Details of the Target
General Information of Target
| Target ID | LDTP08384 | |||||
|---|---|---|---|---|---|---|
| Target Name | Xylosyltransferase 1 (XYLT1) | |||||
| Gene Name | XYLT1 | |||||
| Gene ID | 64131 | |||||
| Synonyms |
XT1; Xylosyltransferase 1; EC 2.4.2.26; Peptide O-xylosyltransferase 1; Xylosyltransferase I; XT-I; XylT-I |
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| 3D Structure | ||||||
| Sequence |
MVAAPCARRLARRSHSALLAALTVLLLQTLVVWNFSSLDSGAGERRGGAAVGGGEQPPPA
PAPRRERRDLPAEPAAARGGGGGGGGGGGGRGPQARARGGGPGEPRGQQPASRGALPARA LDPHPSPLITLETQDGYFSHRPKEKVRTDSNNENSVPKDFENVDNSNFAPRTQKQKHQPE LAKKPPSRQKELLKRKLEQQEKGKGHTFPGKGPGEVLPPGDRAAANSSHGKDVSRPPHAR KTGGSSPETKYDQPPKCDISGKEAISALSRAKSKHCRQEIGETYCRHKLGLLMPEKVTRF CPLEGKANKNVQWDEDSVEYMPANPVRIAFVLVVHGRASRQLQRMFKAIYHKDHFYYIHV DKRSNYLHRQVLQVSRQYSNVRVTPWRMATIWGGASLLSTYLQSMRDLLEMTDWPWDFFI NLSAADYPIRTNDQLVAFLSRYRDMNFLKSHGRDNARFIRKQGLDRLFLECDAHMWRLGD RRIPEGIAVDGGSDWFLLNRRFVEYVTFSTDDLVTKMKQFYSYTLLPAESFFHTVLENSP HCDTMVDNNLRITNWNRKLGCKCQYKHIVDWCGCSPNDFKPQDFHRFQQTARPTFFARKF EAVVNQEIIGQLDYYLYGNYPAGTPGLRSYWENVYDEPDGIHSLSDVTLTLYHSFARLGL RRAETSLHTDGENSCRYYPMGHPASVHLYFLADRFQGFLIKHHATNLAVSKLETLETWVM PKKVFKIASPPSDFGRLQFSEVGTDWDAKERLFRNFGGLLGPMDEPVGMQKWGKGPNVTV TVIWVDPVNVIAATYDILIESTAEFTHYKPPLNLPLRPGVWTVKILHHWVPVAETKFLVA PLTFSNRQPIKPEEALKLHNGPLRNAYMEQSFQSLNPVLSLPINPAQVEQARRNAASTGT ALEGWLDSLVGGMWTAMDICATGPTACPVMQTCSQTAWSSFSPDPKSELGAVKPDGRLR |
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| Target Bioclass |
Enzyme
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| Family |
Glycosyltransferase 14 family, XylT subfamily
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| Subcellular location |
Golgi apparatus membrane
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| Function |
Catalyzes the first step in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans, such as DCN. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. Required for normal embryonic and postnatal skeleton development, especially of the long bones. Required for normal maturation of chondrocytes during bone development, and normal onset of ossification.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
IA-alkyne Probe Info |
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C6(0.71) | LDD2190 | [1] | |
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HHS-465 Probe Info |
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N.A. | LDD2240 | [2] | |
Competitor(s) Related to This Target
| Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
|---|---|---|---|---|---|
| LDCM0573 | Fragment11 | Ramos | C6(0.71) | LDD2190 | [1] |
| LDCM0580 | Fragment21 | Ramos | C6(0.95) | LDD2195 | [1] |
| LDCM0578 | Fragment27 | Ramos | C6(0.71) | LDD2197 | [1] |
| LDCM0586 | Fragment28 | Ramos | C6(1.02) | LDD2198 | [1] |
| LDCM0589 | Fragment31 | Ramos | C6(1.15) | LDD2200 | [1] |
| LDCM0468 | Fragment33 | Ramos | C6(1.90) | LDD2202 | [1] |
| LDCM0596 | Fragment38 | Ramos | C6(1.99) | LDD2203 | [1] |
References