Details of the Target

General Information of Target

Target ID LDTP08366
Target Name RNA-binding protein MEX3D (MEX3D)
Gene Name MEX3D
Gene ID 399664
Synonyms
KIAA2031; RKHD1; RNF193; RNA-binding protein MEX3D; RING finger and KH domain-containing protein 1; RING finger protein 193; TINO
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPSSLGQPDGGGGGGGGGGGVGAAGEDPGPGPAPPPEGAQEAAPAPRPPPEPDDAAAALR
LALDQLSALGLGGAGDTDEEGAAGDGAAAAGGADGGAAPEPVPPDGPEAGAPPTLAPAVA
PGSLPLLDPNASPPPPPPPRPSPPDVFAGFAPHPAALGPPTLLADQMSVIGSRKKSVNMT
ECVPVPSSEHVAEIVGRQGCKIKALRAKTNTYIKTPVRGEEPVFIVTGRKEDVEMAKREI
LSAAEHFSIIRATRSKAGGLPGAAQGPPNLPGQTTIQVRVPYRVVGLVVGPKGATIKRIQ
QRTHTYIVTPGRDKEPVFAVTGMPENVDRAREEIEAHITLRTGAFTDAGPDSDFHANGTD
VCLDLLGAAASLWAKTPNQGRRPPTATAGLRGDTALGAPSAPEAFYAGSRGGPSVPDPGP
ASPYSGSGNGGFAFGAEGPGAPVGTAAPDDCDFGFDFDFLALDLTVPAAATIWAPFERAA
PLPAFSGCSTVNGAPGPPAAGARRSSGAGTPRHSPTLPEPGGLRLELPLSRRGAPDPVGA
LSWRPPQGPVSFPGGAAFSTATSLPSSPAAAACAPLDSGASENSRKPPSASSAPALAREC
VVCAEGEVMAALVPCGHNLFCMDCAVRICGKSEPECPACRTPATQAIHIFS
Target Bioclass
Other
Subcellular location
Cytoplasm
Function RNA binding protein, may be involved in post-transcriptional regulatory mechanisms.
Uniprot ID
Q86XN8
Ensemble ID
ENST00000402693.5
HGNC ID
HGNC:16734

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.R279C .
AN3CA SNV: p.K237M .
CCK81 SNV: p.D347G .
HCC1954 Substitution: p.L390F .
HCT116 SNV: p.G272E; p.L464M .
KYSE180 Substitution: p.P614F .
MCC26 SNV: p.R391C .
MFE319 SNV: p.R640C .
MOLT4 SNV: p.R312S .
PC9 SNV: p.A55S .
RKO SNV: p.L390F .
SKNSH SNV: p.D536Y .
SW1116 SNV: p.A370P .
YSCCC SNV: p.E403D .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C182(3.12)  LDD0168  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [2]
NAIA_4
 Probe Info  		C362(0.00); C488(0.00)  LDD2226  [3]
TFBX
 Probe Info  		N.A.  LDD0027  [4]
IPM
 Probe Info  		N.A.  LDD0147  [4]
AOyne
 Probe Info  		12.40  LDD0443  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C182(3.12)  LDD0168  [1]
 LDCM0026  4SU-RNA+native RNA HEK-293T C182(3.41)  LDD0169  [1]

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.