Details of the Target
General Information of Target
| Target ID | LDTP08579 | |||||
|---|---|---|---|---|---|---|
| Target Name | Protein KIBRA (WWC1) | |||||
| Gene Name | WWC1 | |||||
| Gene ID | 23286 | |||||
| Synonyms |
KIAA0869; Protein KIBRA; HBeAg-binding protein 3; Kidney and brain protein; KIBRA; WW domain-containing protein 1 |
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| 3D Structure | ||||||
| Sequence |
MPRPELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDELPLGWE
EAYDPQVGDYFIDHNTKTTQIEDPRVQWRREQEHMLKDYLVVAQEALSAQKEIYQVKQQR LELAQQEYQQLHAVWEHKLGSQVSLVSGSSSSSKYDPEILKAEIATAKSRVNKLKREMVH LQHELQFKERGFQTLKKIDKKMSDAQGSYKLDEAQAVLRETKAIKKAITCGEKEKQDLIK SLAMLKDGFRTDRGSHSDLWSSSSSLESSSFPLPKQYLDVSSQTDISGSFGINSNNQLAE KVRLRLRYEEAKRRIANLKIQLAKLDSEAWPGVLDSERDRLILINEKEELLKEMRFISPR KWTQGEVEQLEMARKRLEKDLQAARDTQSKALTERLKLNSKRNQLVRELEEATRQVATLH SQLKSLSSSMQSLSSGSSPGSLTSSRGSLVASSLDSSTSASFTDLYYDPFEQLDSELQSK VEFLLLEGATGFRPSGCITTIHEDEVAKTQKAEGGGRLQALRSLSGTPKSMTSLSPRSSL SSPSPPCSPLMADPLLAGDAFLNSLEFEDPELSATLCELSLGNSAQERYRLEEPGTEGKQ LGQAVNTAQGCGLKVACVSAAVSDESVAGDSGVYEASVQRLGASEAAAFDSDESEAVGAT RIQIALKYDEKNKQFAILIIQLSNLSALLQQQDQKVNIRVAVLPCSESTTCLFRTRPLDA SDTLVFNEVFWVSMSYPALHQKTLRVDVCTTDRSHLEECLGGAQISLAEVCRSGERSTRW YNLLSYKYLKKQSRELKPVGVMAPASGPASTDAVSALLEQTAVELEKRQEGRSSTQTLED SWRYEETSENEAVAEEEEEEVEEEEGEEDVFTEKASPDMDGYPALKVDKETNTETPAPSP TVVRPKDRRVGTPSQGPFLRGSTIIRSKTFSPGPQSQYVCRLNRSDSDSSTLSKKPPFVR NSLERRSVRMKRPSSVKSLRSERLIRTSLDLELDLQATRTWHSQLTQEISVLKELKEQLE QAKSHGEKELPQWLREDERFRLLLRMLEKRQMDRAEHKGELQTDKMMRAAAKDVHRLRGQ SCKEPPEVQSFREKMAFFTRPRMNIPALSADDV |
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| Target Bioclass |
Other
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| Family |
WWC family, KIBRA subfamily
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| Subcellular location |
Cytoplasm
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| Function |
Negative regulator of the Hippo signaling pathway, also known as the Salvador-Warts-Hippo (SWH) pathway. Enhances phosphorylation of LATS1 and YAP1 and negatively regulates cell proliferation and organ growth due to a suppression of the transcriptional activity of YAP1, the major effector of the Hippo pathway. Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and function in the regulation of Hippo signaling pathway. Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation. Regulates collagen-stimulated activation of the ERK/MAPK cascade. Modulates directional migration of podocytes. Plays a role in cognition and memory performance. Plays an important role in regulating AMPA-selective glutamate receptors (AMPARs) trafficking underlying synaptic plasticity and learning.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
STPyne Probe Info |
 |
K246(1.89); K319(10.00) | LDD0277 | [1] | |
|
DBIA Probe Info |
 |
C940(2.07) | LDD3346 | [2] | |
|
IA-alkyne Probe Info |
 |
N.A. | LDD0165 | [3] | |
|
NAIA_4 Probe Info |
 |
C497(0.00); C1082(0.00) | LDD2226 | [4] | |
|
IPM Probe Info |
 |
C1082(0.00); C940(0.00) | LDD0147 | [5] | |
|
Acrolein Probe Info |
 |
H420(0.00); K424(0.00) | LDD0217 | [6] | |
Competitor(s) Related to This Target
| Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
|---|---|---|---|---|---|
| LDCM0213 | Electrophilic fragment 2 | MDA-MB-231 | C611(1.35) | LDD1702 | [7] |
| LDCM0576 | Fragment14 | Ramos | C940(1.23) | LDD2193 | [8] |
| LDCM0580 | Fragment21 | Ramos | C940(1.26) | LDD2195 | [8] |
| LDCM0578 | Fragment27 | Ramos | C940(1.43) | LDD2197 | [8] |
| LDCM0586 | Fragment28 | Ramos | C940(0.98) | LDD2198 | [8] |
| LDCM0589 | Fragment31 | Ramos | C940(1.32) | LDD2200 | [8] |
| LDCM0468 | Fragment33 | Ramos | C940(0.83) | LDD2202 | [8] |
| LDCM0596 | Fragment38 | Ramos | C940(1.95) | LDD2203 | [8] |
| LDCM0610 | Fragment52 | Ramos | C940(2.73) | LDD2204 | [8] |
| LDCM0614 | Fragment56 | Ramos | C940(1.09) | LDD2205 | [8] |
| LDCM0022 | KB02 | 786-O | C230(2.91); C611(2.62); C940(3.74) | LDD2247 | [2] |
| LDCM0023 | KB03 | 786-O | C230(2.09); C611(3.57); C940(4.67) | LDD2664 | [2] |
| LDCM0024 | KB05 | NCI-H1666 | C940(2.07) | LDD3346 | [2] |
References