Details of the Target
General Information of Target
| Target ID | LDTP08879 | |||||
|---|---|---|---|---|---|---|
| Target Name | Actin filament-associated protein 1-like 2 (AFAP1L2) | |||||
| Gene Name | AFAP1L2 | |||||
| Gene ID | 84632 | |||||
| Synonyms |
KIAA1914; XB130; Actin filament-associated protein 1-like 2; AFAP1-like protein 2 |
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| 3D Structure | ||||||
| Sequence |
MERYKALEQLLTELDDFLKILDQENLSSTALVKKSCLAELLRLYTKSSSSDEEYIYMNKV
TINKQQNAESQGKAPEEQGLLPNGEPSQHSSAPQKSLPDLPPPKMIPERKQLAIPKTESP EGYYEEAEPYDTSLNEDGEAVSSSYESYDEEDGSKGKSAPYQWPSPEAGIELMRDARICA FLWRKKWLGQWAKQLCVIKDNRLLCYKSSKDHSPQLDVNLLGSSVIHKEKQVRKKEHKLK ITPMNADVIVLGLQSKDQAEQWLRVIQEVSGLPSEGASEGNQYTPDAQRFNCQKPDIAEK YLSASEYGSSVDGHPEVPETKDVKKKCSAGLKLSNLMNLGRKKSTSLEPVERSLETSSYL NVLVNSQWKSRWCSVRDNHLHFYQDRNRSKVAQQPLSLVGCEVVPDPSPDHLYSFRILHK GEELAKLEAKSSEEMGHWLGLLLSESGSKTDPEEFTYDYVDADRVSCIVSAAKNSLLLMQ RKFSEPNTYIDGLPSQDRQEELYDDVDLSELTAAVEPTEEATPVADDPNERESDRVYLDL TPVKSFLHGPSSAQAQASSPTLSCLDNATEALPADSGPGPTPDEPCIKCPENLGEQQLES LEPEDPSLRITTVKIQTEQQRISFPPSCPDAVVATPPGASPPVKDRLRVTSAEIKLGKNR TEAEVKRYTEEKERLEKKKEEIRGHLAQLRKEKRELKETLLKCTDKEVLASLEQKLKEID EECRGEESRRVDLELSIMEVKDNLKKAEAGPVTLGTTVDTTHLENVSPRPKAVTPASAPD CTPVNSATTLKNRPLSVVVTGKGTVLQKAKEWEKKGAS |
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| Target Bioclass |
Other
|
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| Subcellular location |
Cytoplasm
|
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| Function | May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation. | |||||
| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
| Cell line | Mutation details | Probe for labeling this protein in this cell | |||
|---|---|---|---|---|---|
| MOLT4 | SNV: p.P642H | . | |||
| NCIH1155 | SNV: p.M105I | . | |||
| OV90 | SNV: p.K33R | DBIA Probe Info | |||
| RCC10RGB | Insertion: p.C36Ter | . | |||
| TOV21G | SNV: p.E108Ter | DBIA Probe Info | |||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
STPyne Probe Info |
 |
K110(7.01); K228(10.00); K240(6.11); K33(0.35) | LDD0277 | [1] | |
|
DBIA Probe Info |
 |
C36(3.58) | LDD3312 | [2] | |
|
BTD Probe Info |
 |
C292(0.58) | LDD2091 | [3] | |
|
IPM Probe Info |
 |
C292(1.62); C36(1.32) | LDD1701 | [3] | |
Competitor(s) Related to This Target
| Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
|---|---|---|---|---|---|
| LDCM0539 | 3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile | MDA-MB-231 | C292(0.68) | LDD2132 | [3] |
| LDCM0498 | BS-3668 | MDA-MB-231 | C292(0.58) | LDD2091 | [3] |
| LDCM0213 | Electrophilic fragment 2 | MDA-MB-231 | C292(1.51) | LDD1702 | [3] |
| LDCM0022 | KB02 | 42-MG-BA | C36(1.04) | LDD2244 | [2] |
| LDCM0023 | KB03 | MDA-MB-231 | C292(1.62); C36(1.32) | LDD1701 | [3] |
| LDCM0024 | KB05 | HMCB | C36(3.58) | LDD3312 | [2] |
| LDCM0528 | N-(4-bromophenyl)-2-cyano-N-phenylacetamide | MDA-MB-231 | C292(0.56) | LDD2121 | [3] |
| LDCM0499 | Nucleophilic fragment 12b | MDA-MB-231 | C327(1.15) | LDD2092 | [3] |
| LDCM0501 | Nucleophilic fragment 13b | MDA-MB-231 | C327(1.01) | LDD2094 | [3] |
| LDCM0506 | Nucleophilic fragment 16a | MDA-MB-231 | C36(0.77) | LDD2099 | [3] |
| LDCM0511 | Nucleophilic fragment 18b | MDA-MB-231 | C292(1.08) | LDD2104 | [3] |
| LDCM0514 | Nucleophilic fragment 20a | MDA-MB-231 | C467(1.05) | LDD2107 | [3] |
| LDCM0525 | Nucleophilic fragment 25b | MDA-MB-231 | C292(1.00) | LDD2118 | [3] |
| LDCM0527 | Nucleophilic fragment 26b | MDA-MB-231 | C292(0.79) | LDD2120 | [3] |
| LDCM0530 | Nucleophilic fragment 28a | MDA-MB-231 | C36(0.98) | LDD2123 | [3] |
| LDCM0542 | Nucleophilic fragment 37 | MDA-MB-231 | C292(0.81) | LDD2135 | [3] |
| LDCM0546 | Nucleophilic fragment 40 | MDA-MB-231 | C292(0.86) | LDD2140 | [3] |
| LDCM0549 | Nucleophilic fragment 43 | MDA-MB-231 | C467(0.99) | LDD2143 | [3] |
| LDCM0552 | Nucleophilic fragment 6a | MDA-MB-231 | C467(0.92) | LDD2146 | [3] |
References