Details of the Target

General Information of Target

Target ID LDTP08440
Target Name ATP-binding cassette sub-family A member 9 (ABCA9)
Gene Name ABCA9
Gene ID 10350
Synonyms
ATP-binding cassette sub-family A member 9; EC 7.6.2.-
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSKRRMSVGQQTWALLCKNCLKKWRMKRQTLLEWLFSFLLVLFLYLFFSNLHQVHDTPQM
SSMDLGRVDSFNDTNYVIAFAPESKTTQEIMNKVASAPFLKGRTIMGWPDEKSMDELDLN
YSIDAVRVIFTDTFSYHLKFSWGHRIPMMKEHRDHSAHCQAVNEKMKCEGSEFWEKGFVA
FQAAINAAIIEIATNHSVMEQLMSVTGVHMKILPFVAQGGVATDFFIFFCIISFSTFIYY
VSVNVTQERQYITSLMTMMGLRESAFWLSWGLMYAGFILIMATLMALIVKSAQIVVLTGF
VMVFTLFLLYGLSLITLAFLMSVLIKKPFLTGLVVFLLIVFWGILGFPALYTRLPAFLEW
TLCLLSPFAFTVGMAQLIHLDYDVNSNAHLDSSQNPYLIIATLFMLVFDTLLYLVLTLYF
DKILPAEYGHRCSPLFFLKSCFWFQHGRANHVVLENETDSDPTPNDCFEPVSPEFCGKEA
IRIKNLKKEYAGKCERVEALKGVVFDIYEGQITALLGHSGAGKTTLLNILSGLSVPTSGS
VTVYNHTLSRMADIENISKFTGFCPQSNVQFGFLTVKENLRLFAKIKGILPHEVEKEVQR
VVQELEMENIQDILAQNLSGGQNRKLTFGIAILGDPQVLLLDEPTAGLDPLSRHRIWNLL
KEGKSDRVILFSTQFIDEADILADRKVFISNGKLKCAGSSLFLKKKWGIGYHLSLHLNER
CDPESITSLVKQHISDAKLTAQSEEKLVYILPLERTNKFPELYRDLDRCSNQGIEDYGVS
ITTLNEVFLKLEGKSTIDESDIGIWGQLQTDGAKDIGSLVELEQVLSSFHETRKTISGVA
LWRQQVCAIAKVRFLKLKKERKSLWTILLLFGISFIPQLLEHLFYESYQKSYPWELSPNT
YFLSPGQQPQDPLTHLLVINKTGSTIDNFLHSLRRQNIAIEVDAFGTRNGTDDPSYNGAI
IVSGDEKDHRFSIACNTKRLNCFPVLLDVISNGLLGIFNSSEHIQTDRSTFFEEHMDYEY
GYRSNTFFWIPMAASFTPYIAMSSIGDYKKKAHSQLRISGLYPSAYWFGQALVDVSLYFL
ILLLMQIMDYIFSPEEIIFIIQNLLIQILCSIGYVSSLVFLTYVISFIFRNGRKNSGIWS
FFFLIVVIFSIVATDLNEYGFLGLFFGTMLIPPFTLIGSLFIFSEISPDSMDYLGASESE
IVYLALLIPYLHFLIFLFILRCLEMNCRKKLMRKDPVFRISPRSNAIFPNPEEPEGEEED
IQMERMRTVNAMAVRDFDETPVIIASCLRKEYAGKKKNCFSKRKKKIATRNVSFCVKKGE
VIGLLGHNGAGKSTTIKMITGDTKPTAGQVILKGSGGGEPLGFLGYCPQENALWPNLTVR
QHLEVYAAVKGLRKGDAMIAITRLVDALKLQDQLKAPVKTLSEGIKRKLCFVLSILGNPS
VVLLDEPSTGMDPEGQQQMWQVIRATFRNTERGALLTTHYMAEAEAVCDRVAIMVSGRLR
CIGSIQHLKSKFGKDYLLEMKLKNLAQMEPLHAEILRLFPQAAQQERFSSLMVYKLPVED
VRPLSQAFFKLEIVKQSFDLEEYSLSQSTLEQVFLELSKEQELGDLEEDFDPSVKWKLLL
QEEP
Target Bioclass
Enzyme
Family
ABC transporter superfamily, ABCA family
Subcellular location
Membrane
Function Transporter that may play a role in monocyte differentiation and lipid transport and homeostasis.
Uniprot ID
Q8IUA7
Ensemble ID
ENST00000340001.9
HGNC ID
HGNC:39

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA Deletion: p.F1166LfsTer5 .
CAL148 SNV: p.E509K .
CCK81 SNV: p.A79V; p.A356V .
GB1 SNV: p.V839A .
HEC1 Insertion: p.S1184FfsTer2
SNV: p.W1067Ter		 .
HKGZCC SNV: p.Y397F .
HSC3 SNV: p.S1549C .
HT SNV: p.V602I; p.G1163W; p.K1296R .
HT115 SNV: p.E1224K .
Ishikawa (Heraklio) 02 ER Deletion: p.F1166LfsTer5
SNV: p.V41A;p.M199I		 .
KYSE180 SNV: p.A157S .
LN18 Deletion: p.N1135IfsTer10 .
MDAMB453 SNV: p.D1260H .
MEWO SNV: p.P984S .
NCIH196 SNV: p.E799D .
NCIH2286 SNV: p.G812V .
NCIH23 SNV: p.Q10Ter .
OV90 SNV: p.P1447L .
OVK18 SNV: p.K1426N .
SF295 SNV: p.W443C .
SW1271 SNV: p.Y382S .
SW1573 SNV: p.A265V .
SW756 SNV: p.S1059Ter .
TE10 SNV: p.D1235H; p.R1472T .
TE4 Deletion: p.K327NfsTer58 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TPP-AC
 Probe Info  		N.A.  LDD0427  [1]

References

1 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.