Details of the Target

General Information of Target

Target ID LDTP08727
Target Name Synaptonemal complex central element protein 1 (SYCE1)
Gene Name SYCE1
Gene ID 93426
Synonyms
C10orf94; Synaptonemal complex central element protein 1; Cancer/testis antigen 76; CT76
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGRSLTSKAEPTAGAVDRAEKAGGQDTSSQKIEDLMEMVQKLQKVGSLEPRVEVLINRI
NEVQQAKKKANKDLGEARTICEALQKELDSLHGEKVHLKEILSKKQETLRILRLHCQEKE
SEAHRKHTMLQECKERISALNLQIEEEKNKQRQLRLAFEEQLEDLMGQHKDLWDFHMPER
LAKEICALDSSKEQLLKEEKLVKATLEDVKHQLCSLCGAEGPSTLDEGLFLRSQEAAATV
QLFQEEHRKAEELLAAAAQRHQQLQQKCQQQQQKRQRLKEELEKHGMQVPAQAQSTQEEE
AGPGDVASPKPLKGERPGAAHQAGPDVLIGQEDTLHPDLSPRGFQEIKELF
Target Bioclass
Other
Family
SYCE family
Subcellular location
Nucleus
Function
Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Requires SYCP1 in order to be incorporated into the central element. May have a role in the synaptonemal complex assembly, stabilization and recombination.
Uniprot ID
Q8N0S2
Ensemble ID
ENST00000343131.7
HGNC ID
HGNC:28852

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HEC1 SNV: p.R275W .
IGR1 SNV: p.G3R .
MKN45 SNV: p.G24R .
SKMM2 SNV: p.A157T .
TE1 SNV: p.Q263K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C268(1.08)  LDD2183  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0625  F8 Ramos C268(0.98)  LDD2187  [1]
 LDCM0573  Fragment11 Ramos C268(8.56)  LDD2190  [1]
 LDCM0575  Fragment13 Ramos C268(1.09)  LDD2192  [1]
 LDCM0576  Fragment14 Ramos C268(0.72)  LDD2193  [1]
 LDCM0580  Fragment21 Ramos C268(1.21)  LDD2195  [1]
 LDCM0582  Fragment23 Ramos C268(0.73)  LDD2196  [1]
 LDCM0578  Fragment27 Ramos C268(1.27)  LDD2197  [1]
 LDCM0586  Fragment28 Ramos C268(0.65)  LDD2198  [1]
 LDCM0588  Fragment30 Ramos C268(1.84)  LDD2199  [1]
 LDCM0589  Fragment31 Ramos C268(0.93)  LDD2200  [1]
 LDCM0468  Fragment33 Ramos C268(1.26)  LDD2202  [1]
 LDCM0596  Fragment38 Ramos C268(1.01)  LDD2203  [1]
 LDCM0566  Fragment4 Ramos C268(0.74)  LDD2184  [1]
 LDCM0610  Fragment52 Ramos C268(1.71)  LDD2204  [1]
 LDCM0614  Fragment56 Ramos C268(2.18)  LDD2205  [1]
 LDCM0569  Fragment7 Ramos C268(0.67)  LDD2186  [1]
 LDCM0023  KB03 Ramos C268(1.08)  LDD2183  [1]

References

1 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578