Details of the Target

General Information of Target

Target ID LDTP08829
Target Name Maturin (MTURN)
Gene Name MTURN
Gene ID 222166
Synonyms
C7orf41; Maturin; Maturin neural progenitor differentiation regulator protein homolog; Protein Ells1
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MDFQQLADVAEKWCSNTPFELIATEETERRMDFYADPGVSFYVLCPDNGCGDNFHVWSES
EDCLPFLQLAQDYISSCGKKTLHEVLEKVFKSFRPLLGLPDADDDAFEEYSADVEEEEPE
ADHPQMGVSQQ
Target Bioclass
Other
Family
MTURN family
Subcellular location
Cytoplasm
Function
Promotes megakaryocyte differentiation by enhancing ERK and JNK signaling as well as up-regulating RUNX1 and FLI1 expression. Represses NF-kappa-B transcriptional activity by inhibiting phosphorylation of RELA at 'Ser-536'. May be involved in early neuronal development.
Uniprot ID
Q8N3F0
Ensemble ID
ENST00000324453.13
HGNC ID
HGNC:25457

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.D105G .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C14(0.51)  LDD1507  [1]
NAIA_5
 Probe Info  		N.A.  LDD2223  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C14(0.51)  LDD1507  [1]
 LDCM0270  AC15 HEK-293T C14(0.92)  LDD1513  [1]
 LDCM0276  AC17 HEK-293T C14(0.73)  LDD1515  [1]
 LDCM0283  AC23 HEK-293T C14(0.92)  LDD1522  [1]
 LDCM0285  AC25 HEK-293T C14(0.78)  LDD1524  [1]
 LDCM0292  AC31 HEK-293T C14(1.22)  LDD1531  [1]
 LDCM0294  AC33 HEK-293T C14(0.73)  LDD1533  [1]
 LDCM0300  AC39 HEK-293T C14(1.31)  LDD1539  [1]
 LDCM0303  AC41 HEK-293T C14(0.57)  LDD1542  [1]
 LDCM0309  AC47 HEK-293T C14(1.13)  LDD1548  [1]
 LDCM0311  AC49 HEK-293T C14(0.57)  LDD1550  [1]
 LDCM0318  AC55 HEK-293T C14(0.91)  LDD1557  [1]
 LDCM0320  AC57 HEK-293T C14(1.03)  LDD1559  [1]
 LDCM0327  AC63 HEK-293T C14(0.86)  LDD1566  [1]
 LDCM0334  AC7 HEK-293T C14(0.88)  LDD1568  [1]
 LDCM0356  AKOS034007680 HEK-293T C14(1.21)  LDD1570  [1]
 LDCM0379  CL11 HEK-293T C14(0.94)  LDD1583  [1]
 LDCM0404  CL17 HEK-293T C14(0.60)  LDD1608  [1]
 LDCM0411  CL23 HEK-293T C14(0.95)  LDD1615  [1]
 LDCM0417  CL29 HEK-293T C14(0.48)  LDD1621  [1]
 LDCM0424  CL35 HEK-293T C14(1.40)  LDD1628  [1]
 LDCM0431  CL41 HEK-293T C14(0.55)  LDD1635  [1]
 LDCM0437  CL47 HEK-293T C14(1.23)  LDD1641  [1]
 LDCM0440  CL5 HEK-293T C14(0.70)  LDD1644  [1]
 LDCM0444  CL53 HEK-293T C14(0.02)  LDD1647  [1]
 LDCM0450  CL59 HEK-293T C14(1.00)  LDD1653  [1]
 LDCM0457  CL65 HEK-293T C14(1.09)  LDD1660  [1]
 LDCM0464  CL71 HEK-293T C14(0.96)  LDD1667  [1]
 LDCM0470  CL77 HEK-293T C14(0.38)  LDD1673  [1]
 LDCM0477  CL83 HEK-293T C14(1.00)  LDD1680  [1]
 LDCM0483  CL89 HEK-293T C14(1.18)  LDD1686  [1]
 LDCM0490  CL95 HEK-293T C14(0.96)  LDD1693  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264