Details of the Target

General Information of Target

Target ID LDTP09014
Target Name Sodium-dependent lysophosphatidylcholine symporter 1 (MFSD2A)
Gene Name MFSD2A
Gene ID 84879
Synonyms
MFSD2; NLS1; Sodium-dependent lysophosphatidylcholine symporter 1; NLS1; Sodium-dependent LPC symporter 1; Major facilitator superfamily domain-containing protein 2A; HsMFSD2A; MFSD2a
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAKGEGAESGSAAGLLPTSILQSTERPAQVKKEPKKKKQQLSVCNKLCYALGGAPYQVTG
CALGFFLQIYLLDVAQKDEEVVFCFSSFQVGPFSASIILFVGRAWDAITDPLVGLCISKS
PWTCLGRLMPWIIFSTPLAVIAYFLIWFVPDFPHGQTYWYLLFYCLFETMVTCFHVPYSA
LTMFISTEQTERDSATAYRMTVEVLGTVLGTAIQGQIVGQADTPCFQDLNSSTVASQSAN
HTHGTTSHRETQKAYLLAAGVIVCIYIICAVILILGVREQREPYEAQQSEPIAYFRGLRL
VMSHGPYIKLITGFLFTSLAFMLVEGNFVLFCTYTLGFRNEFQNLLLAIMLSATLTIPIW
QWFLTRFGKKTAVYVGISSAVPFLILVALMESNLIITYAVAVAAGISVAAAFLLPWSMLP
DVIDDFHLKQPHFHGTEPIFFSFYVFFTKFASGVSLGISTLSLDFAGYQTRGCSQPERVK
FTLNMLVTMAPIVLILLGLLLFKMYPIDEERRRQNKKALQALRDEASSSGCSETDSTELA
SIL
Target Bioclass
Transporter and channel
Family
Major facilitator superfamily
Subcellular location
Cell membrane
Function
Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function. Specifically expressed in endothelium of the blood-brain barrier of micro-vessels and transports LPC into the brain. Transport of LPC is essential because it constitutes the major mechanism by which docosahexaenoic acid (DHA), an omega-3 fatty acid that is essential for normal brain growth and cognitive function, enters the brain. Transports LPC carrying long-chain fatty acids such LPC oleate and LPC palmitate with a minimum acyl chain length of 14 carbons. Does not transport docosahexaenoic acid in unesterified fatty acid. Specifically required for blood-brain barrier formation and function, probably by mediating lipid transport. Not required for central nervous system vascular morphogenesis. Acts as a transporter for tunicamycin, an inhibitor of asparagine-linked glycosylation. In placenta, acts as a receptor for ERVFRD-1/syncytin-2 and is required for trophoblast fusion.
Uniprot ID
Q8NA29
Ensemble ID
ENST00000372809.5
HGNC ID
HGNC:25897

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C124(2.14)  LDD2186  [1]
DBIA
 Probe Info  		C473(1.20)  LDD1509  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0226  AC11 HEK-293T C473(1.20)  LDD1509  [2]
 LDCM0237  AC12 HEK-293T C473(1.03)  LDD1510  [2]
 LDCM0278  AC19 HEK-293T C473(0.99)  LDD1517  [2]
 LDCM0280  AC20 HEK-293T C473(0.97)  LDD1519  [2]
 LDCM0287  AC27 HEK-293T C473(0.92)  LDD1526  [2]
 LDCM0288  AC28 HEK-293T C473(1.29)  LDD1527  [2]
 LDCM0290  AC3 HEK-293T C473(0.94)  LDD1529  [2]
 LDCM0296  AC35 HEK-293T C473(1.15)  LDD1535  [2]
 LDCM0297  AC36 HEK-293T C473(1.25)  LDD1536  [2]
 LDCM0301  AC4 HEK-293T C473(1.09)  LDD1540  [2]
 LDCM0305  AC43 HEK-293T C473(1.24)  LDD1544  [2]
 LDCM0306  AC44 HEK-293T C473(1.21)  LDD1545  [2]
 LDCM0314  AC51 HEK-293T C473(0.90)  LDD1553  [2]
 LDCM0315  AC52 HEK-293T C473(1.28)  LDD1554  [2]
 LDCM0322  AC59 HEK-293T C473(1.22)  LDD1561  [2]
 LDCM0324  AC60 HEK-293T C473(1.33)  LDD1563  [2]
 LDCM0371  CL102 HEK-293T C473(0.99)  LDD1575  [2]
 LDCM0375  CL106 HEK-293T C473(1.03)  LDD1579  [2]
 LDCM0380  CL110 HEK-293T C473(0.87)  LDD1584  [2]
 LDCM0384  CL114 HEK-293T C473(1.18)  LDD1588  [2]
 LDCM0388  CL118 HEK-293T C473(0.70)  LDD1592  [2]
 LDCM0393  CL122 HEK-293T C473(0.88)  LDD1597  [2]
 LDCM0397  CL126 HEK-293T C473(0.82)  LDD1601  [2]
 LDCM0401  CL14 HEK-293T C473(0.97)  LDD1605  [2]
 LDCM0406  CL19 HEK-293T C473(1.19)  LDD1610  [2]
 LDCM0407  CL2 HEK-293T C473(0.79)  LDD1611  [2]
 LDCM0408  CL20 HEK-293T C473(1.29)  LDD1612  [2]
 LDCM0414  CL26 HEK-293T C473(1.26)  LDD1618  [2]
 LDCM0420  CL31 HEK-293T C473(1.89)  LDD1624  [2]
 LDCM0421  CL32 HEK-293T C473(1.14)  LDD1625  [2]
 LDCM0433  CL43 HEK-293T C473(1.09)  LDD1637  [2]
 LDCM0434  CL44 HEK-293T C473(1.19)  LDD1638  [2]
 LDCM0441  CL50 HEK-293T C473(0.98)  LDD1645  [2]
 LDCM0446  CL55 HEK-293T C473(1.38)  LDD1649  [2]
 LDCM0447  CL56 HEK-293T C473(1.48)  LDD1650  [2]
 LDCM0454  CL62 HEK-293T C473(1.09)  LDD1657  [2]
 LDCM0459  CL67 HEK-293T C473(1.14)  LDD1662  [2]
 LDCM0460  CL68 HEK-293T C473(1.37)  LDD1663  [2]
 LDCM0462  CL7 HEK-293T C473(1.55)  LDD1665  [2]
 LDCM0467  CL74 HEK-293T C473(0.87)  LDD1670  [2]
 LDCM0472  CL79 HEK-293T C473(0.89)  LDD1675  [2]
 LDCM0473  CL8 HEK-293T C473(2.46)  LDD1676  [2]
 LDCM0474  CL80 HEK-293T C473(1.21)  LDD1677  [2]
 LDCM0480  CL86 HEK-293T C473(0.91)  LDD1683  [2]
 LDCM0486  CL91 HEK-293T C473(1.35)  LDD1689  [2]
 LDCM0487  CL92 HEK-293T C473(1.53)  LDD1690  [2]
 LDCM0493  CL98 HEK-293T C473(0.96)  LDD1696  [2]
 LDCM0625  F8 Ramos C124(1.10)  LDD2187  [1]
 LDCM0573  Fragment11 Ramos C124(1.48)  LDD2190  [1]
 LDCM0582  Fragment23 Ramos C124(0.85)  LDD2196  [1]
 LDCM0578  Fragment27 Ramos C124(1.86)  LDD2197  [1]
 LDCM0586  Fragment28 Ramos C124(1.67)  LDD2198  [1]
 LDCM0588  Fragment30 Ramos C124(1.55)  LDD2199  [1]
 LDCM0589  Fragment31 Ramos C124(2.31)  LDD2200  [1]
 LDCM0468  Fragment33 Ramos C124(2.56)  LDD2202  [1]
 LDCM0427  Fragment51 HEK-293T C473(0.93)  LDD1631  [2]
 LDCM0614  Fragment56 Ramos C124(0.99)  LDD2205  [1]
 LDCM0569  Fragment7 Ramos C124(2.14)  LDD2186  [1]
 LDCM0022  KB02 CAL-148 C473(3.66)  LDD2285  [3]
 LDCM0023  KB03 CAL-148 C473(5.04)  LDD2702  [3]
 LDCM0024  KB05 CAL-148 C473(5.76)  LDD3119  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transmembrane protein 242 (TMEM242) TMEM242 family Q9NWH2

References

1 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840