Details of the Target

General Information of Target

Target ID LDTP09157
Target Name Meiosis-specific nuclear structural protein 1 (MNS1)
Gene Name MNS1
Gene ID 55329
Synonyms
Meiosis-specific nuclear structural protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGSKRRNLSCSERHQKLVDENYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLL
QNEQFELDMEEAIQKAEENKRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSIE
LRELEKKLKAAYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKR
NKAKAQYYLDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKLEKMNA
MRRYIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQN
ALTQKLEEMLRQREDLEQVRQELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQMAL
KELVLQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEHRRAVEKLIEERRQQFL
ADKQRELEEWQLQQRRQGFINAIIEEERLKLLKEHATNLLGYLPKGVFKKEDDIDLLGEE
FRKVYQQRSEICEEK
Target Bioclass
Other
Family
MNS1 family
Subcellular location
Nucleus
Function
Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. May play a role in the control of meiotic division and germ cell differentiation through regulation of pairing and recombination during meiosis. Required for sperm flagella assembly. May play a role in the assembly and function of the outer dynein arm-docking complex (ODA-DC). ODA-DC mediates outer dynein arms (ODA) binding onto the axonemal doublet microtubules.
Uniprot ID
Q8NEH6
Ensemble ID
ENST00000260453.4
HGNC ID
HGNC:29636

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
CY4
 Probe Info  		N.A.  LDD0247  [1]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-2
 Probe Info  		N.A.  LDD0139  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
GTPase HRas (HRAS) Ras family P01112
Tripartite motif-containing protein 54 (TRIM54) . Q9BYV2
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sorting nexin-32 (SNX32) Sorting nexin family Q86XE0
THO complex subunit 7 homolog (THOC7) THOC7 family Q6I9Y2
Other
Click To Hide/Show 16 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein AATF (AATF) AATF family Q9NY61
Cerebellar degeneration-related protein 2 (CDR2) CDR2 family Q01850
G1/S-specific cyclin-D3 (CCND3) Cyclin family P30281
Radial spoke head 14 homolog (RSPH14) Flagellar radial spoke RSP14 family Q9UHP6
GRB10-interacting GYF protein 1 (GIGYF1) GIGYF family O75420
Keratin, type I cuticular Ha4 (KRT34) Intermediate filament family O76011
Keratin, type II cytoskeletal 75 (KRT75) Intermediate filament family O95678
Harmonin-binding protein USHBP1 (USHBP1) MCC family Q8N6Y0
Stathmin-3 (STMN3) Stathmin family Q9NZ72
Beta-taxilin (TXLNB) Taxilin family Q8N3L3
Troponin I, fast skeletal muscle (TNNI2) Troponin I family P48788
Troponin I, slow skeletal muscle (TNNI1) Troponin I family P19237
KN motif and ankyrin repeat domain-containing protein 2 (KANK2) . Q63ZY3
PRKCA-binding protein (PICK1) . Q9NRD5
Protein moonraker (KIAA0753) . Q2KHM9
Zinc finger MYND domain-containing protein 12 (ZMYND12) . Q9H0C1

References

1 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
2 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.