Details of the Target

General Information of Target

Target ID LDTP09026
Target Name Ankyrin repeat and LEM domain-containing protein 1 (ANKLE1)
Gene Name ANKLE1
Gene ID 126549
Synonyms
ANKRD41; LEM3; Ankyrin repeat and LEM domain-containing protein 1; EC 3.1.-.-; Ankyrin repeat domain-containing protein 41; LEM-domain containing protein 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MCSEARLARRLRDALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLG
ALLRQGGDPNARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQG
HLECARVLQDLDTRTRTRTRIGAETQEPEPAPGTPGLSGPTDETLDSIALQKQPCRGDNR
DIGLEADPGPPSLPVPLETVDKHGSSASPPGHWDYSSDASFVTAVEVSGAEDPASDTPPW
AGSLPPTRQGLLHVVHANQRVPRSQGTEAELNARLQALTLTPPNAAGFQSSPSSMPLLDR
SPAHSPPRTPTPGASDCHCLWEHQTSIDSDMATLWLTEDEASSTGGREPVGPCRHLPVST
VSDLELLKGLRALGENPHPITPFTRQLYHQQLEEAQIAPGPEFSGHSLELAAALRTGCIP
DVQADEDALAQQFEQPDPARRWREGVVKSSFTYLLLDPRETQDLPARAFSLTPAERLQTF
IRAIFYVGKGTRARPYVHLWEALGHHGRSRKQPHQACPKVRQILDIWASGCGVVSLHCFQ
HVVAVEAYTREACIVEALGIQTLTNQKQGHCYGVVAGWPPARRRRLGVHLLHRALLVFLA
EGERQLHPQDIQARG
Target Bioclass
Enzyme
Subcellular location
Cytoplasm
Function Endonuclease that probably plays a role in the DNA damage response and DNA repair.
Uniprot ID
Q8NAG6
Ensemble ID
ENST00000404085.7
HGNC ID
HGNC:26812

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C517(2.51)  LDD3334  [1]
IA-alkyne
 Probe Info  		C88(1.40)  LDD2182  [2]
IPM
 Probe Info  		C58(1.34)  LDD1701  [3]
TFBX
 Probe Info  		N.A.  LDD0148  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0625  F8 Ramos C58(0.62); C517(2.34); C88(0.58)  LDD2187  [2]
 LDCM0573  Fragment11 Ramos C58(6.11); C517(0.92)  LDD2190  [2]
 LDCM0576  Fragment14 Ramos C58(0.57); C517(0.83); C88(0.95)  LDD2193  [2]
 LDCM0580  Fragment21 Ramos C58(0.74)  LDD2195  [2]
 LDCM0582  Fragment23 Ramos C58(1.00)  LDD2196  [2]
 LDCM0586  Fragment28 Ramos C58(0.96); C517(0.72); C88(3.78)  LDD2198  [2]
 LDCM0588  Fragment30 Ramos C58(1.52)  LDD2199  [2]
 LDCM0468  Fragment33 Ramos C58(0.75)  LDD2202  [2]
 LDCM0596  Fragment38 Ramos C58(0.65)  LDD2203  [2]
 LDCM0566  Fragment4 Ramos C517(0.85); C88(0.32)  LDD2184  [2]
 LDCM0614  Fragment56 Ramos C58(1.74)  LDD2205  [2]
 LDCM0569  Fragment7 Ramos C517(0.75); C88(0.58)  LDD2186  [2]
 LDCM0022  KB02 Ramos C88(1.40)  LDD2182  [2]
 LDCM0023  KB03 MDA-MB-231 C58(1.34)  LDD1701  [3]
 LDCM0024  KB05 MOLM-16 C517(2.51)  LDD3334  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Barrier-to-autointegration factor (BANF1) BAF family O75531

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255