Details of the Target

General Information of Target

Target ID LDTP08611
Target Name Electron transfer flavoprotein beta subunit lysine methyltransferase (ETFBKMT)
Gene Name ETFBKMT
Gene ID 254013
Synonyms
C12orf72; METTL20; Electron transfer flavoprotein beta subunit lysine methyltransferase; EC 2.1.1.-; ETFB lysine methyltransferase; ETFB-KMT; Protein N-lysine methyltransferase METTL20
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MALSLGWKAHRNHCGLLLQALRSSGLLLFPCGQCPWRGAGSFLDPEIKAFLEENTEVTSS
GSLTPEIQLRLLTPRCKFWWERADLWPHSDPYWAIYWPGGQALSRYLLDNPDVVRGKSVL
DLGSGCGATAIAAKMSGASRILANDIDPIAGMAITLNCELNRLNPFPILIQNILNLEQDK
WDLVVLGDMFYDEDLADSLHQWLKKCFWTYRTRVLIGDPGRPQFSGHSIQHHLHKVVEYS
LLESTRQENSGLTTSTVWGFQP
Target Bioclass
Enzyme
Family
Methyltransferase superfamily, ETFBKMT family
Subcellular location
Cytoplasm
Function
Protein-lysine methyltransferase that selectively trimethylates the flavoprotein ETFB in mitochondria. Thereby, may negatively regulate the function of ETFB in electron transfer from Acyl-CoA dehydrogenases to the main respiratory chain.
Uniprot ID
Q8IXQ9
Ensemble ID
ENST00000357721.3
HGNC ID
HGNC:28739

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C126(1.00)  LDD1512  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0259  AC14 HEK-293T C126(1.00)  LDD1512  [1]
 LDCM0282  AC22 HEK-293T C126(1.02)  LDD1521  [1]
 LDCM0291  AC30 HEK-293T C126(1.06)  LDD1530  [1]
 LDCM0299  AC38 HEK-293T C126(1.17)  LDD1538  [1]
 LDCM0308  AC46 HEK-293T C126(1.09)  LDD1547  [1]
 LDCM0317  AC54 HEK-293T C126(1.09)  LDD1556  [1]
 LDCM0323  AC6 HEK-293T C126(1.08)  LDD1562  [1]
 LDCM0326  AC62 HEK-293T C126(1.10)  LDD1565  [1]
 LDCM0368  CL10 HEK-293T C126(1.18)  LDD1572  [1]
 LDCM0410  CL22 HEK-293T C126(0.98)  LDD1614  [1]
 LDCM0423  CL34 HEK-293T C126(0.92)  LDD1627  [1]
 LDCM0436  CL46 HEK-293T C126(0.94)  LDD1640  [1]
 LDCM0449  CL58 HEK-293T C126(1.11)  LDD1652  [1]
 LDCM0463  CL70 HEK-293T C126(0.96)  LDD1666  [1]
 LDCM0476  CL82 HEK-293T C126(0.97)  LDD1679  [1]
 LDCM0489  CL94 HEK-293T C126(1.12)  LDD1692  [1]
 LDCM0022  KB02 BRX211 C206(1.40)  LDD2268  [2]
 LDCM0023  KB03 BRX211 C206(1.81)  LDD2685  [2]
 LDCM0024  KB05 BRX211 C206(2.02)  LDD3102  [2]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840