Details of the Target

General Information of Target

Target ID LDTP08934
Target Name ADAMTS-like protein 1 (ADAMTSL1)
Gene Name ADAMTSL1
Gene ID 92949
Synonyms
ADAMTSR1; C9orf94; ADAMTS-like protein 1; ADAMTSL-1; Punctin-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MECCRRATPGTLLLFLAFLLLSSRTARSEEDRDGLWDAWGPWSECSRTCGGGASYSLRRC
LSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQQCSAHNDVKHHGQFYEWLPVSNDPDNPCS
LKCQAKGTTLVVELAPKVLDGTRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNG
DGSTCRLVRGQYKSQLSATKSDDTVVAIPYGSRHIRLVLKGPDHLYLETKTLQGTKGENS
LSSTGTFLVDNSSVDFQKFPDKEILRMAGPLTADFIVKIRNSGSADSTVQFIFYQPIIHR
WRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCP
ASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKC
MYTPKMPIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKTKP
HIKEECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCGV
GTQVRIVRCQVLLSFSQSVADLPIDECEGPKPASQRACYAGPCSGEIPEFNPDETDGLFG
GLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKS
CNLDPCPARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQPKPSTV
QACNRFNCPPAWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCSASKPACQ
QACKKDDCPSEWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVVNSTLCPPLPFSSS
IRPCMLATCARPGRPSTKHSPHIAAARKVYIQTRRQRKLHFVVGGFAYLLPKTAVVLRCP
ARRVRKPLITWEKDGQHLISSTHVTVAPFGYLKIHRLKPSDAGVYTCSAGPAREHFVIKL
IGGNRKLVARPLSPRSEEEVLAGRKGGPKEALQTHKHQNGIFSNGSKAEKRGLAANPGSR
YDDLVSRLLEQGGWPGELLASWEAQDSAERNTTSEEDPGAEQVLLHLPFTMVTEQRRLDD
ILGNLSQQPEELRDLYSKHLVAQLAQEIFRSHLEHQDTLLKPSERRTSPVTLSPHKHVSG
FSSSLRTSSTGDAGGGSRRPHRKPTILRKISAAQQLSASEVVTHLGQTVALASGTLSVLL
HCEAIGHPRPTISWARNGEEVQFSDRILLQPDDSLQILAPVEADVGFYTCNATNALGYDS
VSIAVTLAGKPLVKTSRMTVINTEKPAVTVDIGSTIKTVQGVNVTINCQVAGVPEAEVTW
FRNKSKLGSPHHLHEGSLLLTNVSSSDQGLYSCRAANLHGELTESTQLLILDPPQVPTQL
EDIRALLAATGPNLPSVLTSPLGTQLVLDPGNSALLGCPIKGHPVPNITWFHGGQPIVTA
TGLTHHILAAGQILQVANLSGGSQGEFSCLAQNEAGVLMQKASLVIQDYWWSVDRLATCS
ASCGNRGVQQPRLRCLLNSTEVNPAHCAGKVRPAVQPIACNRRDCPSRWMVTSWSACTRS
CGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLCVEWAFSSWGQCNG
PCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPRPVSTQNCWSEACSVHWRVSLWTLCTA
TCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQRCNITPCENMECRDTTRYCEKV
KQLKLCQLSQFKSRCCGTCGKA
Target Bioclass
Immunoglobulin
Subcellular location
Secreted, extracellular space, extracellular matrix
Uniprot ID
Q8N6G6
Ensemble ID
ENST00000276935.6
HGNC ID
HGNC:14632

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C241(1.39)  LDD3316  [1]
IA-alkyne
 Probe Info  		C1589(2.30)  LDD2182  [2]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0625  F8 Ramos C1589(0.94)  LDD2187  [2]
 LDCM0572  Fragment10 Ramos C1589(2.39)  LDD2189  [2]
 LDCM0574  Fragment12 Ramos C1589(1.46)  LDD2191  [2]
 LDCM0575  Fragment13 Ramos C1589(1.93)  LDD2192  [2]
 LDCM0576  Fragment14 Ramos C1589(1.04)  LDD2193  [2]
 LDCM0579  Fragment20 Ramos C1589(0.91)  LDD2194  [2]
 LDCM0580  Fragment21 Ramos C1589(0.95)  LDD2195  [2]
 LDCM0582  Fragment23 Ramos C1589(1.15)  LDD2196  [2]
 LDCM0578  Fragment27 Ramos C1589(2.28)  LDD2197  [2]
 LDCM0586  Fragment28 Ramos C1589(0.85)  LDD2198  [2]
 LDCM0588  Fragment30 Ramos C1589(1.12)  LDD2199  [2]
 LDCM0589  Fragment31 Ramos C1589(1.05)  LDD2200  [2]
 LDCM0590  Fragment32 Ramos C1589(1.63)  LDD2201  [2]
 LDCM0468  Fragment33 Ramos C1589(1.63)  LDD2202  [2]
 LDCM0596  Fragment38 Ramos C1589(0.86)  LDD2203  [2]
 LDCM0566  Fragment4 Ramos C1589(0.59)  LDD2184  [2]
 LDCM0610  Fragment52 Ramos C1589(0.79)  LDD2204  [2]
 LDCM0614  Fragment56 Ramos C1589(0.84)  LDD2205  [2]
 LDCM0569  Fragment7 Ramos C1589(1.24)  LDD2186  [2]
 LDCM0022  KB02 Ramos C1589(2.30)  LDD2182  [2]
 LDCM0023  KB03 Ramos C1589(2.11)  LDD2183  [2]
 LDCM0024  KB05 MEL167 C241(1.39)  LDD3316  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853