKAGEIPQPVSQTGISNSLPDFQNPLSQDSAKSNGFGFNASTIISSKKSPRVFSRKDTSK
MYIPHTDKSNDIKQDKRFTENRKLGSTASLPFIQEHRTPPSFPRTDQGCHQELTVNNEDI
SRIITNNHWSSALTDTQNAQYSKCKLTPGHKTSCDSLDLSSAALPDSSPSKNSSLDAPVV
PSTTVFSRRSPSDKDPSLGEREEKDNAGKNQKNQFIVSHSENQERNDSPVPTHDEVVDVK
CHSHSPFRNERGKGKIRHHISCIEKLSKTESISVPTSDHRSLIEANQSNSKVSELDTIYC
TLPRKSSSFLIHGRQSGSKIMAASLRNGPPPFQIKNNVEDAMGNYMLNKFSPSSPESANE
CSKVLSDSALEAPEATERMTNVKSSGSTSVRKGPLPFLINRAMSCPSGEPHASTGREGRK
KPLTSGMDASELTPRAWERIISPVESDSSVRDCSLTKRQHQKENFQEYTEKEGKMAASRR
SVFALSNEDPLPFCSDLSGKERGKTLHKVKTTSTFSVSGDEDNVKCLEVVSIYYTLPRKP
SKKFCNLLQQYTQNTNLLIESPQVETETFPNALEKDKQNYSTREQSGTPSCENLKMSVNS
DQTLTTENMTAFRLSNRGPLAPTLQEMASVEAAVSLPEEESKAREIFSDNLAKTPLGDSE
NKKERGKKLQSETLHTSLMLQRKNVSEEKSENCQQSINSSNSGPSSLPALSEVNIGNSQT
RRSSWECTGSGRAIPFTGSGKCPQKDHTSTAVGDGSSGSQPREGRGDIGTNCQKMTNKTL
SHSESQVFALTPALHKLQLGEETQSDEPNLESLQSEPRELPQRSQEANMTESRKAEDEMQ
KSAWDQPSLPEGNKNKTNLDDLVKGENRSSVKHRLAAMSKASRKFPAKDVSPRRHVATIF
PQSGSRSGFDHLSLGTVECNPLFPEPTPKSAESIGESRLSENGKHVKKSENLLPITVLPN
REPSTHVSNQKSNSISQRHQNEFKNVSESPSKHENSKDVTAAQNLVRESGAPSPITFTSL
REAEFSDNQRRLSPPFPLEPAQKSRVSSPLASFLQQQRSASSLEWEPEPHLYRSKSLKSI
NVHGDLLRKSHPPKVRERHFSESTSIDNALSRLTLGNEFSVNNGYSRRFRSFSELPSCDG
NESWAYRSGTKTGPRSAISIYRPIDYGIFGKEQQLAFLENVKRSLTQGRLWKPSFLKNPG
FLKDDLRNPPNPSESLSSNSPSSQVPEDGLSPSEPLNIYEDDPVDSDCDTDTTTDDEYYL
DENDKESEL
Target Bioclass
Other
Function May act as Rab effector protein and play a role in vesicle trafficking.
Uniprot ID
Q8NEV8
Ensemble ID
ENST00000265843.9
HGNC ID
HGNC:30578

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
786O SNV: p.S501T .
AN3CA SNV: p.S1544N .
CALU6 SNV: p.T458S DBIA    Probe Info 
COLO679 Deletion: p.F461SfsTer49 .
COLO792 SNV: p.E1786K .
DAOY SNV: p.S376L .
HCT15 SNV: p.S320P .
HDQP1 SNV: p.S1124L; p.I1619M .
HEL SNV: p.Q1700R .
HEL9217 SNV: p.Q1700R .
HT115 SNV: p.E696K; p.S1349Y; p.D1805N; p.T1974P .
HUPT3 SNV: p.L1898S .
JURKAT SNV: p.H1032Y .
KYSE180 SNV: p.H419R .
NCIH358 SNV: p.G1113Ter .
NUGC3 SNV: p.H1515Y .
PEO1 SNV: p.G1338E .
SKMEL24 SNV: p.K687N .
SKMEL5 SNV: p.G1486E .
U2OS Deletion: p.K1409NfsTer64 .
YSCCC SNV: p.F1620L .
ZR751 SNV: p.S127F DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C149(2.24); C1492(2.31)  LDD3314  [1]
IPM
 Probe Info  		N.A.  LDD2156  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C1311(1.02)  LDD1508  [3]
 LDCM0270  AC15 HEK-293T C961(1.27)  LDD1513  [3]
 LDCM0277  AC18 HEK-293T C1311(0.93)  LDD1516  [3]
 LDCM0279  AC2 HEK-293T C1311(1.00)  LDD1518  [3]
 LDCM0283  AC23 HEK-293T C961(0.98)  LDD1522  [3]
 LDCM0286  AC26 HEK-293T C1311(0.99)  LDD1525  [3]
 LDCM0292  AC31 HEK-293T C961(1.07)  LDD1531  [3]
 LDCM0295  AC34 HEK-293T C1311(0.92)  LDD1534  [3]
 LDCM0300  AC39 HEK-293T C961(1.13)  LDD1539  [3]
 LDCM0304  AC42 HEK-293T C1311(1.18)  LDD1543  [3]
 LDCM0309  AC47 HEK-293T C961(1.38)  LDD1548  [3]
 LDCM0313  AC50 HEK-293T C1311(1.03)  LDD1552  [3]
 LDCM0318  AC55 HEK-293T C961(1.12)  LDD1557  [3]
 LDCM0321  AC58 HEK-293T C1311(1.02)  LDD1560  [3]
 LDCM0327  AC63 HEK-293T C961(0.97)  LDD1566  [3]
 LDCM0334  AC7 HEK-293T C961(1.21)  LDD1568  [3]
 LDCM0371  CL102 HEK-293T C1311(0.96)  LDD1575  [3]
 LDCM0375  CL106 HEK-293T C1311(0.90)  LDD1579  [3]
 LDCM0379  CL11 HEK-293T C961(1.20)  LDD1583  [3]
 LDCM0380  CL110 HEK-293T C1311(1.15)  LDD1584  [3]
 LDCM0384  CL114 HEK-293T C1311(0.91)  LDD1588  [3]
 LDCM0388  CL118 HEK-293T C1311(0.98)  LDD1592  [3]
 LDCM0393  CL122 HEK-293T C1311(0.98)  LDD1597  [3]
 LDCM0397  CL126 HEK-293T C1311(0.98)  LDD1601  [3]
 LDCM0401  CL14 HEK-293T C1311(0.99)  LDD1605  [3]
 LDCM0405  CL18 HEK-293T C1311(1.10)  LDD1609  [3]
 LDCM0407  CL2 HEK-293T C1311(0.97)  LDD1611  [3]
 LDCM0411  CL23 HEK-293T C961(1.24)  LDD1615  [3]
 LDCM0414  CL26 HEK-293T C1311(0.95)  LDD1618  [3]
 LDCM0419  CL30 HEK-293T C1311(1.18)  LDD1623  [3]
 LDCM0424  CL35 HEK-293T C961(1.16)  LDD1628  [3]
 LDCM0432  CL42 HEK-293T C1311(1.10)  LDD1636  [3]
 LDCM0437  CL47 HEK-293T C961(1.39)  LDD1641  [3]
 LDCM0441  CL50 HEK-293T C1311(0.92)  LDD1645  [3]
 LDCM0445  CL54 HEK-293T C1311(1.03)  LDD1648  [3]
 LDCM0450  CL59 HEK-293T C961(1.16)  LDD1653  [3]
 LDCM0451  CL6 HEK-293T C1311(1.05)  LDD1654  [3]
 LDCM0454  CL62 HEK-293T C1311(0.93)  LDD1657  [3]
 LDCM0458  CL66 HEK-293T C1311(1.06)  LDD1661  [3]
 LDCM0464  CL71 HEK-293T C961(1.40)  LDD1667  [3]
 LDCM0467  CL74 HEK-293T C1311(1.24)  LDD1670  [3]
 LDCM0471  CL78 HEK-293T C1311(1.05)  LDD1674  [3]
 LDCM0477  CL83 HEK-293T C961(1.12)  LDD1680  [3]
 LDCM0480  CL86 HEK-293T C1311(0.92)  LDD1683  [3]
 LDCM0485  CL90 HEK-293T C1311(0.94)  LDD1688  [3]
 LDCM0490  CL95 HEK-293T C961(1.12)  LDD1693  [3]
 LDCM0493  CL98 HEK-293T C1311(1.45)  LDD1696  [3]
 LDCM0427  Fragment51 HEK-293T C1311(0.85)  LDD1631  [3]
 LDCM0022  KB02 A2780 C149(1.51)  LDD2254  [1]
 LDCM0023  KB03 A2780 C149(1.40)  LDD2671  [1]
 LDCM0024  KB05 IGR37 C149(2.24); C1492(2.31)  LDD3314  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402