Details of the Target

General Information of Target

Target ID LDTP08869
Target Name Coiled-coil domain-containing protein 24 (CCDC24)
Gene Name CCDC24
Gene ID 149473
Synonyms
Coiled-coil domain-containing protein 24
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MLRHSPSLWELVEEHVPLRERREVKRILGEAAVDLSLELRAEVAMLRALLQEARSSQAPS
SRPISDPSSLLAPPPLLKDLLRQELRQLLQGLRHKAICEGRDQAQAWVQYSPRVLHFALE
EPRCDLPEQEIFQMRGGGPSSGHRDLSIIKDQLNVSNIDQVARHLRGLLEEECHTLEREI
LILQRCLEEEYLRPCHPSEAALEPTLAELKEQKKAMEQELQASVGPSCVSPNHRQRPLGS
STQGLRPPLPLCGVAPLQCCLPAPPLEPYLRPRGQSATHRWGRQLQCSPREGPASTPMSS
AAPQAPA
Target Bioclass
Other
Uniprot ID
Q8N4L8
Ensemble ID
ENST00000372318.8
HGNC ID
HGNC:28688

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HUCCT1 SNV: p.E203D .
Ishikawa (Heraklio) 02 ER SNV: p.A118V .
J82 SNV: p.E179Ter .
LN229 SNV: p.I149M .
PEO1 SNV: p.P139L .
RKO SNV: p.G253V .
SW837 SNV: p.H116Q .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
CY4
 Probe Info  		E13(0.00); E14(0.00)  LDD0247  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Adenine nucleotide translocase lysine N-methyltransferase (ANTKMT) ANT/ATPSC lysine N-methyltransferase family Q9BQD7
Cell division cycle protein 23 homolog (CDC23) APC8/CDC23 family Q9UJX2
NADH dehydrogenase 1 beta subcomplex subunit 7 (NDUFB7) Complex I NDUFB7 subunit family P17568
Protein farnesyltransferase subunit beta (FNTB) Protein prenyltransferase subunit beta family P49356
Tripartite motif-containing protein 42 (TRIM42) TRIM/RBCC family Q8IWZ5
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein Aiolos (IKZF3) Ikaros C2H2-type zinc-finger protein family Q9UKT9
Erythroid transcription factor (GATA1) . P15976
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Alpha-2C adrenergic receptor (ADRA2C) G-protein coupled receptor 1 family P18825
Other
Click To Hide/Show 18 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Acyl carrier protein, mitochondrial (NDUFAB1) Acyl carrier protein (ACP) family O14561
A-kinase anchor protein 8-like (AKAP8L) AKAP95 family Q9ULX6
Keratin, type I cuticular Ha3-II (KRT33B) Intermediate filament family Q14525
Keratin, type I cuticular Ha4 (KRT34) Intermediate filament family O76011
Keratin-associated protein 19-1 (KRTAP19-1) KRTAP type 19 family Q8IUB9
Keratin-associated protein 19-6 (KRTAP19-6) KRTAP type 19 family Q3LI70
Keratin-associated protein 19-7 (KRTAP19-7) KRTAP type 19 family Q3SYF9
Keratin-associated protein 6-1 (KRTAP6-1) KRTAP type 6 family Q3LI64
Harmonin-binding protein USHBP1 (USHBP1) MCC family Q8N6Y0
Protein Mis18-beta (OIP5) Mis18 family O43482
Keratin-associated protein 13-2 (KRTAP13-2) PMG family Q52LG2
Keratin-associated protein 15-1 (KRTAP15-1) PMG family Q3LI76
Transcription elongation factor A protein-like 8 (TCEAL8) TFS-II family Q8IYN2
Thyroid receptor-interacting protein 6 (TRIP6) Zyxin/ajuba family Q15654
LRP2-binding protein (LRP2BP) . Q9P2M1
Melanoma-associated antigen 6 (MAGEA6) . P43360
Tetratricopeptide repeat protein 23-like (TTC23L) . Q6PF05
Zinc finger MYND domain-containing protein 12 (ZMYND12) . Q9H0C1

References

1 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.