Details of the Target

General Information of Target

Target ID LDTP08318
Target Name Spermatogenesis-associated protein 24 (SPATA24)
Gene Name SPATA24
Gene ID 202051
Synonyms
Spermatogenesis-associated protein 24; Testis protein T6441 homolog
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATPLGWSKAGSGSVCLALDQLRDVIESQEELIHQLRNVMVLQDENFVSKEEFQAVEKKL
VEEKAAHAKTKVLLAKEEEKLQFALGEVEVLSKQLEKEKLAFEKALSSVKSKVLQESSKK
DQLITKCNEIESHIIKQEDILNGKENEIKELQQVISQQKQIFRNHMSDFRIQKQQESYMA
QVLDQKHKKASGTRQARSHQHPREK
Target Bioclass
Other
Family
SPATA24 family
Subcellular location
Cytoplasm
Function
Binds DNA with high affinity but does not bind to TATA boxes. Synergises with GMNN and TBP in activation of TATA box-containing promoters and with GMNN and TBPL1 in activation of the NF1 TATA-less promoter. May play a role in cytoplasm movement and removal during spermiogenesis.
Uniprot ID
Q86W54
Ensemble ID
ENST00000450845.7
HGNC ID
HGNC:27322

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.Q152R .
HCT15 SNV: p.H67R .
OVKATE SNV: p.K104E .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C127(1.04)  LDD1507  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C127(1.04)  LDD1507  [1]
 LDCM0270  AC15 HEK-293T C127(0.99)  LDD1513  [1]
 LDCM0276  AC17 HEK-293T C127(1.24)  LDD1515  [1]
 LDCM0281  AC21 HEK-293T C127(1.12)  LDD1520  [1]
 LDCM0283  AC23 HEK-293T C127(1.03)  LDD1522  [1]
 LDCM0285  AC25 HEK-293T C127(1.27)  LDD1524  [1]
 LDCM0289  AC29 HEK-293T C127(1.20)  LDD1528  [1]
 LDCM0292  AC31 HEK-293T C127(1.15)  LDD1531  [1]
 LDCM0294  AC33 HEK-293T C127(1.08)  LDD1533  [1]
 LDCM0298  AC37 HEK-293T C127(0.95)  LDD1537  [1]
 LDCM0300  AC39 HEK-293T C127(1.09)  LDD1539  [1]
 LDCM0303  AC41 HEK-293T C127(1.29)  LDD1542  [1]
 LDCM0307  AC45 HEK-293T C127(1.22)  LDD1546  [1]
 LDCM0309  AC47 HEK-293T C127(0.91)  LDD1548  [1]
 LDCM0311  AC49 HEK-293T C127(1.25)  LDD1550  [1]
 LDCM0312  AC5 HEK-293T C127(0.96)  LDD1551  [1]
 LDCM0316  AC53 HEK-293T C127(1.21)  LDD1555  [1]
 LDCM0318  AC55 HEK-293T C127(1.27)  LDD1557  [1]
 LDCM0320  AC57 HEK-293T C127(1.06)  LDD1559  [1]
 LDCM0325  AC61 HEK-293T C127(1.24)  LDD1564  [1]
 LDCM0327  AC63 HEK-293T C127(1.06)  LDD1566  [1]
 LDCM0334  AC7 HEK-293T C127(1.07)  LDD1568  [1]
 LDCM0248  AKOS034007472 HEK-293T C127(1.16)  LDD1511  [1]
 LDCM0356  AKOS034007680 HEK-293T C127(1.34)  LDD1570  [1]
 LDCM0379  CL11 HEK-293T C127(0.78)  LDD1583  [1]
 LDCM0404  CL17 HEK-293T C127(0.90)  LDD1608  [1]
 LDCM0409  CL21 HEK-293T C127(1.05)  LDD1613  [1]
 LDCM0411  CL23 HEK-293T C127(0.96)  LDD1615  [1]
 LDCM0417  CL29 HEK-293T C127(0.95)  LDD1621  [1]
 LDCM0422  CL33 HEK-293T C127(1.04)  LDD1626  [1]
 LDCM0424  CL35 HEK-293T C127(1.10)  LDD1628  [1]
 LDCM0431  CL41 HEK-293T C127(1.25)  LDD1635  [1]
 LDCM0435  CL45 HEK-293T C127(1.00)  LDD1639  [1]
 LDCM0437  CL47 HEK-293T C127(1.03)  LDD1641  [1]
 LDCM0440  CL5 HEK-293T C127(1.29)  LDD1644  [1]
 LDCM0444  CL53 HEK-293T C127(1.00)  LDD1647  [1]
 LDCM0448  CL57 HEK-293T C127(1.08)  LDD1651  [1]
 LDCM0450  CL59 HEK-293T C127(0.98)  LDD1653  [1]
 LDCM0457  CL65 HEK-293T C127(1.50)  LDD1660  [1]
 LDCM0461  CL69 HEK-293T C127(1.01)  LDD1664  [1]
 LDCM0464  CL71 HEK-293T C127(0.89)  LDD1667  [1]
 LDCM0470  CL77 HEK-293T C127(1.47)  LDD1673  [1]
 LDCM0475  CL81 HEK-293T C127(1.05)  LDD1678  [1]
 LDCM0477  CL83 HEK-293T C127(0.92)  LDD1680  [1]
 LDCM0483  CL89 HEK-293T C127(1.26)  LDD1686  [1]
 LDCM0484  CL9 HEK-293T C127(1.06)  LDD1687  [1]
 LDCM0488  CL93 HEK-293T C127(1.16)  LDD1691  [1]
 LDCM0490  CL95 HEK-293T C127(0.68)  LDD1693  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402