Details of the Target

General Information of Target

Target ID LDTP08408
Target Name Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PPARGC1B)
Gene Name PPARGC1B
Gene ID 133522
Synonyms
PERC; PGC1; PGC1B; PPARGC1; Peroxisome proliferator-activated receptor gamma coactivator 1-beta; PGC-1-beta; PPAR-gamma coactivator 1-beta; PPARGC-1-beta; PGC-1-related estrogen receptor alpha coactivator
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGNDCGALLDEELSSFFLNYLADTQGGGSGEEQLYADFPELDLSQLDASDFDSATCFGE
LQWCPENSETEPNQYSPDDSELFQIDSENEALLAELTKTLDDIPEDDVGLAAFPALDGGD
ALSCTSASPAPSSAPPSPAPEKPSAPAPEVDELSLLQKLLLATSYPTSSSDTQKEGTAWR
QAGLRSKSQRPCVKADSTQDKKAPMMQSQSRSCTELHKHLTSAQCCLQDRGLQPPCLQSP
RLPAKEDKEPGEDCPSPQPAPASPRDSLALGRADPGAPVSQEDMQAMVQLIRYMHTYCLP
QRKLPPQTPEPLPKACSNPSQQVRSRPWSRHHSKASWAEFSILRELLAQDVLCDVSKPYR
LATPVYASLTPRSRPRPPKDSQASPGRPSSVEEVRIAASPKSTGPRPSLRPLRLEVKREV
RRPARLQQQEEEDEEEEEEEEEEEKEEEEEWGRKRPGRGLPWTKLGRKLESSVCPVRRSR
RLNPELGPWLTFADEPLVPSEPQGALPSLCLAPKAYDVERELGSPTDEDSGQDQQLLRGP
QIPALESPCESGCGDMDEDPSCPQLPPRDSPRCLMLALSQSDPTFGKKSFEQTLTVELCG
TAGLTPPTTPPYKPTEEDPFKPDIKHSLGKEIALSLPSPEGLSLKATPGAAHKLPKKHPE
RSELLSHLRHATAQPASQAGQKRPFSCSFGDHDYCQVLRPEGVLQRKVLRSWEPSGVHLE
DWPQQGAPWAEAQAPGREEDRSCDAGAPPKDSTLLRDHEIRASLTKHFGLLETALEEEDL
ASCKSPEYDTVFEDSSSSSGESSFLPEEEEEEGEEEEEDDEEEDSGVSPTCSDHCPYQSP
PSKANRQLCSRSRSSSGSSPCHSWSPATRRNFRCESRGPCSDRTPSIRHARKRREKAIGE
GRVVYIQNLSSDMSSRELKRRFEVFGEIEECEVLTRNRRGEKYGFITYRCSEHAALSLTK
GAALRKRNEPSFQLSYGGLRHFCWPRYTDYDSNSEEALPASGKSKYEAMDFDSLLKEAQQ
SLH
Target Type
Literature-reported
Target Bioclass
Other
Subcellular location
Nucleus
Function
Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner.
TTD ID
T98395
Uniprot ID
Q86YN6
DrugMap ID
TTKSQ3W
Ensemble ID
ENST00000309241.10
HGNC ID
HGNC:30022

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A375 SNV: p.P313S .
AN3CA SNV: p.P648Q .
COLO678 SNV: p.E415G .
HT3 SNV: p.L268V .
IPC298 SNV: p.P637L .
MCC13 SNV: p.L237F .
MELHO SNV: p.L642V .
NB1 SNV: p.R980Q .
NCIH2286 SNV: p.Y297N .
NCIH23 SNV: p.G629V .
NCIH82 SNV: p.I887V .
NUGC3 SNV: p.A577V .
RKO Deletion: p.S137AfsTer69 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C316(0.99)  LDD1511  [1]
CY4
 Probe Info  		M205(0.00); M206(0.00)  LDD0247  [2]
IPM
 Probe Info  		C316(0.00); C474(0.00); C213(0.00)  LDD2156  [3]
Acrolein
 Probe Info  		N.A.  LDD0217  [4]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [4]
Methacrolein
 Probe Info  		N.A.  LDD0218  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0281  AC21 HEK-293T C316(0.97)  LDD1520  [1]
 LDCM0289  AC29 HEK-293T C316(1.09)  LDD1528  [1]
 LDCM0298  AC37 HEK-293T C316(1.01)  LDD1537  [1]
 LDCM0307  AC45 HEK-293T C316(1.01)  LDD1546  [1]
 LDCM0312  AC5 HEK-293T C316(0.99)  LDD1551  [1]
 LDCM0316  AC53 HEK-293T C316(0.93)  LDD1555  [1]
 LDCM0325  AC61 HEK-293T C316(0.99)  LDD1564  [1]
 LDCM0248  AKOS034007472 HEK-293T C316(0.99)  LDD1511  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [4]
 LDCM0372  CL103 HEK-293T C316(1.00)  LDD1576  [1]
 LDCM0376  CL107 HEK-293T C316(1.00)  LDD1580  [1]
 LDCM0381  CL111 HEK-293T C316(1.04)  LDD1585  [1]
 LDCM0385  CL115 HEK-293T C316(1.10)  LDD1589  [1]
 LDCM0389  CL119 HEK-293T C316(1.06)  LDD1593  [1]
 LDCM0394  CL123 HEK-293T C316(0.95)  LDD1598  [1]
 LDCM0398  CL127 HEK-293T C316(0.97)  LDD1602  [1]
 LDCM0402  CL15 HEK-293T C316(0.90)  LDD1606  [1]
 LDCM0409  CL21 HEK-293T C316(1.08)  LDD1613  [1]
 LDCM0415  CL27 HEK-293T C316(0.92)  LDD1619  [1]
 LDCM0418  CL3 HEK-293T C316(0.95)  LDD1622  [1]
 LDCM0422  CL33 HEK-293T C316(0.97)  LDD1626  [1]
 LDCM0428  CL39 HEK-293T C316(0.97)  LDD1632  [1]
 LDCM0435  CL45 HEK-293T C316(1.13)  LDD1639  [1]
 LDCM0448  CL57 HEK-293T C316(1.13)  LDD1651  [1]
 LDCM0455  CL63 HEK-293T C316(0.95)  LDD1658  [1]
 LDCM0461  CL69 HEK-293T C316(1.08)  LDD1664  [1]
 LDCM0475  CL81 HEK-293T C316(1.08)  LDD1678  [1]
 LDCM0481  CL87 HEK-293T C316(0.90)  LDD1684  [1]
 LDCM0484  CL9 HEK-293T C316(1.05)  LDD1687  [1]
 LDCM0488  CL93 HEK-293T C316(1.00)  LDD1691  [1]
 LDCM0494  CL99 HEK-293T C316(1.02)  LDD1697  [1]
 LDCM0495  E2913 HEK-293T C316(1.06)  LDD1698  [1]
 LDCM0468  Fragment33 HEK-293T C316(0.93)  LDD1671  [1]
 LDCM0107  IAA HeLa N.A.  LDD0221  [4]
 LDCM0109  NEM HeLa N.A.  LDD0223  [4]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Amiodarone Small molecular drug DB01118

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.