Details of the Target

General Information of Target

Target ID LDTP09007
Target Name Protein BANP (BANP)
Gene Name BANP
Gene ID 54971
Synonyms
BEND1; SMAR1; Protein BANP; BEN domain-containing protein 1; Btg3-associated nuclear protein; Scaffold/matrix-associated region-1-binding protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MMSEHDLADVVQIAVEDLSPDHPVVLENHVVTDEDEPALKRQRLEINCQDPSIKTICLRL
DSIEAKLQALEATCKSLEEKLDLVTNKQHSPIQVPMVAGSPLGATQTCNKVRCVVPQTTV
ILNNDRQNAIVAKMEDPLSNRAPDSLENVISNAVPGRRQNTIVVKVPGQEDSHHEDGESG
SEASDSVSSCGQAGSQSIGSNVTLITLNSEEDYPNGTWLGDENNPEMRVRCAIIPSDMLH
ISTNCRTAEKMALTLLDYLFHREVQAVSNLSGQGKHGKKQLDPLTIYGIRCHLFYKFGIT
ESDWYRIKQSIDSKCRTAWRRKQRGQSLAVKSFSRRTPNSSSYCPSEPMMSTPPPASELP
QPQPQPQALHYALANAQQVQIHQIGEDGQVQVGHLHIAQVPQGEQVQITQDSEGNLQIHH
VGQDGQLLEATRIPCLLAPSVFKASSGQVLQGAQLIAVASSDPAAAGVDGSPLQGSDIQV
QYVQLAPVSDHTAGAQTAEALQPTLQPEMQLEHGAIQIQ
Target Bioclass
Other
Family
BANP/SMAR1 family
Subcellular location
Nucleus
Function
Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 activation, which causes cell cycle arrest.
Uniprot ID
Q8N9N5
Ensemble ID
ENST00000286122.11
HGNC ID
HGNC:13450

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
IPM
 Probe Info  		N.A.  LDD0241  [2]
DBIA
 Probe Info  		C48(24.06)  LDD0209  [3]
Acrolein
 Probe Info  		N.A.  LDD0222  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [6]
NAIA_4
 Probe Info  		N.A.  LDD2226  [7]
Compound 10
 Probe Info  		C435(0.00); C48(0.00)  LDD2216  [8]
ENE
 Probe Info  		N.A.  LDD0006  [9]
TFBX
 Probe Info  		C48(0.00); C435(0.00)  LDD0148  [10]
VSF
 Probe Info  		C435(0.00); C113(0.00); C48(0.00)  LDD0007  [9]
Methacrolein
 Probe Info  		N.A.  LDD0218  [4]
AOyne
 Probe Info  		15.00  LDD0443  [11]
NAIA_5
 Probe Info  		C113(0.00); C74(0.00)  LDD2223  [7]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C170
 Probe Info  		10.13  LDD1850  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0156  Aniline NCI-H1299 15.00  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [4]
 LDCM0632  CL-Sc Hep-G2 C74(1.61)  LDD2227  [7]
 LDCM0634  CY-0357 Hep-G2 C113(0.80); C48(0.70)  LDD2228  [7]
 LDCM0022  KB02 HEK-293T C48(1.02); C113(0.92); C108(1.17)  LDD1492  [13]
 LDCM0023  KB03 Jurkat C48(24.06)  LDD0209  [3]
 LDCM0024  KB05 HMCB C88(2.78)  LDD3312  [14]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 33 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
5'-AMP-activated protein kinase subunit beta-2 (PRKAB2) 5'-AMP-activated protein kinase beta subunit family O43741
AFG1-like ATPase (AFG1L) AFG1 ATPase family Q8WV93
Adenine nucleotide translocase lysine N-methyltransferase (ANTKMT) ANT/ATPSC lysine N-methyltransferase family Q9BQD7
DNA-directed RNA polymerases I, II, and III subunit RPABC5 (POLR2L) Archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family P62875
Casein kinase II subunit beta (CSNK2B) Casein kinase 2 subunit beta family P67870
Putative histone-lysine N-methyltransferase PRDM6 (PRDM6) Class V-like SAM-binding methyltransferase superfamily Q9NQX0
Phenylalanine--tRNA ligase, mitochondrial (FARS2) Class-II aminoacyl-tRNA synthetase family O95363
5-aminolevulinate synthase, erythroid-specific, mitochondrial (ALAS2) Class-II pyridoxal-phosphate-dependent aminotransferase family P22557
Peptidyl-prolyl cis-trans isomerase C (PPIC) Cyclophilin-type PPIase family P45877
Peptidyl-prolyl cis-trans isomerase F, mitochondrial (PPIF) Cyclophilin-type PPIase family P30405
Peptidyl-prolyl cis-trans isomerase B (PPIB) Cyclophilin-type PPIase family P23284
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 (NMNAT1) Eukaryotic NMN adenylyltransferase family Q9HAN9
Ribonuclease P protein subunit p25 (RPP25) Histone-like Alba family Q9BUL9
Cathepsin Z (CTSZ) Peptidase C1 family Q9UBR2
Cytosol aminopeptidase (LAP3) Peptidase M17 family P28838
26S proteasome non-ATPase regulatory subunit 9 (PSMD9) Proteasome subunit p27 family O00233
Serine/threonine-protein kinase 38 (STK38) AGC Ser/Thr protein kinase family Q15208
Protein kinase C alpha type (PRKCA) AGC Ser/Thr protein kinase family P17252
Calcium/calmodulin-dependent protein kinase type II subunit delta (CAMK2D) CAMK Ser/Thr protein kinase family Q13557
Serine/threonine-protein kinase pim-1 (PIM1) CAMK Ser/Thr protein kinase family P11309
Cell division cycle 7-related protein kinase (CDC7) Ser/Thr protein kinase family O00311
Dual specificity mitogen-activated protein kinase kinase 1 (MAP2K1) STE Ser/Thr protein kinase family Q02750
2-iminobutanoate/2-iminopropanoate deaminase (RIDA) RutC family P52758
E3 ubiquitin-protein ligase SH3RF2 (SH3RF2) SH3RF family Q8TEC5
Rho-related GTP-binding protein RhoH (RHOH) Rho family Q15669
Rho-related GTP-binding protein RhoQ (RHOQ) Rho family P17081
Helicase ARIP4 (RAD54L2) SNF2/RAD54 helicase family Q9Y4B4
TNF receptor-associated factor 2 (TRAF2) TNF receptor-associated factor family Q12933
TNF receptor-associated factor 4 (TRAF4) TNF receptor-associated factor family Q9BUZ4
Ribosome-releasing factor 2, mitochondrial (GFM2) Classic translation factor GTPase family Q969S9
Disintegrin and metalloproteinase domain-containing protein 15 (ADAM15) . Q13444
Nuclear receptor-interacting protein 2 (NRIP2) . Q9BQI9
Zinc finger MIZ domain-containing protein 2 (ZMIZ2) . Q8NF64
Transporter and channel
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein gamma (YWHAG) 14-3-3 family P61981
Flotillin-1 (FLOT1) Band 7/mec-2 family O75955
Monocarboxylate transporter 4 (SLC16A3) Monocarboxylate porter (TC 2.A.1.13) family O15427
MyoD family inhibitor (MDFI) MDFI family Q99750
Cellular tumor antigen p53 (TP53) P53 family P04637
SNARE-associated protein Snapin (SNAPIN) SNAPIN family O95295
Sperm protein associated with the nucleus on the X chromosome N2 (SPANXN2) SPAN-X family Q5MJ10
Transcription factor
Click To Hide/Show 29 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein CDX-4 (CDX4) Caudal homeobox family O14627
Homeobox protein DLX-3 (DLX3) Distal-less homeobox family O60479
Hairy/enhancer-of-split related with YRPW motif-like protein (HEYL) HEY family Q9NQ87
Thymocyte selection-associated high mobility group box protein TOX (TOX) High motility group (HMG) box superfamily O94900
Heat shock transcription factor, Y-linked (HSFY1; HSFY2) HSF family Q96LI6
Vascular endothelial zinc finger 1 (VEZF1) Krueppel C2H2-type zinc-finger protein family Q14119
Zinc finger protein 438 (ZNF438) Krueppel C2H2-type zinc-finger protein family Q7Z4V0
Zinc finger protein 512B (ZNF512B) Krueppel C2H2-type zinc-finger protein family Q96KM6
Protein max (MAX) MAX family P61244
Cone-rod homeobox protein (CRX) Paired homeobox family O43186
Paired box protein Pax-6 (PAX6) Paired homeobox family P26367
POU domain, class 6, transcription factor 2 (POU6F2) POU transcription factor family P78424
Krueppel-like factor 15 (KLF15) Sp1 C2H2-type zinc-finger protein family Q9UIH9
Transcription factor Sp2 (SP2) Sp1 C2H2-type zinc-finger protein family Q02086
Transcription factor Sp4 (SP4) Sp1 C2H2-type zinc-finger protein family Q02446
AT-rich interactive domain-containing protein 5A (ARID5A) . Q03989
Forkhead box protein M1 (FOXM1) . Q08050
Forkhead box protein R1 (FOXR1) . Q6PIV2
Golgin-45 (BLZF1) . Q9H2G9
Homeobox protein MOX-1 (MEOX1) . P50221
Homeobox protein notochord (NOTO) . A8MTQ0
LIM/homeobox protein Lhx4 (LHX4) . Q969G2
LIM/homeobox protein Lhx8 (LHX8) . Q68G74
Pogo transposable element with ZNF domain (POGZ) . Q7Z3K3
TOX high mobility group box family member 4 (TOX4) . O94842
Zinc finger and BTB domain-containing protein 4 (ZBTB4) . Q9P1Z0
Zinc finger protein 474 (ZNF474) . Q6S9Z5
Zinc finger protein 580 (ZNF580) . Q9UK33
Zinc finger protein 581 (ZNF581) . Q9P0T4
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hyaluronan and proteoglycan link protein 2 (HAPLN2) HAPLN family Q9GZV7
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-dependent transcription factor ATF-2 (ATF2) BZIP family P15336
Other
Click To Hide/Show 70 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Large ribosomal subunit protein bL28m (MRPL28) Bacterial ribosomal protein bL28 family Q13084
Enhancer of filamentation 1 (NEDD9) CAS family Q14511
Cyclin-dependent kinase inhibitor 1B (CDKN1B) CDI family P46527
Centrosomal protein of 76 kDa (CEP76) CEP76 family Q8TAP6
Cilia- and flagella-associated protein 206 (CFAP206) CFAP206 family Q8IYR0
Splicing factor YJU2 (YJU2) CWC16 family Q9BW85
Protein FAM217B (FAM217B) FAM217 family Q9NTX9
Protein FAM222B (FAM222B) FAM222 family Q8WU58
Protein FAM90A1 (FAM90A1) FAM90 family Q86YD7
X antigen family member 1 (XAGE1A; XAGE1B) GAGE family Q9HD64
Golgi-associated RAB2 interactor protein 6 (GARIN6) GARIN family Q8NEG0
GAS2-like protein 2 (GAS2L2) GAS2 family Q8NHY3
Golgin subfamily A member 6-like protein 9 (GOLGA6L9) GOLGA6 family A6NEM1
Keratin-associated protein 8-1 (KRTAP8-1) KRTAP type 8 family Q8IUC2
Zinc finger protein 488 (ZNF488) Krueppel C2H2-type zinc-finger protein family Q96MN9
Protein lin-54 homolog (LIN54) Lin-54 family Q6MZP7
Ligand-dependent nuclear receptor-interacting factor 1 (LRIF1) LRIF1 family Q5T3J3
Transcription termination factor 4, mitochondrial (MTERF4) MTERF family Q7Z6M4
Iron-sulfur cluster assembly enzyme ISCU (ISCU) NifU family Q9H1K1
Partitioning defective 6 homolog beta (PARD6B) PAR6 family Q9BYG5
PIH1 domain-containing protein 2 (PIH1D2) PIH1 family Q8WWB5
Proline-rich nuclear receptor coactivator 2 (PNRC2) PNRC family Q9NPJ4
Proline-rich protein 20D (PRR20D) PRR20 family P86480
Proline-rich protein 20E (PRR20E) PRR20 family P86478
Proline-rich protein 23B (PRR23B) PRR23 family Q6ZRT6
Folate transporter-like protein C2orf83 (C2orf83) Reduced folate carrier (RFC) transporter (TC 2.A.48) family Q53S99
Ribosome-recycling factor, mitochondrial (MRRF) RRF family Q96E11
Rab-3A-interacting protein (RAB3IP) SEC2 family Q96QF0
U6 snRNA-associated Sm-like protein LSm2 (LSM2) SnRNP Sm proteins family Q9Y333
Sperm acrosome membrane-associated protein 6 (SPACA6) SPACA6 family W5XKT8
Tenascin-X (TNXB) Tenascin family P22105
Synaptic plasticity regulator PANTS (C22orf39) UPF0545 family Q6P5X5
Zinc finger C2HC domain-containing protein 1C (ZC2HC1C) ZC2HC1 family Q53FD0
Ankyrin repeat domain-containing protein 55 (ANKRD55) . Q3KP44
BAG family molecular chaperone regulator 5 (BAG5) . Q9UL15
BRD4-interacting chromatin-remodeling complex-associated protein-like (BICRAL) . Q6AI39
BTB/POZ domain-containing protein KCTD9 (KCTD9) . Q7L273
Chromobox protein homolog 8 (CBX8) . Q9HC52
Collagen alpha-1(X) chain (COL10A1) . Q03692
Complement C1q tumor necrosis factor-related protein 2 (C1QTNF2) . Q9BXJ5
Doublecortin domain-containing protein 2B (DCDC2B) . A2VCK2
Endothelial cell-specific molecule 1 (ESM1) . Q9NQ30
Enkurin domain-containing protein 1 (ENKD1) . Q9H0I2
Four and a half LIM domains protein 2 (FHL2) . Q14192
Four and a half LIM domains protein 5 (FHL5) . Q5TD97
Galectin-4 (LGALS4) . P56470
INO80 complex subunit B (INO80B) . Q9C086
Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3) . Q96JM7
Leukocyte receptor cluster member 1 (LENG1) . Q96BZ8
LIM domain only protein 3 (LMO3) . Q8TAP4
LIM domain transcription factor LMO4 (LMO4) . P61968
PHD finger protein 21A (PHF21A) . Q96BD5
Placental protein 13-like (LGALS14) . Q8TCE9
Proline-rich protein 34 (PRR34) . Q9NV39
Protein FAM117B (FAM117B) . Q6P1L5
Protein SPMIP2 (SPMIP2) . Q96LM5
Psoriasis susceptibility 1 candidate gene 2 protein (PSORS1C2) . Q9UIG4
PTB-containing, cubilin and LRP1-interacting protein (PID1) . Q7Z2X4
RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 (RHNO1) . Q9BSD3
Rhombotin-1 (LMO1) . P25800
Rhombotin-2 (LMO2) . P25791
RING1 and YY1-binding protein (RYBP) . Q8N488
RNA-binding protein with multiple splicing (RBPMS) . Q93062
Steroid receptor-associated and regulated protein (SRARP) . Q8NEQ6
Storkhead-box protein 1 (STOX1) . Q6ZVD7
Tastin (TROAP) . Q12815
Ubiquitin-associated protein 2 (UBAP2) . Q5T6F2
Uncharacterized protein C1orf94 (C1orf94) . Q6P1W5
Uncharacterized protein C3orf36 (C3orf36) . Q3SXR2
Vimentin-type intermediate filament-associated coiled-coil protein (VMAC) . Q2NL98

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
12 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840