Details of the Target

General Information of Target

Target ID LDTP08357
Target Name Dihydrofolate reductase 2, mitochondrial (DHFR2)
Gene Name DHFR2
Gene ID 200895
Synonyms
DHFRL1; DHFRP4; Dihydrofolate reductase 2, mitochondrial; Dihydrofolate reductase, mitochondrial; EC 1.5.1.3; Dihydrofolate reductase-like protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFLLLNCIVAVSQNMGIGKNGDLPRPPLRNEFRYFQRMTTTSSVEGKQNLVIMGRKTWFS
IPEKNRPLKDRINLVLSRELKEPPQGAHFLARSLDDALKLTERPELANKVDMIWIVGGSS
VYKEAMNHLGHLKLFVTRIMQDFESDTFFSEIDLEKYKLLPEYPGVLSDVQEGKHIKYKF
EVCEKDD
Target Bioclass
Enzyme
Family
Dihydrofolate reductase family
Subcellular location
Mitochondrion
Function Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Binds its own mRNA and that of DHFR.
Uniprot ID
Q86XF0
Ensemble ID
ENST00000314636.3
HGNC ID
HGNC:27309

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
PF-06672131
 Probe Info  		N.A.  LDD0152  [1]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 9 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
5-(4-methoxyphenoxy)-24-quinazolinediamine Small molecular drug DB02402
5-chloryl-246-quinazolinetriamine Small molecular drug DB01929
5-phenylsulfanyl-24-quinazolinediamine Small molecular drug DB04163
5-[(4-methylphenyl)Sulfanyl]-24-quinazolinediamine Small molecular drug DB04306
Epigallocatechin Gallate Small molecular drug DB12116
5-(4-morpholin-4-yl-phenylsulfanyl)-24-quinazolinediamine . DB02001
5-[4-tert-butylphenylsulfanyl]-24-quinazolinediamine . DB01958
7-(1-ethyl-propyl)-7h-pyrrolo-[32-f]Quinazoline-13-diamine . DB07862
7-[2-methoxy-1-(Methoxymethyl)Ethyl]-7h-pyrrolo[32-f] Quinazoline-13-diamine . DB08203

References

1 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569