Details of the Target

General Information of Target

Target ID LDTP08681
Target Name Cilium assembly protein DZIP1L (DZIP1L)
Gene Name DZIP1L
Gene ID 199221
Synonyms
Cilium assembly protein DZIP1L; DAZ-interacting zinc finger protein 1-like
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQSPAATAEGLSGPLFGAYTFPTFKFQPRHDSMDWRRISTLDVDRVARELDVATLQENIA
GITFCNLDREVCSRCGQPVDPALLKVLRLAQLIIEYLLHCQDCLSASVAQLEARLQTSLG
QQQRGQQELGRQADELKGVREESRRRRKMISTLQQLLMQTGTHSYHTCHLCDKTFMNATF
LRGHIQRRHAGVAEGGKQKKQEQPVEEVLEELRAKLKWTQGELEAQREAERQRQLQEAEL
IHQREIEAKKEFDKWKEQEWTKLYGEIDKLKKLFWDEFKNVAKQNSTLEEKLRALQSHSV
MESKLGSLRDEESEEWLRQARELQALREKTEIQKTEWKRKVKELHEEHMAEKKELQEENQ
RLQASLSQDQKKAAAQSQCQISTLRAQLQEQARIIASQEEMIQSLSLRKVEGIHKVPKAV
DTEEDSPEEEMEDSQDEQHKVLAALRRNPTLLKHFRPILEDTLEEKLESMGIRKDAKGIS
IQTLRHLESLLRVQREQKARKFSEFLSLRGKLVKEVTSRAKERQENGAVVSQPDGQPSVK
SQQSTLVTREAQPKTRTLQVALPSTPAEPPPPTRQSHGSHGSSLTQVSAPAPRPGLHGPS
STPPSSGPGMSTPPFSSEEDSEGDRVQRVSLQPPKVPSRMVPRPKDDWDWSDTETSEENA
QPPGQGSGTLVQSMVKNLEKQLEAPAKKPAGGVSLFFMPNAGPQRAATPGRKPQLSEDES
DLEISSLEDLPLDLDQREKPKPLSRSKLPEKFGTGPQSSGQPRVPAW
Target Bioclass
Other
Family
DZIP C2H2-type zinc-finger protein family
Subcellular location
Cytoplasm, cytoskeleton, cilium basal body
Function Involved in primary cilium formation. Probably acts as a transition zone protein required for localization of PKD1/PC1 and PKD2/PC2 to the ciliary membrane.
Uniprot ID
Q8IYY4
Ensemble ID
ENST00000327532.7
HGNC ID
HGNC:26551

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
8305C SNV: p.P599S .
8505C SNV: p.R146S .
COLO320 SNV: p.Q363P .
COLO678 SNV: p.P634Q .
HCT15 SNV: p.A106V; p.P633L .
HT29 SNV: p.R492S .
JHH7 SNV: p.P756Q .
KYSE410 SNV: p.H298Y .
MCC13 SNV: p.P765S .
MDAMB453 SNV: p.D134Y .
MELJUSO SNV: p.G578A .
NCIH2286 SNV: p.D268E .
NCIH358 SNV: p.S600A .
ONS76 SNV: p.L366V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C379(1.01)  LDD1510  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0237  AC12 HEK-293T C379(1.01)  LDD1510  [2]
 LDCM0280  AC20 HEK-293T C379(1.22)  LDD1519  [2]
 LDCM0288  AC28 HEK-293T C379(1.01)  LDD1527  [2]
 LDCM0297  AC36 HEK-293T C379(0.95)  LDD1536  [2]
 LDCM0301  AC4 HEK-293T C379(1.18)  LDD1540  [2]
 LDCM0306  AC44 HEK-293T C379(0.98)  LDD1545  [2]
 LDCM0315  AC52 HEK-293T C379(1.23)  LDD1554  [2]
 LDCM0324  AC60 HEK-293T C379(1.18)  LDD1563  [2]
 LDCM0367  CL1 HEK-293T C379(0.90)  LDD1571  [2]
 LDCM0370  CL101 HEK-293T C379(0.72)  LDD1574  [2]
 LDCM0374  CL105 HEK-293T C379(0.85)  LDD1578  [2]
 LDCM0378  CL109 HEK-293T C379(0.97)  LDD1582  [2]
 LDCM0383  CL113 HEK-293T C379(0.92)  LDD1587  [2]
 LDCM0387  CL117 HEK-293T C379(0.97)  LDD1591  [2]
 LDCM0392  CL121 HEK-293T C379(0.81)  LDD1596  [2]
 LDCM0396  CL125 HEK-293T C379(1.00)  LDD1600  [2]
 LDCM0400  CL13 HEK-293T C379(1.14)  LDD1604  [2]
 LDCM0408  CL20 HEK-293T C379(1.09)  LDD1612  [2]
 LDCM0413  CL25 HEK-293T C379(1.18)  LDD1617  [2]
 LDCM0421  CL32 HEK-293T C379(1.88)  LDD1625  [2]
 LDCM0426  CL37 HEK-293T C379(0.83)  LDD1630  [2]
 LDCM0434  CL44 HEK-293T C379(0.96)  LDD1638  [2]
 LDCM0439  CL49 HEK-293T C379(0.90)  LDD1643  [2]
 LDCM0447  CL56 HEK-293T C379(1.48)  LDD1650  [2]
 LDCM0453  CL61 HEK-293T C379(1.07)  LDD1656  [2]
 LDCM0460  CL68 HEK-293T C379(1.15)  LDD1663  [2]
 LDCM0466  CL73 HEK-293T C379(0.77)  LDD1669  [2]
 LDCM0473  CL8 HEK-293T C379(1.40)  LDD1676  [2]
 LDCM0474  CL80 HEK-293T C379(0.85)  LDD1677  [2]
 LDCM0479  CL85 HEK-293T C379(0.82)  LDD1682  [2]
 LDCM0487  CL92 HEK-293T C379(1.21)  LDD1690  [2]
 LDCM0492  CL97 HEK-293T C379(1.18)  LDD1695  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase TRIM37 (TRIM37) TRIM/RBCC family O94972
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AP-4 complex accessory subunit Tepsin (TEPSIN) . Q96N21
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Angiomotin-like protein 2 (AMOTL2) Angiomotin family Q9Y2J4
Centrosomal protein of 76 kDa (CEP76) CEP76 family Q8TAP6
Protein chibby homolog 1 (CBY1) Chibby family Q9Y3M2
Protein chibby homolog 2 (CBY2) Chibby family Q8NA61
Paraneoplastic antigen-like protein 5 (PNMA5) PNMA family Q96PV4
Leucine-rich repeat neuronal protein 4 (LRRN4) . Q8WUT4

References

1 Labeling Preferences of Diazirines with Protein Biomolecules. J Am Chem Soc. 2021 May 5;143(17):6691-6700. doi: 10.1021/jacs.1c02509. Epub 2021 Apr 20.
Mass spectrometry data entry: PXD025140
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402