Details of the Target

General Information of Target

Target ID LDTP09111
Target Name Polypeptide N-acetylgalactosaminyltransferase 11 (GALNT11)
Gene Name GALNT11
Gene ID 63917
Synonyms
Polypeptide N-acetylgalactosaminyltransferase 11; EC 2.4.1.41; Polypeptide GalNAc transferase 11; GalNAc-T11; pp-GaNTase 11; Protein-UDP acetylgalactosaminyltransferase 11; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 11
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGSVTVRYFCYGCLFTSATWTVLLFVYFNFSEVTQPLKNVPVKGSGPHGPSPKKFYPRFT
RGPSRVLEPQFKANKIDDVIDSRVEDPEEGHLKFSSELGMIFNERDQELRDLGYQKHAFN
MLISDRLGYHRDVPDTRNAACKEKFYPPDLPAASVVICFYNEAFSALLRTVHSVIDRTPA
HLLHEIILVDDDSDFDDLKGELDEYVQKYLPGKIKVIRNTKREGLIRGRMIGAAHATGEV
LVFLDSHCEVNVMWLQPLLAAIREDRHTVVCPVIDIISADTLAYSSSPVVRGGFNWGLHF
KWDLVPLSELGRAEGATAPIKSPTMAGGLFAMNRQYFHELGQYDSGMDIWGGENLEISFR
IWMCGGKLFIIPCSRVGHIFRKRRPYGSPEGQDTMTHNSLRLAHVWLDEYKEQYFSLRPD
LKTKSYGNISERVELRKKLGCKSFKWYLDNVYPEMQISGSHAKPQQPIFVNRGPKRPKVL
QRGRLYHLQTNKCLVAQGRPSQKGGLVVLKACDYSDPNQIWIYNEEHELVLNSLLCLDMS
ETRSSDPPRLMKCHGSGGSQQWTFGKNNRLYQVSVGQCLRAVDPLGQKGSVAMAICDGSS
SQQWHLEG
Target Bioclass
Enzyme
Family
Glycosyltransferase 2 family, GalNAc-T subfamily
Subcellular location
Golgi apparatus membrane
Function
Polypeptide N-acetylgalactosaminyltransferase that catalyzes the initiation of protein O-linked glycosylation and is involved in left/right asymmetry by mediating O-glycosylation of NOTCH1. O-glycosylation of NOTCH1 promotes activation of NOTCH1, modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). Polypeptide N-acetylgalactosaminyltransferases catalyze the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays the same enzyme activity toward MUC1, MUC4, and EA2 than GALNT1. Not involved in glycosylation of erythropoietin (EPO).
Uniprot ID
Q8NCW6
Ensemble ID
ENST00000415421.5
HGNC ID
HGNC:19875

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AU565 SNV: p.D275H .
CMK SNV: p.R580T .
HCT15 SNV: p.P57A .
HEC1 SNV: p.Y414F .
LNCaP clone FGC SNV: p.S430T .
SKMEL2 SNV: p.E108K .
SNU1 Deletion: p.K438del .
SW1116 SNV: p.Q256E .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C578(4.52)  LDD3369  [1]
NAIA_5
 Probe Info  		N.A.  LDD2223  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0270  AC15 HEK-293T C373(1.15)  LDD1513  [3]
 LDCM0283  AC23 HEK-293T C373(1.06)  LDD1522  [3]
 LDCM0292  AC31 HEK-293T C373(1.04)  LDD1531  [3]
 LDCM0300  AC39 HEK-293T C373(1.12)  LDD1539  [3]
 LDCM0309  AC47 HEK-293T C373(1.06)  LDD1548  [3]
 LDCM0318  AC55 HEK-293T C373(1.10)  LDD1557  [3]
 LDCM0327  AC63 HEK-293T C373(1.17)  LDD1566  [3]
 LDCM0334  AC7 HEK-293T C373(1.19)  LDD1568  [3]
 LDCM0379  CL11 HEK-293T C373(1.23)  LDD1583  [3]
 LDCM0411  CL23 HEK-293T C373(1.12)  LDD1615  [3]
 LDCM0424  CL35 HEK-293T C373(1.13)  LDD1628  [3]
 LDCM0437  CL47 HEK-293T C373(1.27)  LDD1641  [3]
 LDCM0450  CL59 HEK-293T C373(1.14)  LDD1653  [3]
 LDCM0464  CL71 HEK-293T C373(1.02)  LDD1667  [3]
 LDCM0477  CL83 HEK-293T C373(1.20)  LDD1680  [3]
 LDCM0490  CL95 HEK-293T C373(1.08)  LDD1693  [3]
 LDCM0022  KB02 ICC108 C364(1.83)  LDD2381  [1]
 LDCM0023  KB03 ICC108 C364(2.47)  LDD2798  [1]
 LDCM0024  KB05 OAW-42 C578(4.52)  LDD3369  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402