Details of the Target

General Information of Target

Target ID LDTP08662
Target Name Palmitoyltransferase ZDHHC23 (ZDHHC23)
Gene Name ZDHHC23
Gene ID 254887
Synonyms
Palmitoyltransferase ZDHHC23; EC 2.3.1.225; Zinc finger DHHC domain-containing protein 23; DHHC-23; zDHHC23
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTQKGSMKPVKKKKTEEPELEPLCCCEYIDRNGEKNHVATCLCDCQDLDEGCDRWITCKS
LQPETCERIMDTISDRLRIPWLRGAKKVNISIIPPLVLLPVFLHVASWHFLLGVVVLTSL
PVLALWYYYLTHRRKEQTLFFLSLGLFSLGYMYYVFLQEVVPKGRVGPVQLAVLTCGLFL
ILLALHRAKKNPGYLSNPASGDRSLSSSQLECLSRKGQEKTKGFPGADMSGSLNNRTTKD
DPKGSSKMPAGSPTKAKEDWCAKCQLVRPARAWHCRICGICVRRMDHHCVWINSCVGESN
HQAFILALLIFLLTSVYGITLTLDTICRDRSVFTALFYCPGVYANYSSALSFTCVWYSVI
ITAGMAYIFLIQLINISYNVTEREVQQALRQKTGRRLLCGLIVDTGLLG
Target Bioclass
Enzyme
Family
DHHC palmitoyltransferase family
Subcellular location
Golgi apparatus membrane
Function
Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates and be involved in a variety of cellular processes (Probable). Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane. May be involved in NOS1 regulation and targeting to the synaptic membrane.
Uniprot ID
Q8IYP9
Ensemble ID
ENST00000330212.7
HGNC ID
HGNC:28654

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		C278(0.00); C281(0.00)  LDD0241  [1]
DBIA
 Probe Info  		C212(2.57)  LDD3319  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C212(1.10)  LDD1507  [3]
 LDCM0215  AC10 HEK-293T C212(0.88)  LDD1508  [3]
 LDCM0226  AC11 HEK-293T C212(1.07)  LDD1509  [3]
 LDCM0259  AC14 HEK-293T C212(1.09)  LDD1512  [3]
 LDCM0276  AC17 HEK-293T C212(1.09)  LDD1515  [3]
 LDCM0277  AC18 HEK-293T C212(0.95)  LDD1516  [3]
 LDCM0278  AC19 HEK-293T C212(1.10)  LDD1517  [3]
 LDCM0279  AC2 HEK-293T C212(0.89)  LDD1518  [3]
 LDCM0282  AC22 HEK-293T C212(0.96)  LDD1521  [3]
 LDCM0285  AC25 HEK-293T C212(1.13)  LDD1524  [3]
 LDCM0286  AC26 HEK-293T C212(1.09)  LDD1525  [3]
 LDCM0287  AC27 HEK-293T C212(1.05)  LDD1526  [3]
 LDCM0290  AC3 HEK-293T C212(1.05)  LDD1529  [3]
 LDCM0291  AC30 HEK-293T C212(0.99)  LDD1530  [3]
 LDCM0294  AC33 HEK-293T C212(1.08)  LDD1533  [3]
 LDCM0295  AC34 HEK-293T C212(0.93)  LDD1534  [3]
 LDCM0296  AC35 HEK-293T C212(1.08)  LDD1535  [3]
 LDCM0299  AC38 HEK-293T C212(1.24)  LDD1538  [3]
 LDCM0303  AC41 HEK-293T C212(1.12)  LDD1542  [3]
 LDCM0304  AC42 HEK-293T C212(0.93)  LDD1543  [3]
 LDCM0305  AC43 HEK-293T C212(1.01)  LDD1544  [3]
 LDCM0308  AC46 HEK-293T C212(1.11)  LDD1547  [3]
 LDCM0311  AC49 HEK-293T C212(1.05)  LDD1550  [3]
 LDCM0313  AC50 HEK-293T C212(1.01)  LDD1552  [3]
 LDCM0314  AC51 HEK-293T C212(1.00)  LDD1553  [3]
 LDCM0317  AC54 HEK-293T C212(1.10)  LDD1556  [3]
 LDCM0320  AC57 HEK-293T C212(1.12)  LDD1559  [3]
 LDCM0321  AC58 HEK-293T C212(0.96)  LDD1560  [3]
 LDCM0322  AC59 HEK-293T C212(1.01)  LDD1561  [3]
 LDCM0323  AC6 HEK-293T C212(1.03)  LDD1562  [3]
 LDCM0326  AC62 HEK-293T C212(0.99)  LDD1565  [3]
 LDCM0356  AKOS034007680 HEK-293T C212(1.10)  LDD1570  [3]
 LDCM0367  CL1 HEK-293T C212(1.06)  LDD1571  [3]
 LDCM0368  CL10 HEK-293T C212(1.28)  LDD1572  [3]
 LDCM0370  CL101 HEK-293T C212(1.07)  LDD1574  [3]
 LDCM0371  CL102 HEK-293T C212(1.12)  LDD1575  [3]
 LDCM0372  CL103 HEK-293T C212(0.96)  LDD1576  [3]
 LDCM0374  CL105 HEK-293T C212(1.14)  LDD1578  [3]
 LDCM0375  CL106 HEK-293T C212(0.94)  LDD1579  [3]
 LDCM0376  CL107 HEK-293T C212(1.07)  LDD1580  [3]
 LDCM0378  CL109 HEK-293T C212(1.02)  LDD1582  [3]
 LDCM0380  CL110 HEK-293T C212(1.18)  LDD1584  [3]
 LDCM0381  CL111 HEK-293T C212(0.83)  LDD1585  [3]
 LDCM0383  CL113 HEK-293T C212(0.96)  LDD1587  [3]
 LDCM0384  CL114 HEK-293T C212(0.98)  LDD1588  [3]
 LDCM0385  CL115 HEK-293T C212(1.09)  LDD1589  [3]
 LDCM0387  CL117 HEK-293T C212(1.10)  LDD1591  [3]
 LDCM0388  CL118 HEK-293T C212(1.11)  LDD1592  [3]
 LDCM0389  CL119 HEK-293T C212(0.94)  LDD1593  [3]
 LDCM0392  CL121 HEK-293T C212(1.06)  LDD1596  [3]
 LDCM0393  CL122 HEK-293T C212(0.91)  LDD1597  [3]
 LDCM0394  CL123 HEK-293T C212(0.96)  LDD1598  [3]
 LDCM0396  CL125 HEK-293T C212(1.01)  LDD1600  [3]
 LDCM0397  CL126 HEK-293T C212(1.05)  LDD1601  [3]
 LDCM0398  CL127 HEK-293T C212(1.02)  LDD1602  [3]
 LDCM0400  CL13 HEK-293T C212(1.17)  LDD1604  [3]
 LDCM0401  CL14 HEK-293T C212(0.89)  LDD1605  [3]
 LDCM0402  CL15 HEK-293T C212(1.11)  LDD1606  [3]
 LDCM0404  CL17 HEK-293T C212(1.42)  LDD1608  [3]
 LDCM0405  CL18 HEK-293T C212(1.04)  LDD1609  [3]
 LDCM0406  CL19 HEK-293T C212(1.00)  LDD1610  [3]
 LDCM0407  CL2 HEK-293T C212(1.06)  LDD1611  [3]
 LDCM0410  CL22 HEK-293T C212(1.27)  LDD1614  [3]
 LDCM0413  CL25 HEK-293T C212(1.15)  LDD1617  [3]
 LDCM0414  CL26 HEK-293T C212(1.03)  LDD1618  [3]
 LDCM0415  CL27 HEK-293T C212(1.13)  LDD1619  [3]
 LDCM0417  CL29 HEK-293T C212(1.25)  LDD1621  [3]
 LDCM0418  CL3 HEK-293T C212(1.18)  LDD1622  [3]
 LDCM0419  CL30 HEK-293T C212(0.94)  LDD1623  [3]
 LDCM0420  CL31 HEK-293T C212(1.08)  LDD1624  [3]
 LDCM0423  CL34 HEK-293T C212(1.15)  LDD1627  [3]
 LDCM0426  CL37 HEK-293T C212(1.13)  LDD1630  [3]
 LDCM0428  CL39 HEK-293T C212(1.12)  LDD1632  [3]
 LDCM0431  CL41 HEK-293T C212(1.30)  LDD1635  [3]
 LDCM0432  CL42 HEK-293T C212(1.05)  LDD1636  [3]
 LDCM0433  CL43 HEK-293T C212(0.99)  LDD1637  [3]
 LDCM0436  CL46 HEK-293T C212(0.99)  LDD1640  [3]
 LDCM0439  CL49 HEK-293T C212(0.92)  LDD1643  [3]
 LDCM0440  CL5 HEK-293T C212(1.13)  LDD1644  [3]
 LDCM0441  CL50 HEK-293T C212(0.93)  LDD1645  [3]
 LDCM0444  CL53 HEK-293T C212(1.08)  LDD1647  [3]
 LDCM0445  CL54 HEK-293T C212(1.09)  LDD1648  [3]
 LDCM0446  CL55 HEK-293T C212(1.11)  LDD1649  [3]
 LDCM0449  CL58 HEK-293T C212(1.19)  LDD1652  [3]
 LDCM0451  CL6 HEK-293T C212(1.10)  LDD1654  [3]
 LDCM0453  CL61 HEK-293T C212(0.91)  LDD1656  [3]
 LDCM0454  CL62 HEK-293T C212(0.94)  LDD1657  [3]
 LDCM0455  CL63 HEK-293T C212(0.98)  LDD1658  [3]
 LDCM0457  CL65 HEK-293T C212(1.03)  LDD1660  [3]
 LDCM0458  CL66 HEK-293T C212(1.13)  LDD1661  [3]
 LDCM0459  CL67 HEK-293T C212(1.18)  LDD1662  [3]
 LDCM0462  CL7 HEK-293T C212(1.00)  LDD1665  [3]
 LDCM0463  CL70 HEK-293T C212(1.38)  LDD1666  [3]
 LDCM0466  CL73 HEK-293T C212(0.97)  LDD1669  [3]
 LDCM0467  CL74 HEK-293T C212(0.98)  LDD1670  [3]
 LDCM0470  CL77 HEK-293T C212(1.50)  LDD1673  [3]
 LDCM0471  CL78 HEK-293T C212(0.93)  LDD1674  [3]
 LDCM0472  CL79 HEK-293T C212(1.09)  LDD1675  [3]
 LDCM0476  CL82 HEK-293T C212(1.02)  LDD1679  [3]
 LDCM0479  CL85 HEK-293T C212(0.96)  LDD1682  [3]
 LDCM0480  CL86 HEK-293T C212(1.35)  LDD1683  [3]
 LDCM0481  CL87 HEK-293T C212(1.06)  LDD1684  [3]
 LDCM0483  CL89 HEK-293T C212(1.17)  LDD1686  [3]
 LDCM0485  CL90 HEK-293T C212(1.34)  LDD1688  [3]
 LDCM0486  CL91 HEK-293T C212(1.11)  LDD1689  [3]
 LDCM0489  CL94 HEK-293T C212(1.04)  LDD1692  [3]
 LDCM0492  CL97 HEK-293T C212(1.04)  LDD1695  [3]
 LDCM0493  CL98 HEK-293T C212(1.07)  LDD1696  [3]
 LDCM0494  CL99 HEK-293T C212(1.07)  LDD1697  [3]
 LDCM0495  E2913 HEK-293T C212(1.07)  LDD1698  [3]
 LDCM0468  Fragment33 HEK-293T C212(1.00)  LDD1671  [3]
 LDCM0427  Fragment51 HEK-293T C212(1.02)  LDD1631  [3]
 LDCM0022  KB02 HEK-293T C212(0.83)  LDD1492  [3]
 LDCM0023  KB03 HEK-293T C212(0.95)  LDD1497  [3]
 LDCM0024  KB05 MEWO C212(2.57)  LDD3319  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein GLIS1 (GLIS1) GLI C2H2-type zinc-finger protein family Q8NBF1

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402