Details of the Target

General Information of Target

Target ID LDTP08627
Target Name YY1-associated factor 2 (YAF2)
Gene Name YAF2
Gene ID 10138
Synonyms
YY1-associated factor 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGDKKSPTRPKRQPKPSSDEGYWDCSVCTFRNSAEAFKCMMCDVRKGTSTRKPRPVSQLV
AQQVTQQFVPPTQSKKEKKDKVEKEKSEKETTSKKNSHKKTRPRLKNVDRSSAQHLEVTV
GDLTVIITDFKEKTKSPPASSAASADQHSQSGSSSDNTERGMSRSSSPRGEASSLNGESH
Target Bioclass
Other
Subcellular location
Nucleus
Function
Binds to MYC and inhibits MYC-mediated transactivation. Also binds to MYCN and enhances MYCN-dependent transcriptional activation. Increases calpain 2-mediated proteolysis of YY1 in vitro. Component of the E2F6.com-1 complex, a repressive complex that methylates 'Lys-9' of histone H3, suggesting that it is involved in chromatin-remodeling.
Uniprot ID
Q8IY57
Ensemble ID
ENST00000327791.8
HGNC ID
HGNC:17363

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CALU6 SNV: p.P7L .
HEC1 SNV: p.R110L .
HEC1B SNV: p.R110L .
NUGC3 SNV: p.S154N .
SW403 SNV: p.M162I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C-Sul
 Probe Info  		2.95  LDD0066  [1]
m-APA
 Probe Info  		N.A.  LDD2231  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA-directed RNA polymerase III subunit RPC7-like (POLR3GL) Eukaryotic RPC7 RNA polymerase subunit family Q9BT43
Serine/threonine-protein kinase MARK1 (MARK1) CAMK Ser/Thr protein kinase family Q9P0L2
Serine/threonine-protein kinase tousled-like 1 (TLK1) Ser/Thr protein kinase family Q9UKI8
E3 ubiquitin-protein ligase PPP1R11 (PPP1R11) . O60927
E3 ubiquitin-protein ligase RING1 (RING1) . Q06587
E3 ubiquitin-protein ligase RING2 (RNF2) . Q99496
SET-binding protein (SETBP1) . Q9Y6X0
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sperm protein associated with the nucleus on the X chromosome N2 (SPANXN2) SPAN-X family Q5MJ10
Other
Click To Hide/Show 14 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Acidic leucine-rich nuclear phosphoprotein 32 family member B (ANP32B) ANP32 family Q92688
Caveolae-associated protein 1 (CAVIN1) CAVIN family Q6NZI2
ELL-associated factor 1 (EAF1) EAF family Q96JC9
X antigen family member 1 (XAGE1A; XAGE1B) GAGE family Q9HD64
Progranulin (GRN) Granulin family P28799
Intraflagellar transport protein 57 homolog (IFT57) IFT57 family Q9NWB7
Microtubule-associated protein RP/EB family member 3 (MAPRE3) MAPRE family Q9UPY8
Dynein axonemal assembly factor 6 (DNAAF6) PIH1 family Q9NQM4
Sperm protein associated with the nucleus on the X chromosome N3 (SPANXN3) SPAN-X family Q5MJ09
Galectin-7 (LGALS7; LGALS7B) . P47929
INO80 complex subunit B (INO80B) . Q9C086
Nuclear transport factor 2 (NUTF2) . P61970
Protocadherin-17 (PCDH17) . O14917
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699

References

1 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
2 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377