Details of the Target

General Information of Target

Target ID LDTP08959
Target Name Casein kinase I isoform alpha-like (CSNK1A1L)
Gene Name CSNK1A1L
Gene ID 122011
Synonyms
Casein kinase I isoform alpha-like; CKI-alpha-like; EC 2.7.11.1; CK1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTNNSGSKAELVVGGKYKLVRKIGSGSFGDVYLGITTTNGEDVAVKLESQKVKHPQLLYE
SKLYTILQGGVGIPHMHWYGQEKDNNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQM
ISRIEYVHTKNFLHRDIKPDNFLMGTGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKH
LIGTVRYASINAHLGIEQSRRDDMESLGYVFMYFNRTSLPWQGLRAMTKKQKYEKISEKK
MSTPVEVLCKGFPAEFAMYLNYCRGLRFEEVPDYMYLRQLFRILFRTLNHQYDYTFDWTM
LKQKAAQQAASSSGQGQQAQTQTGKQTEKNKNNVKDN
Target Bioclass
Enzyme
Family
Protein kinase superfamily, CK1 Ser/Thr protein kinase family, Casein kinase I subfamily
Subcellular location
Cytoplasm
Function
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling.
Uniprot ID
Q8N752
Ensemble ID
ENST00000379800.4
HGNC ID
HGNC:20289
ChEMBL ID
CHEMBL5520

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C291(2.02); C277(1.77)  LDD3310  [1]
IA-alkyne
 Probe Info  		C263(0.00); C249(0.00)  LDD0162  [2]
IPM
 Probe Info  		N.A.  LDD0025  [3]
TFBX
 Probe Info  		N.A.  LDD0027  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0625  F8 Ramos C249(0.81)  LDD2187  [4]
 LDCM0572  Fragment10 Ramos C249(0.90)  LDD2189  [4]
 LDCM0573  Fragment11 Ramos C249(0.57)  LDD2190  [4]
 LDCM0574  Fragment12 Ramos C249(0.80)  LDD2191  [4]
 LDCM0575  Fragment13 Ramos C249(1.01)  LDD2192  [4]
 LDCM0576  Fragment14 Ramos C249(0.45)  LDD2193  [4]
 LDCM0579  Fragment20 Ramos C249(0.78)  LDD2194  [4]
 LDCM0580  Fragment21 Ramos C249(0.76)  LDD2195  [4]
 LDCM0582  Fragment23 Ramos C249(1.20)  LDD2196  [4]
 LDCM0578  Fragment27 Ramos C249(0.90)  LDD2197  [4]
 LDCM0586  Fragment28 Ramos C249(0.50)  LDD2198  [4]
 LDCM0588  Fragment30 Ramos C249(1.11)  LDD2199  [4]
 LDCM0589  Fragment31 Ramos C249(1.10)  LDD2200  [4]
 LDCM0590  Fragment32 Ramos C249(0.70)  LDD2201  [4]
 LDCM0468  Fragment33 Ramos C249(1.21)  LDD2202  [4]
 LDCM0596  Fragment38 Ramos C249(0.93)  LDD2203  [4]
 LDCM0566  Fragment4 Ramos C249(0.83)  LDD2184  [4]
 LDCM0610  Fragment52 Ramos C249(1.24)  LDD2204  [4]
 LDCM0614  Fragment56 Ramos C249(1.21)  LDD2205  [4]
 LDCM0569  Fragment7 Ramos C249(1.05)  LDD2186  [4]
 LDCM0571  Fragment9 Ramos C249(0.85)  LDD2188  [4]
 LDCM0022  KB02 Ramos C249(0.57)  LDD2182  [4]
 LDCM0023  KB03 Ramos C249(0.81)  LDD2183  [4]
 LDCM0024  KB05 COLO792 C291(2.02); C277(1.77)  LDD3310  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578